SG3A1_MOUSE
ID SG3A1_MOUSE Reviewed; 104 AA.
AC Q920D7;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Secretoglobin family 3A member 1;
DE AltName: Full=Cytokine HIN-1;
DE AltName: Full=High in normal 1;
DE AltName: Full=Pneumo secretory protein 2;
DE Short=PnSP-2;
DE AltName: Full=Uteroglobin-related protein 2;
DE Flags: Precursor;
GN Name=Scgb3a1; Synonyms=Hin1, Pnsp2, Ugrp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11481438; DOI=10.1073/pnas.171138398;
RA Krop I.E., Sgroi D., Porter D.A., Lunetta K.L., LeVangie R., Seth P.,
RA Kaelin C.M., Rhei E., Bosenberg M., Schnitt S., Marks J.R., Pagon Z.,
RA Belina D., Razumovic J., Polyak K.;
RT "HIN-1, a putative cytokine highly expressed in normal but not cancerous
RT mammary epithelial cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9796-9801(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11682631; DOI=10.1210/mend.15.11.0728;
RA Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C.,
RA Kimura S.;
RT "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a
RT novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain
RT transcription factor.";
RL Mol. Endocrinol. 15:2021-2036(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI;
RA Clippe A., Laing I.A., LeSouef P.N., Bernard A., Knoops B.;
RT "Molecular cloning of PnSP-1, a protein of the respiratory tract with
RT potential association to atopy.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12406855; DOI=10.1164/rccm.200204-285oc;
RA Reynolds S.D., Reynolds P.R., Pryhuber G.S., Finder J.D., Stripp B.R.;
RT "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse
RT and human airways.";
RL Am. J. Respir. Crit. Care Med. 166:1498-1509(2002).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12175512; DOI=10.1016/s0925-4773(02)00056-4;
RA Porter D., Lahti-Domenici J., Torres-Arzayus M., Chin L., Polyak K.;
RT "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1
RT (UGRP-1) in adult and developing tissues.";
RL Mech. Dev. 114:201-204(2002).
CC -!- FUNCTION: Secreted cytokine-like protein. Inhibits cell growth in
CC vitro. {ECO:0000250|UniProtKB:Q96QR1}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:Q920H1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96QR1}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung, where it localizes to
CC epithelial cells lining the trachea and bronchi (PubMed:12406855,
CC PubMed:12175512). Expression in lung is mainly restricted to bronchi,
CC submucosal glands of the trachea, and tracheal epithelium, with little
CC expression in terminal bronchioles (PubMed:12406855). Expressed in
CC uterus where it localizes to epithelial cells of the uterine glands
CC (PubMed:12175512). Also detected in heart, stomach and small intestine
CC (PubMed:12175512). {ECO:0000269|PubMed:12175512,
CC ECO:0000269|PubMed:12406855}.
CC -!- DEVELOPMENTAL STAGE: Detected in lung at embryonic stage 18.5 dpc.
CC During gestation, expressed in the mammary gland from 6.5 dpc with
CC highest expression at 10.5 dpc. Expression then declines, but later
CC increases again during mammary gland involution at 4-21 days post
CC partum. {ECO:0000269|PubMed:12175512}.
CC -!- SIMILARITY: Belongs to the secretoglobin family. UGRP subfamily.
CC {ECO:0000305}.
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DR EMBL; AF313456; AAL26216.1; -; mRNA.
DR EMBL; AF436840; AAQ04482.1; -; mRNA.
DR CCDS; CCDS24619.1; -.
DR RefSeq; NP_473378.1; NM_054037.2.
DR AlphaFoldDB; Q920D7; -.
DR STRING; 10090.ENSMUSP00000043325; -.
DR MaxQB; Q920D7; -.
DR PaxDb; Q920D7; -.
DR PRIDE; Q920D7; -.
DR ProteomicsDB; 257214; -.
DR Antibodypedia; 29609; 127 antibodies from 20 providers.
DR DNASU; 68662; -.
DR Ensembl; ENSMUST00000043873; ENSMUSP00000043325; ENSMUSG00000064057.
DR GeneID; 68662; -.
DR KEGG; mmu:68662; -.
DR UCSC; uc007iqw.2; mouse.
DR CTD; 92304; -.
DR MGI; MGI:1915912; Scgb3a1.
DR VEuPathDB; HostDB:ENSMUSG00000064057; -.
DR eggNOG; ENOG502T3N5; Eukaryota.
DR GeneTree; ENSGT00420000029848; -.
DR HOGENOM; CLU_146812_1_0_1; -.
DR InParanoid; Q920D7; -.
DR OMA; NPLKFML; -.
DR OrthoDB; 1596324at2759; -.
DR PhylomeDB; Q920D7; -.
DR TreeFam; TF336928; -.
DR BioGRID-ORCS; 68662; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Scgb3a1; mouse.
DR PRO; PR:Q920D7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q920D7; protein.
DR Bgee; ENSMUSG00000064057; Expressed in trachea and 64 other tissues.
DR ExpressionAtlas; Q920D7; baseline and differential.
DR Genevisible; Q920D7; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IMP:MGI.
DR InterPro; IPR040301; Secretoglobin_3A.
DR PANTHER; PTHR34829; PTHR34829; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250|UniProtKB:Q96QR1"
FT CHAIN 22..104
FT /note="Secretoglobin family 3A member 1"
FT /id="PRO_0000036384"
FT DISULFID 81
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:Q920H1"
SQ SEQUENCE 104 AA; 10591 MW; D62F0E601FB57A6D CRC64;
MKLTTTFLVL CVALLSDSGV AFFMDSLAKP AVEPVAALAP AAEAVAGAVP SLPLSHLAIL
RFILASMGIP LDPLIEGSRK CVTELGPEAV GAVKSLLGVL TMFG
