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SGCD_HUMAN
ID   SGCD_HUMAN              Reviewed;         289 AA.
AC   Q92629; A8K9S9; Q53XA5; Q99644;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 190.
DE   RecName: Full=Delta-sarcoglycan;
DE            Short=Delta-SG;
DE   AltName: Full=35 kDa dystrophin-associated glycoprotein;
DE            Short=35DAG;
GN   Name=SGCD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLN-96.
RC   TISSUE=Skeletal muscle;
RX   PubMed=8842738; DOI=10.1093/hmg/5.8.1179;
RA   Nigro V., Piluso G., Belsito A., Politano L., Puca A.A., Papparella S.,
RA   Rossi E., Viglietto G., Esposito M.G., Abbondanza C., Medici N.,
RA   Molinari A.M., Nigro G., Puca G.A.;
RT   "Identification of a novel sarcoglycan gene at 5q33 encoding a sarcolemmal
RT   35kDa glycoprotein.";
RL   Hum. Mol. Genet. 5:1179-1186(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC   TISSUE=Placenta;
RX   PubMed=8943294; DOI=10.1074/jbc.271.50.32321;
RA   Jung D., Duclos F., Apostol B., Straub V., Lee J.C., Allamand V.,
RA   Venzke D.P., Sunada Y., Moomaw C.R., Leveille C.J., Slaughter C.A.,
RA   Crawford T.O., McPherson J.D., Campbell K.P.;
RT   "Characterization of delta-sarcoglycan, a novel component of the oligomeric
RT   sarcoglycan complex involved in limb-girdle muscular dystrophy.";
RL   J. Biol. Chem. 271:32321-32329(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Retina;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [7]
RP   VARIANT LGMDR6 LYS-261.
RX   PubMed=9832045; DOI=10.1136/jmg.35.11.951;
RA   Moreira E.S., Vainzof M., Marie S.K., Nigro V., Zatz M., Passos-Bueno M.R.;
RT   "A first missense mutation in the delta sarcoglycan gene associated with a
RT   severe phenotype and frequency of limb-girdle muscular dystrophy type 2F
RT   (LGMD2F) in Brazilian sarcoglycanopathies.";
RL   J. Med. Genet. 35:951-953(1998).
RN   [8]
RP   VARIANT CMD1L ALA-150.
RX   PubMed=10974018; DOI=10.1172/jci9224;
RA   Tsubata S., Bowles K.R., Vatta M., Zintz C., Titus J., Muhonen L.,
RA   Bowles N.E., Towbin J.A.;
RT   "Mutations in the human delta-sarcoglycan gene in familial and sporadic
RT   dilated cardiomyopathy.";
RL   J. Clin. Invest. 106:655-662(2000).
RN   [9]
RP   INTERACTION WITH FLNC.
RX   PubMed=10629222; DOI=10.1083/jcb.148.1.115;
RA   Thompson T.G., Chan Y.-M., Hack A.A., Brosius M., Rajala M., Lidov H.G.W.,
RA   McNally E.M., Watkins S., Kunkel L.M.;
RT   "Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein.";
RL   J. Cell Biol. 148:115-126(2000).
CC   -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC       dystrophin-glycoprotein complex which forms a link between the F-actin
CC       cytoskeleton and the extracellular matrix.
CC   -!- SUBUNIT: Interacts with FLNC and DAG1. Cross-link to form 2 major
CC       subcomplexes: one consisting of SGCB, SGCD and SGCG and the other
CC       consisting of SGCB and SGCD. The association between SGCB and SGCG is
CC       particularly strong while SGCA is loosely associated with the other
CC       sarcoglycans (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Single-pass type II
CC       membrane protein. Cytoplasm, cytoskeleton.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q92629-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92629-2; Sequence=VSP_039245;
CC       Name=3;
CC         IsoId=Q92629-3; Sequence=VSP_039245, VSP_039246, VSP_039247;
CC   -!- TISSUE SPECIFICITY: Most strongly expressed in skeletal and cardiac
CC       muscle. Also detected in smooth muscle. Weak expression in brain and
CC       lung.
CC   -!- PTM: Glycosylated.
CC   -!- PTM: Disulfide bonds are present. {ECO:0000250}.
CC   -!- DISEASE: Muscular dystrophy, limb-girdle, autosomal recessive 6
CC       (LGMDR6) [MIM:601287]: An autosomal recessive degenerative myopathy
CC       initially affecting the proximal limb girdle musculature. Muscle from
CC       patients shows a complete loss of delta-sarcoglycan as well as of the
CC       others components of the sarcoglycan complex.
