SG3A2_HUMAN
ID SG3A2_HUMAN Reviewed; 93 AA.
AC Q96PL1;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Secretoglobin family 3A member 2;
DE AltName: Full=Pneumo secretory protein 1;
DE Short=PnSP-1;
DE AltName: Full=Uteroglobin-related protein 1;
DE Flags: Precursor;
GN Name=SCGB3A2; Synonyms=PNSP1, UGRP1; ORFNames=UNQ566/PRO1128;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11682631; DOI=10.1210/mend.15.11.0728;
RA Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C.,
RA Kimura S.;
RT "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a
RT novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain
RT transcription factor.";
RL Mol. Endocrinol. 15:2021-2036(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Clippe A., Laing I.A., LeSouef P.N., Bernard A., Knoops B.;
RT "Molecular cloning of PnSP-1, a protein of the respiratory tract with
RT potential association to atopy.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12406855; DOI=10.1164/rccm.200204-285oc;
RA Reynolds S.D., Reynolds P.R., Pryhuber G.S., Finder J.D., Stripp B.R.;
RT "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse
RT and human airways.";
RL Am. J. Respir. Crit. Care Med. 166:1498-1509(2002).
RN [6]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=12175512; DOI=10.1016/s0925-4773(02)00056-4;
RA Porter D., Lahti-Domenici J., Torres-Arzayus M., Chin L., Polyak K.;
RT "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1
RT (UGRP-1) in adult and developing tissues.";
RL Mech. Dev. 114:201-204(2002).
RN [7]
RP FUNCTION, INTERACTION WITH APOA1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND SIGNAL SEQUENCE CLEAVAGE SITE.
RX PubMed=12847263; DOI=10.4049/jimmunol.171.2.924;
RA Bin L.H., Nielson L.D., Liu X., Mason R.J., Shu H.B.;
RT "Identification of uteroglobin-related protein 1 and macrophage scavenger
RT receptor with collagenous structure as a lung-specific ligand-receptor
RT pair.";
RL J. Immunol. 171:924-930(2003).
RN [8]
RP FUNCTION, AND SUBUNIT.
RX PubMed=24213919; DOI=10.1152/ajplung.00037.2013;
RA Cai Y., Winn M.E., Zehmer J.K., Gillette W.K., Lubkowski J.T., Pilon A.L.,
RA Kimura S.;
RT "Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung
RT development and fibrosis.";
RL Am. J. Physiol. 306:L10-L22(2014).
RN [9]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-33.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Secreted cytokine-like protein (PubMed:12847263). Binds to
CC the scavenger receptor MARCO (PubMed:12847263). Can also bind to
CC pathogens including the Gram-positive bacterium L.monocytogenes, the
CC Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263).
CC Strongly inhibits phospholipase A2 (PLA2G1B) activity
CC (PubMed:24213919). Seems to have anti-inflammatory effects in
CC respiratory epithelium (By similarity). Also has anti-fibrotic activity
CC in lung (PubMed:24213919). May play a role in fetal lung development
CC and maturation (PubMed:24213919). Promotes branching morphogenesis
CC during early stages of lung development (PubMed:24213919). In the
CC pituitary, may inhibit production of follicle-stimulating hormone (FSH)
CC and luteinizing hormone (LH) (By similarity).
CC {ECO:0000250|UniProtKB:Q920H1, ECO:0000269|PubMed:12847263,
CC ECO:0000269|PubMed:24213919}.
CC -!- SUBUNIT: Homodimer; disulfide-linked (PubMed:24213919). Monomer
CC (PubMed:24213919). Interacts with APOA1 (PubMed:12847263).
CC {ECO:0000269|PubMed:12847263, ECO:0000269|PubMed:24213919}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12847263}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung and trachea
CC (PubMed:12406855, PubMed:12175512, PubMed:12847263). Detected
CC throughout the airway epithelium in lung, with slightly higher
CC expression in large airways (PubMed:12406855). Found in lung submucosal
CC gland acinus where it localizes to serous-like cells (PubMed:12406855).
CC Probably expressed in club/Clara cells of the bronchioles
CC (PubMed:12847263). Not detected in other tissues tested
CC (PubMed:12847263). {ECO:0000269|PubMed:12175512,
CC ECO:0000269|PubMed:12406855, ECO:0000269|PubMed:12847263}.
