ID   SG1D2_HUMAN             Reviewed;          90 AA.
AC   O95969; Q2M3N9;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Secretoglobin family 1D member 2;
DE   AltName: Full=Lipophilin-B;
DE   Flags: Precursor;
GN   Name=SCGB1D2; Synonyms=LIPHB, LPNB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10066439; DOI=10.1006/bbrc.1999.0274;
RA   Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.;
RT   "Lipophilins: human peptides homologous to rat prostatein.";
RL   Biochem. Biophys. Res. Commun. 256:147-155(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May bind androgens and other steroids, may also bind
CC       estramustine, a chemotherapeutic agent used for prostate cancer. May be
CC       under transcriptional regulation of steroid hormones.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highest expression was found in skeletal muscle.
CC       Expressed as well in thymus, trachea, kidney, steroid responsive
CC       tissues (prostate, testis, uterus, breast and ovary) and salivary
CC       gland.
CC   -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ224172; CAA11864.1; -; mRNA.
DR   EMBL; BC069290; AAH69290.1; -; mRNA.
DR   EMBL; BC104838; AAI04839.1; -; mRNA.
DR   EMBL; BC104840; AAI04841.1; -; mRNA.
DR   CCDS; CCDS8017.1; -.
DR   RefSeq; NP_006542.1; NM_006551.3.
DR   AlphaFoldDB; O95969; -.
DR   SMR; O95969; -.
DR   BioGRID; 115891; 30.
DR   IntAct; O95969; 9.
DR   STRING; 9606.ENSP00000244926; -.
DR   BioMuta; SCGB1D2; -.
DR   EPD; O95969; -.
DR   MassIVE; O95969; -.
DR   PaxDb; O95969; -.
DR   PeptideAtlas; O95969; -.
DR   PRIDE; O95969; -.
DR   ProteomicsDB; 51150; -.
DR   Antibodypedia; 28420; 142 antibodies from 21 providers.
DR   DNASU; 10647; -.
DR   Ensembl; ENST00000244926.4; ENSP00000244926.3; ENSG00000124935.4.
DR   GeneID; 10647; -.
DR   KEGG; hsa:10647; -.
DR   MANE-Select; ENST00000244926.4; ENSP00000244926.3; NM_006551.4; NP_006542.1.
DR   UCSC; uc001ntb.4; human.
DR   CTD; 10647; -.
DR   DisGeNET; 10647; -.
DR   GeneCards; SCGB1D2; -.
DR   HGNC; HGNC:18396; SCGB1D2.
DR   HPA; ENSG00000124935; Group enriched (breast, cervix).
DR   MIM; 615061; gene.
DR   neXtProt; NX_O95969; -.
DR   OpenTargets; ENSG00000124935; -.
DR   PharmGKB; PA34991; -.
DR   VEuPathDB; HostDB:ENSG00000124935; -.
DR   eggNOG; ENOG502SXZG; Eukaryota.
DR   GeneTree; ENSGT00530000063866; -.
DR   HOGENOM; CLU_166234_0_0_1; -.
DR   InParanoid; O95969; -.
DR   OMA; QFLFISE; -.
DR   OrthoDB; 1634878at2759; -.
DR   PhylomeDB; O95969; -.
DR   TreeFam; TF338526; -.
DR   PathwayCommons; O95969; -.
DR   SignaLink; O95969; -.
DR   BioGRID-ORCS; 10647; 8 hits in 1026 CRISPR screens.
DR   ChiTaRS; SCGB1D2; human.
DR   GeneWiki; SCGB1D2; -.
DR   GenomeRNAi; 10647; -.
DR   Pharos; O95969; Tbio.
DR   PRO; PR:O95969; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; O95969; protein.
DR   Bgee; ENSG00000124935; Expressed in right uterine tube and 109 other tissues.
DR   Genevisible; O95969; HS.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..90
FT                   /note="Secretoglobin family 1D member 2"
FT                   /id="PRO_0000036379"
FT   VARIANT         53
FT                   /note="P -> L (in dbSNP:rs2232950)"
FT                   /id="VAR_020254"
FT   VARIANT         80
FT                   /note="V -> A (in dbSNP:rs2276427)"
FT                   /id="VAR_020255"
SQ   SEQUENCE   90 AA;  9925 MW;  17BB555ED035D1AF CRC64;
     MKLSVCLLLV TLALCCYQAN AEFCPALVSE LLDFFFISEP LFKLSLAKFD APPEAVAAKL
     GVKRCTDQMS LQKRSLIAEV LVKILKKCSV