ID   SGCX_SALTI              Reviewed;         372 AA.
AC   P58536;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative aminopeptidase SgcX;
DE            EC=3.4.11.-;
GN   Name=sgcX; OrderedLocusNames=STY1452, t1521;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M42 family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD01713.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69156.1; -; Genomic_DNA.
DR   RefSeq; NP_455885.1; NC_003198.1.
DR   RefSeq; WP_000144622.1; NZ_WSUR01000020.1.
DR   AlphaFoldDB; P58536; -.
DR   SMR; P58536; -.
DR   STRING; 220341.16502563; -.
DR   MEROPS; M42.A01; -.
DR   EnsemblBacteria; AAO69156; AAO69156; t1521.
DR   KEGG; stt:t1521; -.
DR   KEGG; sty:STY1452; -.
DR   PATRIC; fig|220341.7.peg.1462; -.
DR   eggNOG; COG1363; Bacteria.
DR   HOGENOM; CLU_047249_0_1_6; -.
DR   OMA; FGWPAIH; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.40; -; 1.
DR   InterPro; IPR008007; Peptidase_M42.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   Pfam; PF05343; Peptidase_M42; 1.
DR   PIRSF; PIRSF001123; PepA_GA; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase; Hydrolase; Metal-binding; Metalloprotease; Protease.
FT   CHAIN           1..372
FT                   /note="Putative aminopeptidase SgcX"
FT                   /id="PRO_0000071657"
FT   ACT_SITE        212
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         67
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         180
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         180
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         213
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         235
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         329
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   372 AA;  40341 MW;  17E7375C3E02707F CRC64;
     MTFSVQETLF SLLRLNGISG HESSIANVMQ HAFEQQAKDV WRDRLGNVVA RYGSDKSDAL
     RLMIFAHMDE VGFMVRKIEP SGFLRFERVG GPAQITMPGS IVTLAGCSGD IMGCIGIKAY
     HFAKGDERTQ PPALDKLWID IGAKDKADAE RMGIQVGTPV TLYNPPHCLG NDLVCSKALD
     DRLGCTALLG VAEALASTPL DIAVFLVASV QEEFNIRGIV PVLRRVRPDL AIGIDITPSC
     DTPDLQDYSD VRVNHGVGIT CLNYHGRGTL AGLITPPRLL RMLETTAHEN NIPVQREVAP
     GVITETGYIQ VELDGIPCAS LSIPCRYTHS PAEVASLRDL ADCIRLLTAL ANMSPEQFPI
     DPETGATQEA RP