SG1D1_HUMAN
ID SG1D1_HUMAN Reviewed; 90 AA.
AC O95968;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Secretoglobin family 1D member 1;
DE AltName: Full=Lipophilin-A;
DE Flags: Precursor;
GN Name=SCGB1D1; Synonyms=LIPHA, LPNA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10066439; DOI=10.1006/bbrc.1999.0274;
RA Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.;
RT "Lipophilins: human peptides homologous to rat prostatein.";
RL Biochem. Biophys. Res. Commun. 256:147-155(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 22-90, AND MASS SPECTROMETRY.
RX PubMed=9720917; DOI=10.1016/s0014-5793(98)00852-7;
RA Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D.,
RA Glasgow B.J.;
RT "Lipophilin, a novel heterodimeric protein of human tears.";
RL FEBS Lett. 432:163-167(1998).
RN [4]
RP PROTEIN SEQUENCE OF 22-90, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Tear;
RX PubMed=25946035; DOI=10.1021/acs.jproteome.5b00179;
RA Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I.,
RA Suarez T., Elortza F.;
RT "Human basal tear peptidome characterization by CID, HCD, and ETD followed
RT by in silico and in vitro analyses for antimicrobial peptide
RT identification.";
RL J. Proteome Res. 14:2649-2658(2015).
CC -!- FUNCTION: May bind androgens and other steroids, may also bind
CC estramustine, a chemotherapeutic agent used for prostate cancer. May be
CC under transcriptional regulation of steroid hormones.
CC -!- SUBUNIT: Heterodimer of a lipophilin A and a lipophilin C (mammaglobin
CC B) monomer associated head to head.
CC -!- INTERACTION:
CC O95968; Q9H9P2: CHODL; NbExp=3; IntAct=EBI-12825395, EBI-17447707;
CC O95968; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12825395, EBI-6942903;
CC O95968; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12825395, EBI-18304435;
CC O95968; O15552: FFAR2; NbExp=3; IntAct=EBI-12825395, EBI-2833872;
CC O95968; P35372-10: OPRM1; NbExp=3; IntAct=EBI-12825395, EBI-12807478;
CC O95968; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-12825395, EBI-9978441;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in lachrymal gland, thymus, kidney,
CC testis, ovary and salivary gland.
CC -!- MASS SPECTROMETRY: Mass=7574.69; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:9720917};
CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ224171; CAA11863.1; -; mRNA.
DR EMBL; BC069170; AAH69170.1; -; mRNA.
DR EMBL; BC062693; AAH62693.1; -; mRNA.
DR EMBL; BC069289; AAH69289.1; -; mRNA.
DR CCDS; CCDS8015.1; -.
DR RefSeq; NP_006543.1; NM_006552.1.
DR AlphaFoldDB; O95968; -.
DR SMR; O95968; -.
DR BioGRID; 115892; 147.
DR IntAct; O95968; 78.
DR STRING; 9606.ENSP00000303070; -.
DR iPTMnet; O95968; -.
DR PhosphoSitePlus; O95968; -.
DR BioMuta; SCGB1D1; -.
DR MassIVE; O95968; -.
DR PaxDb; O95968; -.
DR PeptideAtlas; O95968; -.
DR PRIDE; O95968; -.
DR ProteomicsDB; 51149; -.
DR DNASU; 10648; -.
DR Ensembl; ENST00000306238.3; ENSP00000303070.3; ENSG00000168515.3.
DR GeneID; 10648; -.
DR KEGG; hsa:10648; -.
DR MANE-Select; ENST00000306238.3; ENSP00000303070.3; NM_006552.2; NP_006543.1.
DR UCSC; uc001nsz.2; human.
DR CTD; 10648; -.
DR DisGeNET; 10648; -.
DR GeneCards; SCGB1D1; -.
DR HGNC; HGNC:18395; SCGB1D1.
DR HPA; ENSG00000168515; Tissue enhanced (cervix).
DR MIM; 615060; gene.
DR neXtProt; NX_O95968; -.
DR OpenTargets; ENSG00000168515; -.
DR PharmGKB; PA34990; -.
DR VEuPathDB; HostDB:ENSG00000168515; -.
DR eggNOG; ENOG502SXZG; Eukaryota.
DR GeneTree; ENSGT00530000063866; -.
DR HOGENOM; CLU_166234_0_0_1; -.
DR InParanoid; O95968; -.
DR OMA; LALCCYD; -.
DR OrthoDB; 1634878at2759; -.
DR PhylomeDB; O95968; -.
DR TreeFam; TF338526; -.
DR PathwayCommons; O95968; -.
DR SignaLink; O95968; -.
DR BioGRID-ORCS; 10648; 16 hits in 1053 CRISPR screens.
DR GenomeRNAi; 10648; -.
DR Pharos; O95968; Tbio.
DR PRO; PR:O95968; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O95968; protein.
DR Bgee; ENSG00000168515; Expressed in right uterine tube and 30 other tissues.
DR Genevisible; O95968; HS.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR Pfam; PF01099; Uteroglobin; 1.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:25946035,
FT ECO:0000269|PubMed:9720917"
FT CHAIN 22..90
FT /note="Secretoglobin family 1D member 1"
FT /id="PRO_0000036378"
SQ SEQUENCE 90 AA; 9898 MW; DF2D4F7565A87D34 CRC64;
MRLSVCLLLL TLALCCYRAN AVVCQALGSE ITGFLLAGKP VFKFQLAKFK APLEAVAAKM
EVKKCVDTMA YEKRVLITKT LGKIAEKCDR
