ID   SG1C1_HUMAN             Reviewed;          95 AA.
AC   Q8TD33; A8MSI9; Q14DW0;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Secretoglobin family 1C member 1;
DE   AltName: Full=Secretoglobin RYD5;
DE   Flags: Precursor;
GN   Name=SCGB1C1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-70.
RA   Bingle C.D.;
RT   "Human RYD5, a new secretoglobin.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-70.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION, AND VARIANT ARG-70.
RX   PubMed=12406855; DOI=10.1164/rccm.200204-285oc;
RA   Reynolds S.D., Reynolds P.R., Pryhuber G.S., Finder J.D., Stripp B.R.;
RT   "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse
RT   and human airways.";
RL   Am. J. Respir. Crit. Care Med. 166:1498-1509(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR   EMBL; AY026938; AAK08972.1; -; mRNA.
DR   EMBL; AC069287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069287; AAH69287.1; -; mRNA.
DR   EMBL; BC111427; AAI11428.1; -; mRNA.
DR   EMBL; BC111433; AAI11434.1; -; mRNA.
DR   EMBL; BK000201; DAA00358.1; -; mRNA.
DR   CCDS; CCDS41581.1; -.
DR   RefSeq; NP_001091079.1; NM_001097610.2.
DR   RefSeq; NP_663626.2; NM_145651.2.
DR   AlphaFoldDB; Q8TD33; -.
DR   SMR; Q8TD33; -.
DR   BioGRID; 127046; 26.
DR   BioGRID; 575819; 1.
DR   IntAct; Q8TD33; 1.
DR   STRING; 9606.ENSP00000344545; -.
DR   iPTMnet; Q8TD33; -.
DR   PhosphoSitePlus; Q8TD33; -.
DR   BioMuta; SCGB1C1; -.
DR   DMDM; 296452904; -.
DR   MassIVE; Q8TD33; -.
DR   PaxDb; Q8TD33; -.
DR   PeptideAtlas; Q8TD33; -.
DR   PRIDE; Q8TD33; -.
DR   Antibodypedia; 76942; 24 antibodies from 5 providers.
DR   DNASU; 147199; -.
DR   Ensembl; ENST00000342878.3; ENSP00000344545.2; ENSG00000188076.3.
DR   GeneID; 147199; -.
DR   GeneID; 653486; -.
DR   KEGG; hsa:147199; -.
DR   KEGG; hsa:653486; -.
DR   MANE-Select; ENST00000342878.3; ENSP00000344545.2; NM_145651.3; NP_663626.2.
DR   UCSC; uc001loa.1; human.
DR   CTD; 147199; -.
DR   CTD; 653486; -.
DR   DisGeNET; 147199; -.
DR   DisGeNET; 653486; -.
DR   GeneCards; SCGB1C1; -.
DR   HGNC; HGNC:18394; SCGB1C1.
DR   HPA; ENSG00000188076; Tissue enhanced (brain, pancreas, retina, salivary gland).
DR   MIM; 610176; gene.
DR   neXtProt; NX_Q8TD33; -.
DR   OpenTargets; ENSG00000188076; -.
DR   VEuPathDB; HostDB:ENSG00000188076; -.
DR   eggNOG; ENOG502SDMQ; Eukaryota.
DR   GeneTree; ENSGT00940000155073; -.
DR   HOGENOM; CLU_184622_0_0_1; -.
DR   InParanoid; Q8TD33; -.
DR   OMA; DNNEFFM; -.
DR   OrthoDB; 1523777at2759; -.
DR   PhylomeDB; Q8TD33; -.
DR   TreeFam; TF337061; -.
DR   PathwayCommons; Q8TD33; -.
DR   SignaLink; Q8TD33; -.
DR   BioGRID-ORCS; 147199; 182 hits in 660 CRISPR screens.
DR   BioGRID-ORCS; 653486; 10 hits in 155 CRISPR screens.
DR   Pharos; Q8TD33; Tdark.
DR   PRO; PR:Q8TD33; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8TD33; protein.
DR   Bgee; ENSG00000188076; Expressed in monocyte and 75 other tissues.
DR   Genevisible; Q8TD33; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR043215; Secretoglobin_1C-like.
DR   InterPro; IPR028659; Secretoglobin_1C1/2.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   PANTHER; PTHR10136; PTHR10136; 1.
DR   PANTHER; PTHR10136:SF8; PTHR10136:SF8; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..95
FT                   /note="Secretoglobin family 1C member 1"
FT                   /id="PRO_0000223332"
FT   VARIANT         70
FT                   /note="I -> R (in dbSNP:rs2686894)"
FT                   /evidence="ECO:0000269|PubMed:12406855,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_063102"
SQ   SEQUENCE   95 AA;  10414 MW;  F6331EADC96D2392 CRC64;
     MKGSRALLLV ALTLFCICRM ATGEDNDEFF MDFLQTLLVG TPEELYEGTL GKYNVNEDAK
     AAMTELKSCI DGLQPMHKAE LVKLLVQVLG SQDGA