SG3A1_HUMAN
ID SG3A1_HUMAN Reviewed; 104 AA.
AC Q96QR1; Q96PL0;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Secretoglobin family 3A member 1;
DE AltName: Full=Cytokine HIN-1;
DE AltName: Full=High in normal 1;
DE AltName: Full=Pneumo secretory protein 2;
DE Short=PnSP-2;
DE AltName: Full=Uteroglobin-related protein 2;
DE Flags: Precursor;
GN Name=SCGB3A1; Synonyms=HIN1, PNSP2, UGRP2; ORFNames=UNQ629/PRO1245;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=11481438; DOI=10.1073/pnas.171138398;
RA Krop I.E., Sgroi D., Porter D.A., Lunetta K.L., LeVangie R., Seth P.,
RA Kaelin C.M., Rhei E., Bosenberg M., Schnitt S., Marks J.R., Pagon Z.,
RA Belina D., Razumovic J., Polyak K.;
RT "HIN-1, a putative cytokine highly expressed in normal but not cancerous
RT mammary epithelial cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9796-9801(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11682631; DOI=10.1210/mend.15.11.0728;
RA Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C.,
RA Kimura S.;
RT "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a
RT novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain
RT transcription factor.";
RL Mol. Endocrinol. 15:2021-2036(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Clippe A., Laing I.A., LeSouef P.N., Bernard A., Knoops B.;
RT "Molecular cloning of PnSP-1, a protein of the respiratory tract with
RT potential association to atopy.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 21-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=12406855; DOI=10.1164/rccm.200204-285oc;
RA Reynolds S.D., Reynolds P.R., Pryhuber G.S., Finder J.D., Stripp B.R.;
RT "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse
RT and human airways.";
RL Am. J. Respir. Crit. Care Med. 166:1498-1509(2002).
CC -!- FUNCTION: Secreted cytokine-like protein. Inhibits cell growth in
CC vitro. {ECO:0000269|PubMed:11481438}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:Q920H1}.
CC -!- INTERACTION:
CC Q96QR1; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-9057632, EBI-17589229;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11481438}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung and prostate
CC (PubMed:11481438). Also found in mammary gland, spleen, pancreas,
CC testis and liver (PubMed:11481438). Detected throughout the airway
CC epithelium in lung, with highest expression in large airways
CC (PubMed:12406855). Found in lung submucosal glands where it localizes
CC to acinar and ductile cells (PubMed:12406855). Not detected in
CC respiratory bronchioles, alveolar ducts or alveolar epithelium
CC (PubMed:12406855). In mammary gland, specifically localizes to luminal
CC epithelial cells (PubMed:11481438). {ECO:0000269|PubMed:11481438,
CC ECO:0000269|PubMed:12406855}.
CC -!- SIMILARITY: Belongs to the secretoglobin family. UGRP subfamily.
CC {ECO:0000305}.
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DR EMBL; AY040564; AAK82942.1; -; mRNA.
DR EMBL; AF313458; AAL26217.1; -; mRNA.
DR EMBL; AF436839; AAQ04481.1; -; mRNA.
DR EMBL; AY359064; AAQ89423.1; -; mRNA.
DR EMBL; BC029176; AAH29176.1; -; mRNA.
DR EMBL; BC072673; AAH72673.1; -; mRNA.
DR CCDS; CCDS4456.1; -.
DR RefSeq; NP_443095.2; NM_052863.2.
DR AlphaFoldDB; Q96QR1; -.
DR BioGRID; 124931; 19.
DR IntAct; Q96QR1; 8.
DR MINT; Q96QR1; -.
DR STRING; 9606.ENSP00000292641; -.
DR GlyGen; Q96QR1; 2 sites, 1 O-linked glycan (2 sites).
DR BioMuta; SCGB3A1; -.
DR DMDM; 46397901; -.
DR MassIVE; Q96QR1; -.
DR PaxDb; Q96QR1; -.
DR PeptideAtlas; Q96QR1; -.
DR PRIDE; Q96QR1; -.
DR ProteomicsDB; 77887; -.
DR Antibodypedia; 29609; 127 antibodies from 20 providers.
DR DNASU; 92304; -.
DR Ensembl; ENST00000292641.4; ENSP00000292641.3; ENSG00000161055.4.
DR GeneID; 92304; -.
DR KEGG; hsa:92304; -.
DR MANE-Select; ENST00000292641.4; ENSP00000292641.3; NM_052863.3; NP_443095.2.
DR UCSC; uc003mly.4; human.
DR CTD; 92304; -.
DR DisGeNET; 92304; -.
DR GeneCards; SCGB3A1; -.
DR HGNC; HGNC:18384; SCGB3A1.
DR HPA; ENSG00000161055; Group enriched (cervix, lung, salivary gland).
DR MIM; 606500; gene.
DR neXtProt; NX_Q96QR1; -.
DR OpenTargets; ENSG00000161055; -.
DR PharmGKB; PA34994; -.
DR VEuPathDB; HostDB:ENSG00000161055; -.
DR eggNOG; ENOG502T3N5; Eukaryota.
DR GeneTree; ENSGT00420000029848; -.
DR HOGENOM; CLU_146812_1_0_1; -.
DR InParanoid; Q96QR1; -.
DR OMA; NPLKFML; -.
DR PhylomeDB; Q96QR1; -.
DR TreeFam; TF336928; -.
DR PathwayCommons; Q96QR1; -.
DR SignaLink; Q96QR1; -.
DR BioGRID-ORCS; 92304; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; SCGB3A1; human.
DR GeneWiki; SCGB3A1; -.
DR GenomeRNAi; 92304; -.
DR Pharos; Q96QR1; Tbio.
DR PRO; PR:Q96QR1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96QR1; protein.
DR Bgee; ENSG00000161055; Expressed in trachea and 138 other tissues.
DR Genevisible; Q96QR1; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; NAS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; NAS:UniProtKB.
DR InterPro; IPR040301; Secretoglobin_3A.
DR PANTHER; PTHR34829; PTHR34829; 1.
PE 1: Evidence at protein level;
KW Cytokine; Direct protein sequencing; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 21..104
FT /note="Secretoglobin family 3A member 1"
FT /id="PRO_0000036383"
FT DISULFID 78
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:Q920H1"
FT CONFLICT 19
FT /note="A -> R (in Ref. 1; AAK82942)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 104 AA; 10100 MW; C1A0951F8FB1455F CRC64;
MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP LGTLNPLKLL
LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL TVFG
