SG2A2_RAT
ID SG2A2_RAT Reviewed; 95 AA.
AC P02780; Q63463;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Secretoglobin family 2A member 2;
DE AltName: Full=C3.1;
DE AltName: Full=Prostatein peptide C3;
DE AltName: Full=Prostatic steroid-binding protein C3;
DE Flags: Precursor;
GN Name=Scgb2a2; Synonyms=Psbpc3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=6685625; DOI=10.1002/j.1460-2075.1983.tb01498.x;
RA Hurst H.C., Parker M.G.;
RT "Rat prostatic steroid binding protein: DNA sequence and transcript maps of
RT the two C3 genes.";
RL EMBO J. 2:769-774(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6294095; DOI=10.1016/s0021-9258(18)33208-3;
RA Parker M.G., White R., Hurst H., Needham M., Tilly R.;
RT "Prostatic steroid-binding protein. Isolation and characterization of C3
RT genes.";
RL J. Biol. Chem. 258:12-15(1983).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=6190812; DOI=10.1016/s0021-9258(18)32135-5;
RA Viskochil D.H., Perry S.T., Lea O.A., Stafford D.W., Wilson E.M.,
RA French F.S.;
RT "Isolation of two genomic sequences encoding the Mr = 14,000 subunit of rat
RT prostatein.";
RL J. Biol. Chem. 258:8861-8866(1983).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1537831; DOI=10.1016/s0021-9258(18)42855-4;
RA Tan J.A., Marschke K.B., Ho K.-C., Perry S.T., Wilson E.M., French F.S.;
RT "Response elements of the androgen-regulated C3 gene.";
RL J. Biol. Chem. 267:4456-4466(1992).
RN [5]
RP ERRATUM OF PUBMED:1537831.
RX PubMed=1339454; DOI=10.1016/s0021-9258(18)42608-7;
RA Tan J.A., Marschke K.B., Ho K.C., Perry S.T., Wilson E.M., French F.S.;
RL J. Biol. Chem. 267:7958-7958(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 19-95.
RX PubMed=7014218;
RA Peeters B., Rombauts W., Mous J., Heyns W.;
RT "Structural studies on rat prostatic binding protein. The primary structure
RT of its glycosylated component C3.";
RL Eur. J. Biochem. 115:115-121(1981).
CC -!- FUNCTION: Part of prostatein which is the major secretory glycoprotein
CC of ventral prostate gland. Steroid-binding protein; can bind non-polar
CC steroids, cholesterol and a group of small proline-rich peptides.
CC -!- SUBUNIT: Prostatein is composed of three different peptides called C1,
CC C2 and C3. These form covalent C1:C3 (F) and C2:C3 (S) heterodimers
CC whose non-covalent association forms tetrameric (C1:C3/C3:C2)
CC prostatein molecules.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in ventral prostate.
CC {ECO:0000269|PubMed:6685625}.
CC -!- INDUCTION: Androgen dependent, as shown by the decrease in the level of
CC the protein following castration. {ECO:0000269|PubMed:6685625}.
CC -!- SIMILARITY: Belongs to the secretoglobin family. Lipophilin subfamily.
CC {ECO:0000305}.
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DR EMBL; V01257; CAB76237.1; -; Genomic_DNA.
DR EMBL; V01258; CAB76237.1; JOINED; Genomic_DNA.
DR EMBL; V01259; CAB76237.1; JOINED; Genomic_DNA.
DR EMBL; V01263; CAA24577.1; -; mRNA.
DR EMBL; M71245; AAA41965.1; -; Genomic_DNA.
DR EMBL; BC062401; AAH62401.1; -; mRNA.
DR PIR; A92395; BORT3.
DR RefSeq; NP_976078.1; NM_203333.2.
DR RefSeq; XP_017445787.1; XM_017590298.1.
DR AlphaFoldDB; P02780; -.
DR SMR; P02780; -.
DR STRING; 10116.ENSRNOP00000037869; -.
DR GlyGen; P02780; 1 site.
DR iPTMnet; P02780; -.
DR PhosphoSitePlus; P02780; -.
DR PaxDb; P02780; -.
DR Ensembl; ENSRNOT00000031612; ENSRNOP00000037869; ENSRNOG00000023151.
DR GeneID; 361725; -.
DR KEGG; rno:361725; -.
DR UCSC; RGD:735031; rat.
DR CTD; 4246; -.
DR RGD; 735031; Scgb2a2.
DR eggNOG; ENOG502TE5J; Eukaryota.
DR GeneTree; ENSGT00390000013802; -.
DR HOGENOM; CLU_161063_0_0_1; -.
DR InParanoid; P02780; -.
DR OMA; IYDSSLC; -.
DR OrthoDB; 1529093at2759; -.
DR PhylomeDB; P02780; -.
DR TreeFam; TF338521; -.
DR PRO; PR:P02780; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020305; Expressed in pancreas and 3 other tissues.
DR Genevisible; P02780; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; TAS:RGD.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0030521; P:androgen receptor signaling pathway; ISO:RGD.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR035960; Secretoglobin_sf.
DR Pfam; PF01099; Uteroglobin; 1.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Lipid-binding; Reference proteome;
KW Secreted; Signal; Steroid-binding.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:7014218"
FT CHAIN 19..95
FT /note="Secretoglobin family 2A member 2"
FT /id="PRO_0000036377"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:7014218"
FT CONFLICT 53
FT /note="D -> A (in Ref. 4; AAA41965)"
FT /evidence="ECO:0000305"
FT CONFLICT 79
FT /note="G -> S (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 95 AA; 10731 MW; F7F7F1A0C882E375 CRC64;
MKLVFLFLLV TIPICCYASG SGCSILDEVI RGTINSTVTL HDYMKLVKPY VQDHFTEKAV
KQFKQCFLDQ TDKTLENVGV MMEAIFNSES CQQPS
