SGCC_ECOLI
ID SGCC_ECOLI Reviewed; 437 AA.
AC P39365; Q2M611;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative permease IIC component;
DE AltName: Full=Putative PTS system EIIC component;
GN Name=sgcC; Synonyms=yjhN; OrderedLocusNames=b4304, JW4266;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP DISCUSSION OF SEQUENCE.
RA Reizer J., Charbit A., Reizer A., Saier M.H. Jr.;
RT "Novel phosphotransferases system genes revealed by bacterial genome
RT analysis: operons encoding homologues of sugar-specific permease domains of
RT the phosphotransferase system and pentose catabolic enzymes.";
RL Genome Sci. Technol. 1:53-75(1996).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (PTS), a major carbohydrate active -transport system, catalyzes
CC the phosphorylation of incoming sugar substrates concomitant with their
CC translocation across the cell membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00427, ECO:0000269|PubMed:15919996}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00427,
CC ECO:0000269|PubMed:15919996}.
CC -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC contains the specific substrate-binding site.
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DR EMBL; U14003; AAA97200.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77260.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78295.1; -; Genomic_DNA.
DR PIR; S56529; S56529.
DR RefSeq; NP_418724.1; NC_000913.3.
DR RefSeq; WP_000460843.1; NZ_SSUV01000012.1.
DR AlphaFoldDB; P39365; -.
DR BioGRID; 4262751; 8.
DR ComplexPortal; CPX-5990; sgcABC sugar permease enzyme II complex.
DR STRING; 511145.b4304; -.
DR TCDB; 4.A.5.1.3; the pts galactitol (gat) family.
DR PaxDb; P39365; -.
DR PRIDE; P39365; -.
DR EnsemblBacteria; AAC77260; AAC77260; b4304.
DR EnsemblBacteria; BAE78295; BAE78295; BAE78295.
DR GeneID; 946849; -.
DR KEGG; ecj:JW4266; -.
DR KEGG; eco:b4304; -.
DR PATRIC; fig|1411691.4.peg.2393; -.
DR EchoBASE; EB2444; -.
DR eggNOG; COG3775; Bacteria.
DR HOGENOM; CLU_040393_0_0_6; -.
DR InParanoid; P39365; -.
DR OMA; FGFMIWG; -.
DR PhylomeDB; P39365; -.
DR BioCyc; EcoCyc:SGCC-MON; -.
DR BioCyc; MetaCyc:SGCC-MON; -.
DR PRO; PR:P39365; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:1902495; C:transmembrane transporter complex; IC:ComplexPortal.
DR GO; GO:0015577; F:galactitol transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IC:ComplexPortal.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IC:ComplexPortal.
DR GO; GO:0015795; P:sorbitol transmembrane transport; IC:ComplexPortal.
DR InterPro; IPR013853; GatC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004703; PTS_sugar-sp_permease.
DR PANTHER; PTHR37324; PTHR37324; 1.
DR Pfam; PF03611; EIIC-GAT; 1.
DR PIRSF; PIRSF006304; GatC; 1.
DR TIGRFAMs; TIGR00827; EIIC-GAT; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Phosphotransferase system;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..437
FT /note="Putative permease IIC component"
FT /id="PRO_0000186691"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT DOMAIN 2..437
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
SQ SEQUENCE 437 AA; 46684 MW; 5FE8C034BD925F21 CRC64;
MFDYILSLGG TVFVPIIMIV IGLIFRIPWL QAIKAGVTVG IGFVGMGLVI VMAIDSLSPP
IKVMIERFGL ALHVFDVGAG PASGVGYATA IGAMIIPVIF LLNVAMLVTR LTKTMNVDIY
NYWHYAITGT VVQLMTGSLI YGVLGAICHA ALSLKMADWT AKRVQNIVGL EGISIPQGYG
SSSVPLFVLL DAIYEKIPFM KGRNIDAQEI QKRYGMVGDP VIIGVVLGLI FGLAAGEGFK
GCASLMITVA AIMVLFPRMI RLIVEGLLPI SDGARKFFQK YFKGREVYIG LDTAVTLGHP
TTIAVGLLLI PIMLILASIL PGNKVLPLAD LPVAPFFICM ATVIHRGDLV RTLISGVIVM
ITVLLIATQF APYFTEMALK GGFSFAGESA QISALSVGNM FGWSISELMS LGIIGVVVAV
GIVASVVLFL RKRELSE