CC       {ECO:0000269|PubMed:9832045}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Cardiomyopathy, dilated 1L (CMD1L) [MIM:606685]: A disorder
CC       characterized by ventricular dilation and impaired systolic function,
CC       resulting in congestive heart failure and arrhythmia. Patients are at
CC       risk of premature death. {ECO:0000269|PubMed:10974018}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Leiden Muscular Dystrophy pages; Note=SGCD mutations
CC       in LGMD2F/CMD1L;
CC       URL="https://www.dmd.nl/sgcd_home.html";
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DR   EMBL; X95191; CAA64490.1; -; mRNA.
DR   EMBL; U58331; AAC50921.1; -; mRNA.
DR   EMBL; AK292794; BAF85483.1; -; mRNA.
DR   EMBL; BX537948; CAD97916.1; -; mRNA.
DR   EMBL; BC020740; AAH20740.1; -; mRNA.
DR   CCDS; CCDS47325.1; -. [Q92629-2]
DR   CCDS; CCDS47326.1; -. [Q92629-3]
DR   CCDS; CCDS47327.1; -. [Q92629-1]
DR   RefSeq; NP_000328.2; NM_000337.5. [Q92629-2]
DR   RefSeq; NP_001121681.1; NM_001128209.1. [Q92629-1]
DR   RefSeq; NP_758447.1; NM_172244.2. [Q92629-3]
DR   RefSeq; XP_005266023.1; XM_005265966.4. [Q92629-2]
DR   RefSeq; XP_011532923.1; XM_011534621.2. [Q92629-1]
DR   RefSeq; XP_016865212.1; XM_017009723.1. [Q92629-2]
DR   RefSeq; XP_016865213.1; XM_017009724.1. [Q92629-2]
DR   AlphaFoldDB; Q92629; -.
DR   BioGRID; 112342; 65.
DR   CORUM; Q92629; -.
DR   IntAct; Q92629; 13.
DR   MINT; Q92629; -.
DR   STRING; 9606.ENSP00000338343; -.
DR   GlyGen; Q92629; 3 sites.
DR   iPTMnet; Q92629; -.
DR   PhosphoSitePlus; Q92629; -.
DR   BioMuta; SGCD; -.
DR   DMDM; 212276471; -.
DR   jPOST; Q92629; -.
DR   MassIVE; Q92629; -.
DR   MaxQB; Q92629; -.
DR   PaxDb; Q92629; -.
DR   PeptideAtlas; Q92629; -.
DR   PRIDE; Q92629; -.
DR   ProteomicsDB; 75384; -. [Q92629-1]
DR   ProteomicsDB; 75385; -. [Q92629-2]
DR   ProteomicsDB; 75386; -. [Q92629-3]
DR   Antibodypedia; 8150; 287 antibodies from 34 providers.
DR   DNASU; 6444; -.
DR   Ensembl; ENST00000337851.9; ENSP00000338343.4; ENSG00000170624.14. [Q92629-2]
DR   Ensembl; ENST00000435422.7; ENSP00000403003.2; ENSG00000170624.14. [Q92629-1]
DR   Ensembl; ENST00000517913.5; ENSP00000429378.1; ENSG00000170624.14. [Q92629-3]
DR   GeneID; 6444; -.
DR   KEGG; hsa:6444; -.
DR   MANE-Select; ENST00000337851.9; ENSP00000338343.4; NM_000337.6; NP_000328.2. [Q92629-2]
DR   UCSC; uc003lwc.5; human. [Q92629-1]
DR   CTD; 6444; -.
DR   DisGeNET; 6444; -.
DR   GeneCards; SGCD; -.
DR   GeneReviews; SGCD; -.
DR   HGNC; HGNC:10807; SGCD.
DR   HPA; ENSG00000170624; Tissue enhanced (heart muscle, skeletal muscle, tongue).
DR   MalaCards; SGCD; -.
DR   MIM; 601287; phenotype.
DR   MIM; 601411; gene.
DR   MIM; 606685; phenotype.
DR   neXtProt; NX_Q92629; -.
DR   OpenTargets; ENSG00000170624; -.
DR   Orphanet; 219; Delta-sarcoglycan-related limb-girdle muscular dystrophy R6.
DR   Orphanet; 154; Familial isolated dilated cardiomyopathy.
