SGLT_VIBPH
ID SGLT_VIBPH Reviewed; 543 AA.
AC P96169;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Sodium/glucose cotransporter;
DE AltName: Full=Na(+)/glucose symporter;
GN Name=sglT;
OS Vibrio parahaemolyticus.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=670;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AQ3334;
RX PubMed=8652595; DOI=10.1016/0005-2736(96)00025-9;
RA Sarker R.I., Okabe Y., Tsuda M., Tsuchiya T.;
RT "Sequence of a Na+/glucose symporter gene and its flanking regions of
RT Vibrio parahaemolyticus.";
RL Biochim. Biophys. Acta 1281:1-4(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10835424; DOI=10.1074/jbc.m003127200;
RA Turk E., Kim O., Le Coutre J., Whitelegge J.P., Eskandari S., Lam J.T.,
RA Kreman M., Zampighi G., Faull K.F., Wright E.M.;
RT "Molecular characterization of Vibrio parahaemolyticus vSGLT: a model for
RT sodium-coupled sugar cotransporters.";
RL J. Biol. Chem. 275:25711-25716(2000).
RN [3]
RP MASS SPECTROMETRY OF FORMYLATED FORM, AND SEQUENCE REVISION TO N-TERMINUS.
RX PubMed=10757971; DOI=10.1021/bi000150m;
RA le Coutre J., Whitelegge J.P., Gross A., Turk E., Wright E.M., Kaback H.R.,
RA Faull K.F.;
RT "Proteomics on full-length membrane proteins using mass spectrometry.";
RL Biochemistry 39:4237-4242(2000).
CC -!- FUNCTION: Actively transports glucose into cells by Na(+) cotransport.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MASS SPECTROMETRY: Mass=60680; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:10757971};
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; D78137; BAA11215.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AF255301; AAF80602.1; -; Genomic_DNA.
DR RefSeq; WP_029825056.1; NZ_VTGJ01000015.1.
DR PDB; 2XQ2; X-ray; 2.73 A; A=1-543, B=51-543.
DR PDB; 3DH4; X-ray; 2.70 A; A/B/C/D=47-543.
DR PDBsum; 2XQ2; -.
DR PDBsum; 3DH4; -.
DR AlphaFoldDB; P96169; -.
DR SMR; P96169; -.
DR TCDB; 2.A.21.3.2; the solute:sodium symporter (sss) family.
DR PATRIC; fig|670.406.peg.3043; -.
DR EvolutionaryTrace; P96169; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Ion transport; Membrane; Sodium;
KW Sodium transport; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..543
FT /note="Sodium/glucose cotransporter"
FT /id="PRO_0000105405"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 10..28
FT /evidence="ECO:0007829|PDB:2XQ2"
FT HELIX 53..64
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 67..70
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 72..79
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 82..84
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 85..101
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 103..108
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 114..121
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 124..140
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 142..157
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 162..175
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 188..212
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 213..215
FT /evidence="ECO:0007829|PDB:2XQ2"
FT HELIX 217..227
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 229..232
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 238..241
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 242..245
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 250..253
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 256..263
FT /evidence="ECO:0007829|PDB:3DH4"
FT TURN 264..267
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 269..275
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 276..278
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 280..296
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 302..313
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 315..321
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 332..334
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 335..337
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 338..343
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 350..380
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 381..386
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 394..413
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 414..419
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 423..431
FT /evidence="ECO:0007829|PDB:3DH4"
FT TURN 432..434
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 435..447
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 453..471
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 473..475
FT /evidence="ECO:0007829|PDB:3DH4"
FT HELIX 479..499
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 503..506
FT /evidence="ECO:0007829|PDB:3DH4"
FT STRAND 515..518
FT /evidence="ECO:0007829|PDB:2XQ2"
FT HELIX 524..543
FT /evidence="ECO:0007829|PDB:3DH4"
SQ SEQUENCE 543 AA; 58875 MW; 61BE3F7E380BC32C CRC64;
MSNIEHGLSF IDIMVFAIYV AIIIGVGLWV SRDKKGTQKS TEDYFLAGKS LPWWAVGASL
IAANISAEQF IGMSGSGYSI GLAIASYEWM SAITLIIVGK YFLPIFIEKG IYTIPEFVEK
RFNKKLKTIL AVFWISLYIF VNLTSVLYLG GLALETILGI PLMYSILGLA LFALVYSIYG
GLSAVVWTDV IQVFFLVLGG FMTTYMAVSF IGGTDGWFAG VSKMVDAAPG HFEMILDQSN
PQYMNLPGIA VLIGGLWVAN LYYWGFNQYI IQRTLAAKSV SEAQKGIVFA AFLKLIVPFL
VVLPGIAAYV ITSDPQLMAS LGDIAATNLP SAANADKAYP WLTQFLPVGV KGVVFAALAA
AIVSSLASML NSTATIFTMD IYKEYISPDS GDHKLVNVGR TAAVVALIIA CLIAPMLGGI
GQAFQYIQEY TGLVSPGILA VFLLGLFWKK TTSKGAIIGV VASIPFALFL KFMPLSMPFM
DQMLYTLLFT MVVIAFTSLS TSINDDDPKG ISVTSSMFVT DRSFNIAAYG IMIVLAVLYT
LFW
