ID   SGCG_BOVIN              Reviewed;         291 AA.
AC   Q0VCU7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Gamma-sarcoglycan;
DE            Short=Gamma-SG;
GN   Name=SGCG;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC       dystrophin-glycoprotein complex which forms a link between the F-actin
CC       cytoskeleton and the extracellular matrix. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the syntrophin SNTA1. Cross-link to form 2
CC       major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other
CC       consisting of SGCB and SGCD. The association between SGCB and SGCG is
CC       particularly strong while SGCA is loosely associated with the other
CC       sarcoglycans. Interacts with FLNC (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- PTM: Disulfide bonds are present. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC       {ECO:0000305}.
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DR   EMBL; BC119990; AAI19991.1; -; mRNA.
DR   RefSeq; NP_001068712.1; NM_001075244.1.
DR   RefSeq; XP_010809098.1; XM_010810796.1.
DR   AlphaFoldDB; Q0VCU7; -.
DR   STRING; 9913.ENSBTAP00000002431; -.
DR   PaxDb; Q0VCU7; -.
DR   Ensembl; ENSBTAT00000002431; ENSBTAP00000002431; ENSBTAG00000001865.
DR   GeneID; 506155; -.
DR   KEGG; bta:506155; -.
DR   CTD; 6445; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001865; -.
DR   VGNC; VGNC:34539; SGCG.
DR   eggNOG; KOG3950; Eukaryota.
DR   GeneTree; ENSGT00940000159187; -.
DR   HOGENOM; CLU_043450_0_0_1; -.
DR   InParanoid; Q0VCU7; -.
DR   OMA; SHNDNML; -.
DR   OrthoDB; 1407024at2759; -.
DR   TreeFam; TF313538; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000001865; Expressed in laryngeal cartilage and 66 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016012; C:sarcoglycan complex; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central.
DR   GO; GO:0060047; P:heart contraction; IBA:GO_Central.
DR   InterPro; IPR006875; Sarcoglycan.
DR   InterPro; IPR039972; Sarcoglycan_gamma/delta/zeta.
DR   InterPro; IPR027660; SGCG.
DR   PANTHER; PTHR12939; PTHR12939; 1.
DR   PANTHER; PTHR12939:SF4; PTHR12939:SF4; 1.
DR   Pfam; PF04790; Sarcoglycan_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..291
FT                   /note="Gamma-sarcoglycan"
FT                   /id="PRO_0000285123"
FT   TRANSMEM        38..58
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..291
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        265..290
FT                   /evidence="ECO:0000255"
FT   DISULFID        267..283
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  32179 MW;  1DA382DE5132CEDD CRC64;
     MVREQYTTIT EGTHIERPEN QAVYKIGIYG WRKRCLYLFV LLLLIVLLVN FALTIWILRV
     MWFSPVGMGH LHVTADGLHL EGESEFLFPL YVKEIRSRVD SSLLLQSTQN VTMNARNTEG
     EVTGRLKVGP QMVEVQSQQF QIHSKDGKPL FTVDEEKVMV GTDKLRVTGP EGALFEHSVE
     TPLVRPDPPQ DLRLESPTRS LSMDAPKGIH IQAPAGKIEA LTQMDIVLQS SDGTVVLDAE
     TVCLPELALG SQGPAGSSQG LYEVCVCPDG KLYLSVAGMG TTCHEHSHLC L