DR   PharmGKB; PA35718; -.
DR   VEuPathDB; HostDB:ENSG00000170624; -.
DR   eggNOG; KOG3950; Eukaryota.
DR   GeneTree; ENSGT00940000158509; -.
DR   HOGENOM; CLU_043450_0_0_1; -.
DR   InParanoid; Q92629; -.
DR   OMA; XPKAVEA; -.
DR   OrthoDB; 1407024at2759; -.
DR   PhylomeDB; Q92629; -.
DR   TreeFam; TF313538; -.
DR   PathwayCommons; Q92629; -.
DR   SignaLink; Q92629; -.
DR   SIGNOR; Q92629; -.
DR   BioGRID-ORCS; 6444; 17 hits in 1070 CRISPR screens.
DR   ChiTaRS; SGCD; human.
DR   GeneWiki; Delta-sarcoglycan; -.
DR   GeneWiki; SGCD; -.
DR   GenomeRNAi; 6444; -.
DR   Pharos; Q92629; Tbio.
DR   PRO; PR:Q92629; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q92629; protein.
DR   Bgee; ENSG00000170624; Expressed in left ventricle myocardium and 179 other tissues.
DR   ExpressionAtlas; Q92629; baseline and differential.
DR   Genevisible; Q92629; HS.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR   GO; GO:0016012; C:sarcoglycan complex; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0086003; P:cardiac muscle cell contraction; IEA:Ensembl.
DR   GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR   GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central.
DR   GO; GO:0060977; P:coronary vasculature morphogenesis; IEA:Ensembl.
DR   GO; GO:0060047; P:heart contraction; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; TAS:ProtInc.
DR   GO; GO:0031503; P:protein-containing complex localization; IEA:Ensembl.
DR   InterPro; IPR006875; Sarcoglycan.
DR   InterPro; IPR039972; Sarcoglycan_gamma/delta/zeta.
DR   InterPro; IPR027661; SGCD.
DR   PANTHER; PTHR12939; PTHR12939; 1.
DR   PANTHER; PTHR12939:SF6; PTHR12939:SF6; 1.
DR   Pfam; PF04790; Sarcoglycan_1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cardiomyopathy; Cell membrane; Cytoplasm;
KW   Cytoskeleton; Disease variant; Disulfide bond; Glycoprotein;
KW   Limb-girdle muscular dystrophy; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..289
FT                   /note="Delta-sarcoglycan"
FT                   /id="PRO_0000175245"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..289
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        263..288
FT                   /evidence="ECO:0000255"
FT   DISULFID        265..281
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MM (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8842738,
FT                   ECO:0000303|PubMed:8943294"
FT                   /id="VSP_039245"
FT   VAR_SEQ         233..255
FT                   /note="IKLDAAKIRLPRLPHGSYTPTGT -> VRDEKDRSSKSYSFNRPTLPITG
FT                   (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:8943294"
FT                   /id="VSP_039246"
FT   VAR_SEQ         256..289
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:8943294"
FT                   /id="VSP_039247"
FT   VARIANT         96
FT                   /note="R -> Q (in dbSNP:rs45559835)"
FT                   /evidence="ECO:0000269|PubMed:8842738"
FT                   /id="VAR_010429"
FT   VARIANT         150
FT                   /note="S -> A (in CMD1L; dbSNP:rs121909298)"
FT                   /evidence="ECO:0000269|PubMed:10974018"
FT                   /id="VAR_013181"
FT   VARIANT         261
FT                   /note="E -> K (in LGMDR6; dbSNP:rs121909297)"
FT                   /evidence="ECO:0000269|PubMed:9832045"
FT                   /id="VAR_010396"
SQ   SEQUENCE   289 AA;  32071 MW;  EB775E2427D260B7 CRC64;
     MPQEQYTHHR STMPGSVGPQ VYKVGIYGWR KRCLYFFVLL LMILILVNLA MTIWILKVMN
     FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIQSRPGNA LYFKSARNVT VNILNDQTKV
     LTQLITGPKA VEAYGKKFEV KTVSGKLLFS ADNNEVVVGA ERLRVLGAEG TVFPKSIETP
     NVRADPFKEL RLESPTRSLV MEAPKGVEIN AEAGNMEATC RTELRLESKD GEIKLDAAKI
     RLPRLPHGSY TPTGTRQKVF EICVCANGRL FLSQAGAGST CQINTSVCL
 
 
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