SG2A1_HUMAN
ID SG2A1_HUMAN Reviewed; 95 AA.
AC O75556;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Mammaglobin-B;
DE AltName: Full=Lacryglobin;
DE AltName: Full=Lipophilin-C;
DE AltName: Full=Mammaglobin-2;
DE AltName: Full=Secretoglobin family 2A member 1;
DE Flags: Precursor;
GN Name=SCGB2A1; Synonyms=LIPHC, MGB2, UGB3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9806831; DOI=10.1006/geno.1998.5539;
RA Becker R.M., Darrow C., Zimonjic D.B., Popescu N.C., Watson M.A.,
RA Fleming T.P.;
RT "Identification of mammaglobin B, a novel member of the uteroglobin gene
RT family.";
RL Genomics 54:70-78(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10066439; DOI=10.1006/bbrc.1999.0274;
RA Zhao C., Nguyen T., Yusifov T., Glasgow B.J., Lehrer R.I.;
RT "Lipophilins: human peptides homologous to rat prostatein.";
RL Biochem. Biophys. Res. Commun. 256:147-155(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 19-85.
RC TISSUE=Tear;
RX PubMed=9504814; DOI=10.1002/elps.1150181516;
RA Molloy M.P., Bolis S., Herbert B.R., Ou K., Tyler M.I., van Dyk D.D.,
RA Willcox M.D., Gooley A.A., Williams K.L., Morris C.A., Walsh B.J.;
RT "Establishment of the human reflex tear two-dimensional polyacrylamide gel
RT electrophoresis reference map: new proteins of potential diagnostic
RT value.";
RL Electrophoresis 18:2811-2815(1997).
RN [5]
RP PROTEIN SEQUENCE OF 19-46 AND 60-78, AND MASS SPECTROMETRY.
RC TISSUE=Tear;
RX PubMed=9720917; DOI=10.1016/s0014-5793(98)00852-7;
RA Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D.,
RA Glasgow B.J.;
RT "Lipophilin, a novel heterodimeric protein of human tears.";
RL FEBS Lett. 432:163-167(1998).
RN [6]
RP PROTEIN SEQUENCE OF 19-46 AND 84-95, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Tear;
RX PubMed=25946035; DOI=10.1021/acs.jproteome.5b00179;
RA Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I.,
RA Suarez T., Elortza F.;
RT "Human basal tear peptidome characterization by CID, HCD, and ETD followed
RT by in silico and in vitro analyses for antimicrobial peptide
RT identification.";
RL J. Proteome Res. 14:2649-2658(2015).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: May bind androgens and other steroids, may also bind
CC estramustine, a chemotherapeutic agent used for prostate cancer. May be
CC under transcriptional regulation of steroid hormones.
CC -!- SUBUNIT: Heterodimer of a lipophilin A and a lipophilin C (mammaglobin
CC B) monomer associated head to head.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in thymus, trachea, kidney, steroid
CC responsive tissues (prostate, testis, uterus, breast and ovary) and
CC salivary gland.
CC -!- MASS SPECTROMETRY: Mass=8854.94; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:9720917};
CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC {ECO:0000305}.
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DR EMBL; AF071219; AAC79996.1; -; mRNA.
DR EMBL; AJ224173; CAA11865.1; -; mRNA.
DR EMBL; BC062218; AAH62218.1; -; mRNA.
DR CCDS; CCDS8016.1; -.
DR RefSeq; NP_002398.1; NM_002407.2.
DR AlphaFoldDB; O75556; -.
DR SMR; O75556; -.
DR BioGRID; 110402; 144.
DR IntAct; O75556; 17.
DR STRING; 9606.ENSP00000244930; -.
DR GlyConnect; 1487; 2 N-Linked glycans (1 site).
DR GlyGen; O75556; 1 site, 2 N-linked glycans (1 site).
DR iPTMnet; O75556; -.
DR PhosphoSitePlus; O75556; -.
DR BioMuta; SCGB2A1; -.
DR CPTAC; CPTAC-1507; -.
DR MassIVE; O75556; -.
DR PaxDb; O75556; -.
DR PeptideAtlas; O75556; -.
DR PRIDE; O75556; -.
DR ProteomicsDB; 50084; -.
DR Antibodypedia; 28416; 213 antibodies from 31 providers.
DR DNASU; 4246; -.
DR Ensembl; ENST00000244930.6; ENSP00000244930.4; ENSG00000124939.6.
DR GeneID; 4246; -.
DR KEGG; hsa:4246; -.
DR MANE-Select; ENST00000244930.6; ENSP00000244930.4; NM_002407.3; NP_002398.1.
DR UCSC; uc001nta.2; human.
DR CTD; 4246; -.
DR DisGeNET; 4246; -.
DR GeneCards; SCGB2A1; -.
DR HGNC; HGNC:7051; SCGB2A1.
DR HPA; ENSG00000124939; Group enriched (cervix, epididymis).
DR MIM; 604398; gene.
DR neXtProt; NX_O75556; -.
DR OpenTargets; ENSG00000124939; -.
DR PharmGKB; PA34992; -.
DR VEuPathDB; HostDB:ENSG00000124939; -.
DR eggNOG; ENOG502TE00; Eukaryota.
DR GeneTree; ENSGT00390000013802; -.
DR HOGENOM; CLU_161063_0_0_1; -.
DR InParanoid; O75556; -.
DR OMA; YDSIWCN; -.
DR OrthoDB; 1529093at2759; -.
DR PhylomeDB; O75556; -.
DR TreeFam; TF338521; -.
DR PathwayCommons; O75556; -.
DR SignaLink; O75556; -.
DR BioGRID-ORCS; 4246; 18 hits in 1033 CRISPR screens.
DR ChiTaRS; SCGB2A1; human.
DR GeneWiki; Mammaglobin-B; -.
DR GenomeRNAi; 4246; -.
DR Pharos; O75556; Tbio.
DR PRO; PR:O75556; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O75556; protein.
DR Bgee; ENSG00000124939; Expressed in corpus epididymis and 108 other tissues.
DR Genevisible; O75556; HS.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0030521; P:androgen receptor signaling pathway; IDA:UniProtKB.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR Pfam; PF01099; Uteroglobin; 1.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:25946035,
FT ECO:0000269|PubMed:9504814, ECO:0000269|PubMed:9720917"
FT CHAIN 19..95
FT /note="Mammaglobin-B"
FT /id="PRO_0000036373"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 95 AA; 10884 MW; 0719738289F89F8D CRC64;
MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI DSDAAAEAMG
KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN
