SGMR1_DANRE
ID SGMR1_DANRE Reviewed; 222 AA.
AC Q7ZWG9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Sigma non-opioid intracellular receptor 1;
DE AltName: Full=Sigma 1-type opioid receptor;
DE Short=Sigma1-receptor;
DE Short=Sigma1R;
GN Name=sigmar1; Synonyms=oprs1; ORFNames=zgc:56378;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function in lipid transport from the endoplasmic
CC reticulum and be involved in a wide array of cellular functions
CC probably through regulation of the biogenesis of lipid microdomains at
CC the plasma membrane. May regulate calcium efflux at the endoplasmic
CC reticulum (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer (By similarity). {ECO:0000250|UniProtKB:Q99720}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus outer membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus envelope
CC {ECO:0000250|UniProtKB:Q99720}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q99720}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q99720}. Membrane
CC {ECO:0000250|UniProtKB:Q99720}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q99720}. Note=During interphase, detected at the
CC inner and outer nuclear membrane and the endoplasmic reticulum.
CC Detected on cytoplasmic vesicles during mitosis (By similarity).
CC Targeted to lipid droplets, cholesterol and galactosylceramide-enriched
CC domains of the endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:O55242, ECO:0000250|UniProtKB:Q99720}.
CC -!- DOMAIN: The C-terminal helices form a flat, hydrophobic surface that is
CC probably tightly associated with the cytosolic surface of the
CC endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q99720}.
CC -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC 1 and Sigma-2) based on their different pharmacological profile.
CC {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
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DR EMBL; BC049416; AAH49416.1; -; mRNA.
DR RefSeq; NP_957271.1; NM_200977.1.
DR AlphaFoldDB; Q7ZWG9; -.
DR SMR; Q7ZWG9; -.
DR STRING; 7955.ENSDARP00000011354; -.
DR PaxDb; Q7ZWG9; -.
DR GeneID; 393952; -.
DR KEGG; dre:393952; -.
DR CTD; 10280; -.
DR ZFIN; ZDB-GENE-040426-1006; sigmar1.
DR eggNOG; KOG4143; Eukaryota.
DR InParanoid; Q7ZWG9; -.
DR OrthoDB; 1285317at2759; -.
DR PhylomeDB; Q7ZWG9; -.
DR PRO; PR:Q7ZWG9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0009611; P:response to wounding; IMP:ZFIN.
DR InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR PANTHER; PTHR10868; PTHR10868; 1.
DR Pfam; PF04622; ERG2_Sigma1R; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Lipid transport; Membrane;
KW Nucleus; Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..222
FT /note="Sigma non-opioid intracellular receptor 1"
FT /id="PRO_0000268658"
FT TOPO_DOM 1..6
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TOPO_DOM 30..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT REGION 97..104
FT /note="Important for ligand-binding"
FT /evidence="ECO:0000250|UniProtKB:Q60492"
FT REGION 175..222
FT /note="C-terminal hydrophobic region"
FT /evidence="ECO:0000305"
FT SITE 124
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT SITE 170
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
SQ SEQUENCE 222 AA; 24941 MW; 234A53B2D4A3F3B6 CRC64;
MSLIRTILKL VVVVGFLSLT VQFIRHWMAN KQYVFTKEEV AKLAKQYAGQ DHEQAFSKVV
VELRRRYPGH ILPDEDLQWV FVNAGGWMGS MCLLHASLTE YVLLFGTAVD TGGHSGRYWA
EISDTIISGT FRQWKEGTTK SETYYPGDTI VHSAGEATSV QWSSGTWMVE YGRGFIPSTL
GFALADTMFS TQDFLTLFYT ARVYVKGMIL EASTFLTESG VL
