SG1D4_HUMAN
ID SG1D4_HUMAN Reviewed; 83 AA.
AC Q6XE38; A1L4Q8;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Secretoglobin family 1D member 4;
DE AltName: Full=IFN-gamma-inducible secretoglobin;
DE Short=IIS;
DE Flags: Precursor;
GN Name=SCGB1D4; ORFNames=UNQ517/PRO812;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION BY IFNG.
RX PubMed=15034037; DOI=10.4049/jimmunol.172.7.4245;
RA Choi M.S., Ray R., Zhang Z., Mukherjee A.B.;
RT "IFN-gamma stimulates the expression of a novel secretoglobin that
RT regulates chemotactic cell migration and invasion.";
RL J. Immunol. 172:4245-4252(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 22-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Seems to be involved in the regulation of chemotactic cell
CC migration and invasion.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in all tissues; the highest level of
CC expression is detectable in lymph nodes, tonsil, cultured lymphoblasts
CC and ovary. {ECO:0000269|PubMed:15034037}.
CC -!- INDUCTION: By IFNG/IFN-gamma. {ECO:0000269|PubMed:15034037}.
CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC {ECO:0000305}.
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DR EMBL; AY236538; AAP69948.1; -; mRNA.
DR EMBL; AY359052; AAQ89411.1; -; mRNA.
DR EMBL; CH471076; EAW74011.1; -; Genomic_DNA.
DR EMBL; BC130639; AAI30640.1; -; mRNA.
DR EMBL; BC130645; AAI30646.1; -; mRNA.
DR CCDS; CCDS31583.1; -.
DR RefSeq; NP_996881.1; NM_206998.1.
DR AlphaFoldDB; Q6XE38; -.
DR SMR; Q6XE38; -.
DR BioGRID; 135665; 28.
DR IntAct; Q6XE38; 26.
DR STRING; 9606.ENSP00000351395; -.
DR BioMuta; SCGB1D4; -.
DR DMDM; 55583904; -.
DR MassIVE; Q6XE38; -.
DR PaxDb; Q6XE38; -.
DR PeptideAtlas; Q6XE38; -.
DR PRIDE; Q6XE38; -.
DR DNASU; 404552; -.
DR Ensembl; ENST00000358585.3; ENSP00000351395.1; ENSG00000197745.3.
DR GeneID; 404552; -.
DR KEGG; hsa:404552; -.
DR MANE-Select; ENST00000358585.3; ENSP00000351395.1; NM_206998.2; NP_996881.1.
DR UCSC; uc001ntd.2; human.
DR CTD; 404552; -.
DR DisGeNET; 404552; -.
DR GeneCards; SCGB1D4; -.
DR HGNC; HGNC:31748; SCGB1D4.
DR HPA; ENSG00000197745; Group enriched (cervix, endometrium, epididymis, fallopian tube).
DR MIM; 615062; gene.
DR neXtProt; NX_Q6XE38; -.
DR OpenTargets; ENSG00000197745; -.
DR PharmGKB; PA142670946; -.
DR VEuPathDB; HostDB:ENSG00000197745; -.
DR eggNOG; ENOG502SXZG; Eukaryota.
DR GeneTree; ENSGT00530000063866; -.
DR HOGENOM; CLU_166234_0_0_1; -.
DR InParanoid; Q6XE38; -.
DR OMA; KLQVKHC; -.
DR OrthoDB; 1634878at2759; -.
DR PhylomeDB; Q6XE38; -.
DR TreeFam; TF338526; -.
DR PathwayCommons; Q6XE38; -.
DR SignaLink; Q6XE38; -.
DR BioGRID-ORCS; 404552; 8 hits in 1026 CRISPR screens.
DR GenomeRNAi; 404552; -.
DR Pharos; Q6XE38; Tdark.
DR PRO; PR:Q6XE38; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6XE38; protein.
DR Bgee; ENSG00000197745; Expressed in right uterine tube and 34 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR Pfam; PF01099; Uteroglobin; 1.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 22..83
FT /note="Secretoglobin family 1D member 4"
FT /id="PRO_0000036380"
SQ SEQUENCE 83 AA; 9201 MW; E6FD7DB7C757A202 CRC64;
MRLSVCLLMV SLALCCYQAH ALVCPAVASE ITVFLFLSDA AVNLQVAKLN PPPEALAAKL
EVKHCTDQIS FKKRLSLKKS WWK
