SGMR1_CHICK
ID SGMR1_CHICK Reviewed; 222 AA.
AC Q5ZL84;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Sigma non-opioid intracellular receptor 1;
DE AltName: Full=Sigma 1-type opioid receptor;
DE Short=Sigma1-receptor;
DE Short=Sigma1R;
GN Name=SIGMAR1; Synonyms=OPRS1; ORFNames=RCJMB04_7e2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: May function in lipid transport from the endoplasmic
CC reticulum and be involved in a wide array of cellular functions
CC probably through regulation of the biogenesis of lipid microdomains at
CC the plasma membrane. May regulate calcium efflux at the endoplasmic
CC reticulum (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer (By similarity). {ECO:0000250|UniProtKB:Q99720}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus outer membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus envelope
CC {ECO:0000250|UniProtKB:Q99720}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q99720}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q99720}. Membrane
CC {ECO:0000250|UniProtKB:Q99720}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q99720}. Note=During interphase, detected at the
CC inner and outer nuclear membrane and the endoplasmic reticulum.
CC Detected on cytoplasmic vesicles during mitosis (By similarity).
CC Targeted to lipid droplets, cholesterol and galactosylceramide-enriched
CC domains of the endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:O55242, ECO:0000250|UniProtKB:Q99720}.
CC -!- DOMAIN: The C-terminal helices form a flat, hydrophobic surface that is
CC probably tightly associated with the cytosolic surface of the
CC endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q99720}.
CC -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC 1 and Sigma-2) based on their different pharmacological profile.
CC {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
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DR EMBL; AJ719850; CAG31509.1; -; mRNA.
DR RefSeq; NP_001257486.3; NM_001270557.3.
DR AlphaFoldDB; Q5ZL84; -.
DR SMR; Q5ZL84; -.
DR STRING; 9031.ENSGALP00000042968; -.
DR Ensembl; ENSGALT00000046016; ENSGALP00000042968; ENSGALG00000028996.
DR GeneID; 100859748; -.
DR KEGG; gga:100859748; -.
DR CTD; 10280; -.
DR VEuPathDB; HostDB:geneid_100859748; -.
DR eggNOG; KOG4143; Eukaryota.
DR GeneTree; ENSGT00390000012082; -.
DR HOGENOM; CLU_085469_0_0_1; -.
DR InParanoid; Q5ZL84; -.
DR OMA; LWATTRI; -.
DR OrthoDB; 1285317at2759; -.
DR PhylomeDB; Q5ZL84; -.
DR PRO; PR:Q5ZL84; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000028996; Expressed in liver and 12 other tissues.
DR ExpressionAtlas; Q5ZL84; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; ISS:UniProtKB.
DR InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR PANTHER; PTHR10868; PTHR10868; 1.
DR Pfam; PF04622; ERG2_Sigma1R; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Lipid transport; Membrane;
KW Nucleus; Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..222
FT /note="Sigma non-opioid intracellular receptor 1"
FT /id="PRO_0000268657"
FT TOPO_DOM 1..7
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TRANSMEM 8..29
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TOPO_DOM 30..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT REGION 98..105
FT /note="Important for ligand-binding"
FT /evidence="ECO:0000250|UniProtKB:Q60492"
FT REGION 176..222
FT /note="C-terminal hydrophobic region"
FT /evidence="ECO:0000305"
FT SITE 125
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT SITE 171
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
SQ SEQUENCE 222 AA; 24602 MW; A0D182ABDE03754C CRC64;
MGVAGPWVLR VGLGLGAFAL LLQGLRGWLA CKRYEFQPAE IAELARHHAG LDHELAFSKI
IVELRKKHPG HILPDEDLQW VFVNAGGWMG SMCLLHASLT EYVLLFGTAI DTGGHSGRYW
AEIYDTIISG TFRQWKEGTT RSEIYYPGDT IVHQAGEATS VQWSAGTWMV EYGRGFVPST
LAFALADTLF STQDFITLFY TLRAYTKGLL LEASAFFSTL GC
