ID   SGCB_BOVIN              Reviewed;         317 AA.
AC   A6QP70;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Beta-sarcoglycan;
DE            Short=Beta-SG;
GN   Name=SGCB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC       dystrophin-glycoprotein complex which forms a link between the F-actin
CC       cytoskeleton and the extracellular matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Cross-link to form 2 major subcomplexes: one consisting of
CC       SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The
CC       association between SGCB and SGCG is particularly strong while SGCA is
CC       loosely associated with the other sarcoglycans (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- PTM: Disulfide bonds are present. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC       {ECO:0000305}.
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DR   EMBL; BC149178; AAI49179.1; -; mRNA.
DR   RefSeq; NP_001095658.1; NM_001102188.1.
DR   AlphaFoldDB; A6QP70; -.
DR   STRING; 9913.ENSBTAP00000052639; -.
DR   PaxDb; A6QP70; -.
DR   Ensembl; ENSBTAT00000078968; ENSBTAP00000069298; ENSBTAG00000014601.
DR   GeneID; 535372; -.
DR   KEGG; bta:535372; -.
DR   CTD; 6443; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014601; -.
DR   VGNC; VGNC:34536; SGCB.
DR   eggNOG; ENOG502QUW4; Eukaryota.
DR   GeneTree; ENSGT00390000008110; -.
DR   HOGENOM; CLU_066515_1_0_1; -.
DR   InParanoid; A6QP70; -.
DR   OrthoDB; 1214843at2759; -.
DR   TreeFam; TF313538; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000014601; Expressed in cardiac ventricle and 102 other tissues.
DR   ExpressionAtlas; A6QP70; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016012; C:sarcoglycan complex; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR   InterPro; IPR006875; Sarcoglycan.
DR   InterPro; IPR027659; Sgcb.
DR   PANTHER; PTHR21142; PTHR21142; 1.
DR   Pfam; PF04790; Sarcoglycan_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="Beta-sarcoglycan"
FT                   /id="PRO_0000326142"
FT   TOPO_DOM        1..64
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..317
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        287..313
FT                   /evidence="ECO:0000255"
FT   DISULFID        289..306
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  34734 MW;  9DE3D0DFD15E0030 CRC64;
     MAAAAAATEQ QSSNGPVKKS MREKAVERRN VNKEHNSNFK AGYIPIDEDR LHKTGLRGRK
     GNLAICVIVL LFILAVINLI ITLVIWAVIR IGPNGCDSME FHESGLLRFK QVSDMGVIHP
     LYKSTVGGRR NENLVITGNN QPIVFQQGTT KLSVGKNKTS ITSDTGMQFF DPRTQNILFS
     TDYETHEFHL PSGVKSLNVQ KASTERITSN ATSDLNIKVG GRAIVRGNEG VFIMGKTIQF
     HMGGNMELKA ENSIILNGTV MVSTNRLPSS SSGDQFGGDD WVRYKLCMCA DGTLFRVQVT
     GQNMGCQTSD NPCGDLY