ID   SGMR1_TARGR             Reviewed;         223 AA.
AC   Q645J3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Sigma non-opioid intracellular receptor 1;
DE   AltName: Full=Sigma 1-type opioid receptor;
DE            Short=Sigma1-receptor;
DE            Short=Sigma1R;
GN   Name=SIGMAR1; Synonyms=OPRS1;
OS   Taricha granulosa (Roughskin newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae; Taricha.
OX   NCBI_TaxID=8321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Bradford C.S., Moore F.L.;
RT   "Cloning, expression, and characterization of a sigma receptor from the
RT   brain of the rough-skinned newt, Taricha granulosa.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function in lipid transport from the endoplasmic
CC       reticulum and be involved in a wide array of cellular functions
CC       probably through regulation of the biogenesis of lipid microdomains at
CC       the plasma membrane. May regulate calcium efflux at the endoplasmic
CC       reticulum (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer (By similarity). {ECO:0000250|UniProtKB:Q99720}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q99720}. Nucleus outer membrane
CC       {ECO:0000250|UniProtKB:Q99720}. Nucleus envelope
CC       {ECO:0000250|UniProtKB:Q99720}. Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q99720}. Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q99720}. Membrane
CC       {ECO:0000250|UniProtKB:Q99720}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q99720}. Note=During interphase, detected at the
CC       inner and outer nuclear membrane and the endoplasmic reticulum.
CC       Detected on cytoplasmic vesicles during mitosis (By similarity).
CC       Targeted to lipid droplets, cholesterol and galactosylceramide-enriched
CC       domains of the endoplasmic reticulum (By similarity).
CC       {ECO:0000250|UniProtKB:O55242, ECO:0000250|UniProtKB:Q99720}.
CC   -!- DOMAIN: The C-terminal helices form a flat, hydrophobic surface that is
CC       probably tightly associated with the cytosolic surface of the
CC       endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q99720}.
CC   -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC       1 and Sigma-2) based on their different pharmacological profile.
CC       {ECO:0000250|UniProtKB:Q5BJF2}.
CC   -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
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DR   EMBL; AY726668; AAU34079.1; -; mRNA.
DR   AlphaFoldDB; Q645J3; -.
DR   SMR; Q645J3; -.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR   PANTHER; PTHR10868; PTHR10868; 1.
DR   Pfam; PF04622; ERG2_Sigma1R; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Lipid transport; Membrane;
KW   Nucleus; Receptor; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..223
FT                   /note="Sigma non-opioid intracellular receptor 1"
FT                   /id="PRO_0000268659"
FT   TOPO_DOM        1..7
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q99720"
FT   TRANSMEM        8..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q99720"
FT   TOPO_DOM        30..223
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q99720"
FT   REGION          98..105
FT                   /note="Important for ligand-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q60492"
FT   REGION          176..223
FT                   /note="C-terminal hydrophobic region"
FT                   /evidence="ECO:0000305"
FT   SITE            125
FT                   /note="Important for ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q99720"
FT   SITE            171
FT                   /note="Important for ligand binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q99720"
SQ   SEQUENCE   223 AA;  24848 MW;  41B70D7818D57B1D CRC64;
     MAVLSSRAMR AALGLAVLAV VIQLLRTWLS SKSYLFNQKD IAELAKQHAG MDFEVAFSKI
     IVELRKKHPG HILPDEDLQW IFVNAGGWMG SMCLLHASLT EYILLFGTAI DTGGHSGRYW
     ADISDTVITG TFRQWKEGTT KSEVFYPGDT IVHVAGEATS VHWSGGTWMV EYGRGFIPST
     MGFALADTIF STQDFCTLFY TFRIYARCLL LETHTYLSEL GLS