SGCG_MOUSE
ID SGCG_MOUSE Reviewed; 291 AA.
AC P82348;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Gamma-sarcoglycan;
DE Short=Gamma-SG;
DE AltName: Full=35 kDa dystrophin-associated glycoprotein;
DE Short=35DAG;
GN Name=Sgcg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=10448073; DOI=10.1006/bbrc.1999.1163;
RA Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.;
RT "Developmental expression of sarcoglycan gene products in cultured
RT myocytes.";
RL Biochem. Biophys. Res. Commun. 262:88-93(1999).
RN [2]
RP INTERACTION WITH SNTA1.
RX PubMed=7547961; DOI=10.1021/bi00038a014;
RA Madhavan R., Jarrett H.W.;
RT "Interactions between dystrophin glycoprotein complex proteins.";
RL Biochemistry 34:12204-12209(1995).
RN [3]
RP SUBCELLULAR LOCATION, SUBUNIT, AND DISULFIDE BONDS.
RX PubMed=9864373; DOI=10.1083/jcb.143.7.2033;
RA Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.;
RT "Molecular organization of sarcoglycan complex in mouse myotubes in
RT culture.";
RL J. Cell Biol. 143:2033-2044(1998).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the sarcoglycan complex, a subcomplex of the
CC dystrophin-glycoprotein complex which forms a link between the F-actin
CC cytoskeleton and the extracellular matrix.
CC -!- SUBUNIT: Interacts with the syntrophin SNTA1 and FLNC. Cross-link to
CC form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and
CC the other consisting of SGCB and SGCD. The association between SGCB and
CC SGCG is particularly strong while SGCA is loosely associated with the
CC other sarcoglycans. {ECO:0000269|PubMed:7547961,
CC ECO:0000269|PubMed:9864373}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000269|PubMed:9864373}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:9864373}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:9864373}.
CC -!- TISSUE SPECIFICITY: Most strongly expressed in skeletal and heart
CC muscle. Also detected in proliferating myoblasts.
CC -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC {ECO:0000305}.
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DR EMBL; AB024922; BAA83493.1; -; mRNA.
DR CCDS; CCDS27181.1; -.
DR RefSeq; NP_036022.1; NM_011892.3.
DR RefSeq; XP_006519075.1; XM_006519012.2.
DR AlphaFoldDB; P82348; -.
DR BioGRID; 204866; 3.
DR CORUM; P82348; -.
DR STRING; 10090.ENSMUSP00000077106; -.
DR GlyGen; P82348; 1 site.
DR iPTMnet; P82348; -.
DR PhosphoSitePlus; P82348; -.
DR EPD; P82348; -.
DR PaxDb; P82348; -.
DR PRIDE; P82348; -.
DR ProteomicsDB; 256978; -.
DR Antibodypedia; 2309; 152 antibodies from 29 providers.
DR DNASU; 24053; -.
DR Ensembl; ENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296.
DR Ensembl; ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296.
DR GeneID; 24053; -.
DR KEGG; mmu:24053; -.
DR UCSC; uc007ufs.1; mouse.
DR CTD; 6445; -.
DR MGI; MGI:1346524; Sgcg.
DR VEuPathDB; HostDB:ENSMUSG00000035296; -.
DR eggNOG; KOG3950; Eukaryota.
DR GeneTree; ENSGT00940000159187; -.
DR HOGENOM; CLU_043450_0_0_1; -.
DR InParanoid; P82348; -.
DR OMA; SHNDNML; -.
DR OrthoDB; 1407024at2759; -.
DR PhylomeDB; P82348; -.
DR TreeFam; TF313538; -.
DR BioGRID-ORCS; 24053; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Sgcg; mouse.
DR PRO; PR:P82348; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P82348; protein.
DR Bgee; ENSMUSG00000035296; Expressed in temporalis muscle and 108 other tissues.
DR ExpressionAtlas; P82348; baseline and differential.
DR Genevisible; P82348; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016011; C:dystroglycan complex; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0016012; C:sarcoglycan complex; IDA:MGI.
DR GO; GO:0042383; C:sarcolemma; IDA:MGI.
DR GO; GO:0048738; P:cardiac muscle tissue development; IBA:GO_Central.
DR GO; GO:0060047; P:heart contraction; IBA:GO_Central.
DR GO; GO:0061024; P:membrane organization; TAS:MGI.
DR InterPro; IPR006875; Sarcoglycan.
DR InterPro; IPR039972; Sarcoglycan_gamma/delta/zeta.
DR InterPro; IPR027660; SGCG.
DR PANTHER; PTHR12939; PTHR12939; 1.
DR PANTHER; PTHR12939:SF4; PTHR12939:SF4; 1.
DR Pfam; PF04790; Sarcoglycan_1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..291
FT /note="Gamma-sarcoglycan"
FT /id="PRO_0000175250"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 265..290
FT /evidence="ECO:0000255"
FT DISULFID 267..283
FT /evidence="ECO:0000255"
SQ SEQUENCE 291 AA; 32082 MW; D61C53F08F241140 CRC64;
MVREQYTTVT EGTHIERPEN QHIYKIGIYG WRKRCLYLFV LLLLAILVVN LALTIWILKV
MWFSPIGMGH LHVTADGLRL EGESEFLFPL YAKEIRSRVD SSLLLQSTQN VTVSARNSEG
EVTGRVKVGA QMVEVQSQHF QINSEDGKPL FSAEEQDVVV GTGRLRVTGP EGALFEHSVE
TPLVRADPFQ DLRLESPTRS LSMDAPRGVH VKANAGKLEA LSQMDIILQS SEGVLVLDAE
TVGLTKLKQG TQGPAGSSNG FYEICACPDG KLYLSMAGEV TTCEEHSHVC L
