SG2A2_HUMAN
ID SG2A2_HUMAN Reviewed; 93 AA.
AC Q13296; A1A522; Q86WH8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Mammaglobin-A;
DE AltName: Full=Mammaglobin-1;
DE AltName: Full=Secretoglobin family 2A member 2;
DE Flags: Precursor;
GN Name=SCGB2A2; Synonyms=MGB1, UGB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=8631025;
RA Watson M.A., Fleming T.P.;
RT "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is
RT overexpressed in human breast cancer.";
RL Cancer Res. 56:860-865(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=9488047; DOI=10.1038/sj.onc.1201597;
RA Watson M.A., Darrow C., Zimonjic D.B., Popescu N.C., Fleming T.;
RT "Structure and transcriptional regulation of the human mammaglobin gene, a
RT breast cancer associated member of the uteroglobin gene family localized to
RT chromosome 11q13.";
RL Oncogene 16:817-824(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Zhao L., Nan K.;
RT "An alternative splicing isoform of mammaglobin.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q13296; P50552: VASP; NbExp=3; IntAct=EBI-9058786, EBI-748201;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q13296-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13296-2; Sequence=VSP_009122;
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Over-expressed in breast
CC cancer.
CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC {ECO:0000305}.
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DR EMBL; U33147; AAC50375.1; -; mRNA.
DR EMBL; AF015224; AAC39608.1; -; Genomic_DNA.
DR EMBL; AY217100; AAO60111.1; -; mRNA.
DR EMBL; BC128252; AAI28253.1; -; mRNA.
DR EMBL; BC128402; AAI28403.1; -; mRNA.
DR CCDS; CCDS8018.1; -. [Q13296-1]
DR RefSeq; NP_002402.1; NM_002411.3. [Q13296-1]
DR AlphaFoldDB; Q13296; -.
DR SMR; Q13296; -.
DR BioGRID; 110406; 268.
DR IntAct; Q13296; 78.
DR MINT; Q13296; -.
DR STRING; 9606.ENSP00000227918; -.
DR GlyConnect; 1486; 26 N-Linked glycans (1 site).
DR GlyGen; Q13296; 2 sites, 25 N-linked glycans (1 site).
DR iPTMnet; Q13296; -.
DR PhosphoSitePlus; Q13296; -.
DR BioMuta; SCGB2A2; -.
DR DMDM; 2833243; -.
DR jPOST; Q13296; -.
DR MassIVE; Q13296; -.
DR PaxDb; Q13296; -.
DR PeptideAtlas; Q13296; -.
DR PRIDE; Q13296; -.
DR ProteomicsDB; 59286; -. [Q13296-1]
DR ProteomicsDB; 59287; -. [Q13296-2]
DR Antibodypedia; 28425; 403 antibodies from 40 providers.
DR DNASU; 4250; -.
DR Ensembl; ENST00000227918.3; ENSP00000227918.2; ENSG00000110484.7. [Q13296-1]
DR GeneID; 4250; -.
DR KEGG; hsa:4250; -.
DR MANE-Select; ENST00000227918.3; ENSP00000227918.2; NM_002411.4; NP_002402.1.
DR UCSC; uc001ntc.5; human. [Q13296-1]
DR CTD; 4250; -.
DR DisGeNET; 4250; -.
DR GeneCards; SCGB2A2; -.
DR HGNC; HGNC:7050; SCGB2A2.
DR HPA; ENSG00000110484; Tissue enriched (breast).
DR MIM; 605562; gene.
DR neXtProt; NX_Q13296; -.
DR OpenTargets; ENSG00000110484; -.
DR PharmGKB; PA34993; -.
DR VEuPathDB; HostDB:ENSG00000110484; -.
DR eggNOG; ENOG502TE5J; Eukaryota.
DR GeneTree; ENSGT00390000013802; -.
DR HOGENOM; CLU_161063_0_0_1; -.
DR InParanoid; Q13296; -.
DR OMA; IYDSSLC; -.
DR PhylomeDB; Q13296; -.
DR TreeFam; TF338521; -.
DR PathwayCommons; Q13296; -.
DR SignaLink; Q13296; -.
DR BioGRID-ORCS; 4250; 15 hits in 1064 CRISPR screens.
DR ChiTaRS; SCGB2A2; human.
DR GeneWiki; Mammaglobin-A; -.
DR GenomeRNAi; 4250; -.
DR Pharos; Q13296; Tbio.
DR PRO; PR:Q13296; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q13296; protein.
DR Bgee; ENSG00000110484; Expressed in upper leg skin and 95 other tissues.
DR ExpressionAtlas; Q13296; baseline and differential.
DR Genevisible; Q13296; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030521; P:androgen receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR Pfam; PF01099; Uteroglobin; 1.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..93
FT /note="Mammaglobin-A"
FT /id="PRO_0000036372"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 79..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_009122"
SQ SEQUENCE 93 AA; 10499 MW; 2896E8C43BF053E2 CRC64;
MKLLMVLMLA ALSQHCYAGS GCPLLENVIS KTINPQVSKT EYKELLQEFI DDNATTNAID
ELKECFLNQT DETLSNVEVF MQLIYDSSLC DLF