CC -!- DEVELOPMENTAL STAGE: Expressed in fetal lung.
CC {ECO:0000269|PubMed:12175512}.
CC -!- SIMILARITY: Belongs to the secretoglobin family. UGRP subfamily.
CC {ECO:0000305}.
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DR EMBL; AF313455; AAL26215.1; -; mRNA.
DR EMBL; AF439544; AAQ04559.1; -; Genomic_DNA.
DR EMBL; AF439545; AAQ04560.1; -; mRNA.
DR EMBL; AY358979; AAQ89338.1; -; mRNA.
DR EMBL; BC024232; AAH24232.1; -; mRNA.
DR CCDS; CCDS4287.1; -.
DR RefSeq; NP_473364.1; NM_054023.4.
DR AlphaFoldDB; Q96PL1; -.
DR BioGRID; 125562; 1.
DR STRING; 9606.ENSP00000296694; -.
DR iPTMnet; Q96PL1; -.
DR PhosphoSitePlus; Q96PL1; -.
DR BioMuta; SCGB3A2; -.
DR MassIVE; Q96PL1; -.
DR PaxDb; Q96PL1; -.
DR PeptideAtlas; Q96PL1; -.
DR PRIDE; Q96PL1; -.
DR ProteomicsDB; 77706; -.
DR Antibodypedia; 27663; 51 antibodies from 16 providers.
DR DNASU; 117156; -.
DR Ensembl; ENST00000296694.5; ENSP00000296694.4; ENSG00000164265.9.
DR GeneID; 117156; -.
DR KEGG; hsa:117156; -.
DR MANE-Select; ENST00000296694.5; ENSP00000296694.4; NM_054023.5; NP_473364.1.
DR UCSC; uc003lot.3; human.
DR CTD; 117156; -.
DR DisGeNET; 117156; -.
DR GeneCards; SCGB3A2; -.
DR HGNC; HGNC:18391; SCGB3A2.
DR HPA; ENSG00000164265; Tissue enriched (lung).
DR MalaCards; SCGB3A2; -.
DR MIM; 606531; gene.
DR neXtProt; NX_Q96PL1; -.
DR OpenTargets; ENSG00000164265; -.
DR PharmGKB; PA34995; -.
DR VEuPathDB; HostDB:ENSG00000164265; -.
DR eggNOG; ENOG502SVJM; Eukaryota.
DR GeneTree; ENSGT00420000029848; -.
DR HOGENOM; CLU_146812_0_0_1; -.
DR InParanoid; Q96PL1; -.
DR OMA; NSVLPFM; -.
DR PhylomeDB; Q96PL1; -.
DR TreeFam; TF336928; -.
DR PathwayCommons; Q96PL1; -.
DR Reactome; R-HSA-3000480; Scavenging by Class A Receptors.
DR SignaLink; Q96PL1; -.
DR BioGRID-ORCS; 117156; 4 hits in 1062 CRISPR screens.
DR GeneWiki; SCGB3A2; -.
DR GenomeRNAi; 117156; -.
DR Pharos; Q96PL1; Tbio.
DR PRO; PR:Q96PL1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96PL1; protein.
DR Bgee; ENSG00000164265; Expressed in trachea and 115 other tissues.
DR ExpressionAtlas; Q96PL1; baseline and differential.
DR Genevisible; Q96PL1; HS.
DR GO; GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR InterPro; IPR040301; Secretoglobin_3A.
DR PANTHER; PTHR34829; PTHR34829; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:12847263"
FT CHAIN 22..93
FT /note="Secretoglobin family 3A member 2"
FT /id="PRO_0000036381"
FT DISULFID 70
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:Q920H1"
FT VARIANT 33
FT /note="K -> N (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036185"
SQ SEQUENCE 93 AA; 10161 MW; FBD4BFAC2BF33718 CRC64;
MKLVTIFLLV TISLCSYSAT AFLINKVPLP VDKLAPLPLD NILPFMDPLK LLLKTLGISV
EHLVEGLRKC VNELGPEASE AVKKLLEALS HLV
