ID   SGCB_PONAB              Reviewed;         319 AA.
AC   Q5R9U1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Beta-sarcoglycan;
DE            Short=Beta-SG;
GN   Name=SGCB;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC       dystrophin-glycoprotein complex which forms a link between the F-actin
CC       cytoskeleton and the extracellular matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Cross-link to form 2 major subcomplexes: one consisting of
CC       SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The
CC       association between SGCB and SGCG is particularly strong while SGCA is
CC       loosely associated with the other sarcoglycans (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- PTM: Disulfide bonds are present. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859291; CAH91469.1; -; mRNA.
DR   RefSeq; NP_001125865.1; NM_001132393.1.
DR   AlphaFoldDB; Q5R9U1; -.
DR   STRING; 9601.ENSPPYP00000016507; -.
DR   Ensembl; ENSPPYT00000017182; ENSPPYP00000016507; ENSPPYG00000014780.
DR   GeneID; 100172796; -.
DR   KEGG; pon:100172796; -.
DR   CTD; 6443; -.
DR   eggNOG; ENOG502QUW4; Eukaryota.
DR   GeneTree; ENSGT00390000008110; -.
DR   InParanoid; Q5R9U1; -.
DR   OrthoDB; 1214843at2759; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016012; C:sarcoglycan complex; IEA:Ensembl.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR   GO; GO:0097084; P:vascular associated smooth muscle cell development; IEA:Ensembl.
DR   InterPro; IPR006875; Sarcoglycan.
DR   InterPro; IPR027659; Sgcb.
DR   PANTHER; PTHR21142; PTHR21142; 1.
DR   Pfam; PF04790; Sarcoglycan_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Beta-sarcoglycan"
FT                   /id="PRO_0000326143"
FT   TOPO_DOM        1..66
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..318
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        259
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        289..315
FT                   /evidence="ECO:0000255"
FT   DISULFID        291..308
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  34875 MW;  81C8CEBB83D220D5 CRC64;
     MAAAAAAAAA EQQSSNGPVK KSMREKAVER RNVNKEHNSN FKAGYIPIDE DRLHKTGLRG
     RKGNLAICVI ILLFILAVIN LIITLVIWAV IRIGPNGCDS MEFHESGLLR FKQVSDMGVI
     HPLYKSTVGG RRNENLVITG NNQPIVFQQG TTKLSVENNK TSITSDIGMQ FFDPRTQNIL
     FSTDYETHEF HLPSGVKSLN VQKASTERIT SNATSDLNIK VDGRAIVRGN EGVFIMGKTI
     EFHMGGNMEL KAENSIILNG SVMVSTTRLP SSSSGDQLGS GDWVRYKLCM CADGTLFKVQ
     VTSQNMGCQI SDNPCGNTH