SG11B_MOUSE
ID SG11B_MOUSE Reviewed; 113 AA.
AC Q3UW43; Q2HPE2;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Sperm-associated antigen 11B {ECO:0000312|MGI:MGI:3647173};
DE AltName: Full=Protein EP2 {ECO:0000250|UniProtKB:Q08648};
DE Flags: Precursor;
GN Name=Spag11b {ECO:0000312|MGI:MGI:3647173};
GN Synonyms=Ep2 {ECO:0000250|UniProtKB:Q08648}, Ep2c/h {ECO:0000305},
GN Spag11c {ECO:0000303|PubMed:16033865};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:AAT57926.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=CD; TISSUE=Epididymis;
RA Yashwanth R., Yenugu S., Hamil K.G., French F.S., Hall S.H.;
RT "Identification of novel beta-defensin isoforms in mice.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAY59787.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT "Cross-species analysis of the mammalian beta-defensin gene family:
RT presence of syntenic gene clusters and preferential expression in the male
RT reproductive tract.";
RL Physiol. Genomics 23:5-17(2005).
RN [3] {ECO:0000312|EMBL:BAE23076.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE23076.1};
RC TISSUE=Epididymis {ECO:0000312|EMBL:BAE23076.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Has antimicrobial activity against E.coli (By similarity).
CC Plays a role in the defense response in the male reproductive tract,
CC contributing to sperm maturation, storage and protection (By
CC similarity). {ECO:0000250|UniProtKB:Q8VBV2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UW43-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UW43-2; Sequence=VSP_061386, VSP_061387, VSP_061388;
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY552531; AAT57926.1; -; mRNA.
DR EMBL; DQ012055; AAY59787.1; -; mRNA.
DR EMBL; AK136627; BAE23076.1; -; mRNA.
DR CCDS; CCDS22133.1; -. [Q3UW43-1]
DR CCDS; CCDS40251.1; -. [Q3UW43-2]
DR RefSeq; NP_001030077.1; NM_001034905.2.
DR RefSeq; NP_001034652.2; NM_001039563.3.
DR RefSeq; NP_001273422.1; NM_001286493.1.
DR STRING; 10090.ENSMUSP00000048125; -.
DR Ensembl; ENSMUST00000039075; ENSMUSP00000048125; ENSMUSG00000059463. [Q3UW43-1]
DR Ensembl; ENSMUST00000110767; ENSMUSP00000106395; ENSMUSG00000059463. [Q3UW43-2]
DR GeneID; 546038; -.
DR KEGG; mmu:546038; -.
DR UCSC; uc009laf.1; mouse. [Q3UW43-1]
DR CTD; 10407; -.
DR MGI; MGI:3647173; Spag11b.
DR VEuPathDB; HostDB:ENSMUSG00000059463; -.
DR GeneTree; ENSGT00940000161432; -.
DR HOGENOM; CLU_178650_0_0_1; -.
DR OrthoDB; 1572254at2759; -.
DR PhylomeDB; Q3UW43; -.
DR BioGRID-ORCS; 546038; 3 hits in 72 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000059463; Expressed in esophagus and 10 other tissues.
DR ExpressionAtlas; Q3UW43; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0051838; P:cytolysis by host of symbiont cells; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR InterPro; IPR007988; Sperm_Ag_11A_B.
DR PANTHER; PTHR14081; PTHR14081; 1.
DR Pfam; PF00711; Defensin_beta; 1.
DR Pfam; PF05324; Sperm_Ag_HE2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..113
FT /note="Sperm-associated antigen 11B"
FT /evidence="ECO:0000255"
FT /id="PRO_5015097509"
FT DISULFID 80..108
FT /evidence="ECO:0000250|UniProtKB:Q91V82"
FT DISULFID 87..101
FT /evidence="ECO:0000250|UniProtKB:Q91V82"
FT DISULFID 91..109
FT /evidence="ECO:0000250|UniProtKB:Q91V82"
FT VAR_SEQ 20
FT /note="P -> PA (in isoform 2)"
FT /id="VSP_061386"
FT VAR_SEQ 70..89
FT /note="EPEPNYQIVNCKKSEGQCQE -> GKSSTQDQGKFIHLGNTERM (in
FT isoform 2)"
FT /id="VSP_061387"
FT VAR_SEQ 90..113
FT /note="Missing (in isoform 2)"
FT /id="VSP_061388"
FT CONFLICT 10
FT /note="A -> V (in Ref. 1; AAT57926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 12857 MW; D22D50592780122B CRC64;
MIPRLLPFFA SLLFAALLFP GLSNASSINH LVTEPPSFPK DEFPARGVNG SQLLHHRVKR
LPPRTPPYHE PEPNYQIVNC KKSEGQCQEY CNFMETQVGY CSKKKEPCCL HPF
