SGCA_ECOLI
ID SGCA_ECOLI Reviewed; 143 AA.
AC P39363; Q2M613;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Putative phosphotransferase IIA component SgcA;
DE AltName: Full=Putative PTS system EIIA component;
GN Name=sgcA; Synonyms=yjhL; OrderedLocusNames=b4302, JW4264;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP DISCUSSION OF SEQUENCE.
RA Reizer J., Charbit A., Reizer A., Saier M.H. Jr.;
RT "Novel phosphotransferases system genes revealed by bacterial genome
RT analysis: operons encoding homologues of sugar-specific permease domains of
RT the phosphotransferase system and pentose catabolic enzymes.";
RL Genome Sci. Technol. 1:53-75(1996).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active -transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DOMAIN: The EIIA domain is phosphorylated by phospho-HPr on a histidyl
CC residue. Then, it transfers the phosphoryl group to the EIIB domain.
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DR EMBL; U14003; AAA97198.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77258.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78293.1; -; Genomic_DNA.
DR PIR; H65243; H65243.
DR RefSeq; NP_418722.1; NC_000913.3.
DR RefSeq; WP_000606406.1; NZ_SSUV01000012.1.
DR AlphaFoldDB; P39363; -.
DR SMR; P39363; -.
DR BioGRID; 4261489; 8.
DR BioGRID; 853111; 5.
DR ComplexPortal; CPX-5990; sgcABC sugar permease enzyme II complex.
DR IntAct; P39363; 7.
DR STRING; 511145.b4302; -.
DR TCDB; 4.A.5.1.3; the pts galactitol (gat) family.
DR jPOST; P39363; -.
DR PaxDb; P39363; -.
DR PRIDE; P39363; -.
DR EnsemblBacteria; AAC77258; AAC77258; b4302.
DR EnsemblBacteria; BAE78293; BAE78293; BAE78293.
DR GeneID; 948831; -.
DR KEGG; ecj:JW4264; -.
DR KEGG; eco:b4302; -.
DR PATRIC; fig|1411691.4.peg.2395; -.
DR EchoBASE; EB2442; -.
DR eggNOG; COG1762; Bacteria.
DR HOGENOM; CLU_072531_2_0_6; -.
DR OMA; GPWYILS; -.
DR PhylomeDB; P39363; -.
DR BioCyc; EcoCyc:SGCA-MON; -.
DR BioCyc; MetaCyc:SGCA-MON; -.
DR PRO; PR:P39363; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1902495; C:transmembrane transporter complex; IC:ComplexPortal.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IC:ComplexPortal.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IC:ComplexPortal.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0015795; P:sorbitol transmembrane transport; IC:ComplexPortal.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR Gene3D; 3.40.930.10; -; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR SUPFAM; SSF55804; SSF55804; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Kinase; Phosphotransferase system; Reference proteome;
KW Sugar transport; Transferase; Transport.
FT CHAIN 1..143
FT /note="Putative phosphotransferase IIA component SgcA"
FT /id="PRO_0000186689"
FT DOMAIN 1..143
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00417"
FT ACT_SITE 63
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00417"
SQ SEQUENCE 143 AA; 15638 MW; 24F59C5C4C3BC56A CRC64;
MINDIKWVQA QRKATDWRQA VEIATRPLVA YGAAQPCYVN GIIENTLNWG PYYLIAPGIA
LPHARPEQGA NYNQVSITTL RTPVAFGNEE CDPVWLLLCV SATDANAHIL TIQRISQFID
SPQRLTAVGN ASTDDALFAL VSG
