SGCE_RAT
ID SGCE_RAT Reviewed; 437 AA.
AC Q6YAT4;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Epsilon-sarcoglycan {ECO:0000312|EMBL:AAO37579.1};
DE Short=Epsilon-SG {ECO:0000250|UniProtKB:O43556};
GN Name=Sgce {ECO:0000312|EMBL:AAO37579.1, ECO:0000312|RGD:1303201};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO37579.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAO37579.1};
RX PubMed=14625080; DOI=10.1016/j.molbrainres.2003.09.004;
RA Xiao J., LeDoux M.S.;
RT "Cloning, developmental regulation and neural localization of rat epsilon-
RT sarcoglycan.";
RL Brain Res. Mol. Brain Res. 119:132-143(2003).
RN [2] {ECO:0000312|EMBL:AAH89947.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAH89947.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC dystrophin-glycoprotein complex which forms a link between the F-actin
CC cytoskeleton and the extracellular matrix.
CC {ECO:0000250|UniProtKB:O43556}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:P82350}. Cell projection, dendrite
CC {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In both neural tissues including cerebellar cortex,
CC striatum, cerebral cortex, thalamus and hippocampus, and non-neural
CC tissues including quadriceps muscle, liver, kidney, spleen, lung,
CC testis and heart. Widely distributed in the brain, with a robust signal
CC obtained from regions with dense neuronal packing such as the pyramidal
CC cell layer of the hippocampus, cerebellar molecular layer, and cerebral
CC cortex. Levels are highest in kidney, moderate in brain and lung, and
CC low in skeletal muscle, liver, spleen and testis.
CC {ECO:0000269|PubMed:14625080}.
CC -!- DEVELOPMENTAL STAGE: Expressed at embryonic day 20, postnatal days 1,
CC 7, 14, 36, six months and one and a half years. Highest level at E20.
CC In muscle, expression is over 10 times higher at E20 and during the
CC early postnatal period than in adults. In adults, expression levels are
CC several-fold higher in brain, particularly in the cerebellar cortex,
CC than in muscle. {ECO:0000269|PubMed:14625080}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sarcoglycan alpha/epsilon family.
CC {ECO:0000255}.
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DR EMBL; AY164274; AAO37579.1; -; mRNA.
DR EMBL; BC089947; AAH89947.1; -; mRNA.
DR RefSeq; NP_001002023.1; NM_001002023.2.
DR AlphaFoldDB; Q6YAT4; -.
DR SMR; Q6YAT4; -.
DR STRING; 10116.ENSRNOP00000064432; -.
DR GlyGen; Q6YAT4; 1 site.
DR PaxDb; Q6YAT4; -.
DR PRIDE; Q6YAT4; -.
DR GeneID; 432360; -.
DR KEGG; rno:432360; -.
DR CTD; 8910; -.
DR RGD; 1303201; Sgce.
DR eggNOG; KOG4482; Eukaryota.
DR InParanoid; Q6YAT4; -.
DR OrthoDB; 534519at2759; -.
DR PhylomeDB; Q6YAT4; -.
DR PRO; PR:Q6YAT4; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0032590; C:dendrite membrane; ISS:UniProtKB.
DR GO; GO:0016010; C:dystrophin-associated glycoprotein complex; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0016012; C:sarcoglycan complex; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0007420; P:brain development; IEP:RGD.
DR GO; GO:0001822; P:kidney development; IEP:RGD.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEP:RGD.
DR InterPro; IPR006644; Cadg.
DR InterPro; IPR008908; Sarcoglycan_alpha/epsilon.
DR InterPro; IPR030775; SGCE.
DR PANTHER; PTHR10132; PTHR10132; 1.
DR PANTHER; PTHR10132:SF17; PTHR10132:SF17; 1.
DR Pfam; PF05510; Sarcoglycan_2; 1.
DR SMART; SM00736; CADG; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Glycoprotein;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Ubl conjugation.
FT CHAIN 1..437
FT /note="Epsilon-sarcoglycan"
FT /id="PRO_0000378624"
FT TOPO_DOM 1..317
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:O43556, ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 339..437
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:O43556, ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 49840 MW; 04D6F1F5469E7112 CRC64;
MLLFWWWELG DPCAWTGKGR GTLKMSPATT GTFLLTVYTL FSKVHSDRNV YPSAGVLFVH
VLEREYFKGE FPPYPKPGEV SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA
ENVGKPTIIE ITAYNRRTFE TARHNLIINI MSAEEFPLPY QAEFFIKNMN VEEMLASEVL
GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPIKDMKE GVYVMVGADV AFSSCLREVE
NPQNQLRCSQ EMEPVITCDK KFRTQFYIDW CKISLVDKTK QVSTYQEVVR GEGILPDGGE
YKPPSDSLKS RDYYTDFLVT LAVPSAVALV LFLILAYIMC CRREGVEKRN MQTPDIQLVH
HSSIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEIIPP MHTDNYDSTN MPLMQTQPNL
PHQTQIPQQQ TTGKWYP
