SGCE_BOVIN
ID SGCE_BOVIN Reviewed; 437 AA.
AC Q29S03;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 3.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Epsilon-sarcoglycan;
DE Short=Epsilon-SG;
GN Name=SGCE;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC dystrophin-glycoprotein complex which forms a link between the F-actin
CC cytoskeleton and the extracellular matrix. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Golgi apparatus
CC {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sarcoglycan alpha/epsilon family.
CC {ECO:0000305}.
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DR EMBL; BC113276; AAI13277.1; -; mRNA.
DR RefSeq; NP_001068613.1; NM_001075145.1.
DR AlphaFoldDB; Q29S03; -.
DR STRING; 9913.ENSBTAP00000028355; -.
DR PaxDb; Q29S03; -.
DR PRIDE; Q29S03; -.
DR GeneID; 407209; -.
DR KEGG; bta:407209; -.
DR CTD; 8910; -.
DR eggNOG; KOG4482; Eukaryota.
DR InParanoid; Q29S03; -.
DR OrthoDB; 534519at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0016012; C:sarcoglycan complex; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR InterPro; IPR006644; Cadg.
DR InterPro; IPR008908; Sarcoglycan_alpha/epsilon.
DR InterPro; IPR030775; SGCE.
DR PANTHER; PTHR10132; PTHR10132; 1.
DR PANTHER; PTHR10132:SF17; PTHR10132:SF17; 1.
DR Pfam; PF05510; Sarcoglycan_2; 1.
DR SMART; SM00736; CADG; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Glycoprotein;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Ubl conjugation.
FT CHAIN 1..437
FT /note="Epsilon-sarcoglycan"
FT /evidence="ECO:0000250"
FT /id="PRO_0000285122"
FT TOPO_DOM 1..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..437
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 418..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 49889 MW; 081DDBE0A37CA557 CRC64;
MQLPWWWELG DPCAWTGQGR GTRRMSPATT GTFLLTVYTI FSKVHSDRNV YPSAGVLFVH
VLEREYFKGE FPPYPKPGEI SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA
ENVGKPTVIE ITAYNRRTFE TARHNLIINI MSAEDFPLPY QAEFFIKNMN VEEMLASEVL
GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPINDMKE GVYVMVGADV PFSSCLREVE
NPQNQLRCSQ EMEPVITCDK KFRTQFYIDW CKISLVDKTK QVSTYQEVIR GEGILPDGGE
YKPPSDSLKS RDYYTDFLVT LAVPSAVALV LFLILAYIMC CRREGVEKRN MQTPDIQLVH
HSAIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEIIPP LHTDNYESTN MPLMQTQQNL
PHQTQIPQQQ TTGKWYS
