ID   SGCE_MACFA              Reviewed;         437 AA.
AC   Q4R5B1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Epsilon-sarcoglycan {ECO:0000250|UniProtKB:O43556};
DE            Short=Epsilon-SG {ECO:0000250|UniProtKB:O43556};
GN   Name=SGCE {ECO:0000250|UniProtKB:O43556}; ORFNames=QtrA-13407;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAE01714.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC       dystrophin-glycoprotein complex which forms a link between the F-actin
CC       cytoskeleton and the extracellular matrix.
CC       {ECO:0000250|UniProtKB:O43556}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC       pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P82350}. Cell projection, dendrite
CC       {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sarcoglycan alpha/epsilon family.
CC       {ECO:0000255}.
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DR   EMBL; AB169633; BAE01714.1; -; mRNA.
DR   RefSeq; XP_005550257.1; XM_005550200.2.
DR   AlphaFoldDB; Q4R5B1; -.
DR   STRING; 9541.XP_005550251.1; -.
DR   GeneID; 101865326; -.
DR   KEGG; mcf:101865326; -.
DR   CTD; 8910; -.
DR   VEuPathDB; HostDB:ENSMFAG00000000448; -.
DR   eggNOG; KOG4482; Eukaryota.
DR   Proteomes; UP000233100; Chromosome 3.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006644; Cadg.
DR   InterPro; IPR008908; Sarcoglycan_alpha/epsilon.
DR   InterPro; IPR030775; SGCE.
DR   PANTHER; PTHR10132; PTHR10132; 1.
DR   PANTHER; PTHR10132:SF17; PTHR10132:SF17; 1.
DR   Pfam; PF05510; Sarcoglycan_2; 1.
DR   SMART; SM00736; CADG; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Glycoprotein;
KW   Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Ubl conjugation.
FT   CHAIN           1..437
FT                   /note="Epsilon-sarcoglycan"
FT                   /id="PRO_0000378622"
FT   TOPO_DOM        1..317
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:O43556, ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..437
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:O43556, ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   437 AA;  49865 MW;  529DED49311CDFAE CRC64;
     MQLPRWWELG DPCAWTGQGR GTRRMSPATT GTFLLTVYTI FSKVHSDRNV YPSAGVLFVH
     VLEREYFKGE FPPYPKPGEI SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA
     ENVGKPTIIE ITAYNRRTFE TARHNLIINI MSAEDFPLPY QAEFFIKNMN VEEMLASEVL
     GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPINDLKE GVYVMVGADV PFSSCLREVE
     NPQNQLRCSQ EMEPVITCDK KFRTQFYIDW CKISLVDKTK QVSTYQEVIR GEGILPDGGE
     YKPPSDSLKS RDYYTDFLIT LAVPSAVALV LFLILAYIMC CRREGVEKRN MQTPDIQLVH
     HSAIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEIIPP LHTDNYDSTN MPLMQTQQNL
     PHQTQIPQQQ TTGKWYP