SGMR1_XENLA
ID SGMR1_XENLA Reviewed; 221 AA.
AC Q6DCU6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Sigma non-opioid intracellular receptor 1;
DE AltName: Full=Sigma 1-type opioid receptor;
DE Short=Sigma1-receptor;
DE Short=Sigma1R;
GN Name=sigmar1; Synonyms=oprs1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function in lipid transport from the endoplasmic
CC reticulum and be involved in a wide array of cellular functions
CC probably through regulation of the biogenesis of lipid microdomains at
CC the plasma membrane. May regulate calcium efflux at the endoplasmic
CC reticulum (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer (By similarity). {ECO:0000250|UniProtKB:Q99720}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus outer membrane
CC {ECO:0000250|UniProtKB:Q99720}. Nucleus envelope
CC {ECO:0000250|UniProtKB:Q99720}. Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q99720}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q99720}. Membrane
CC {ECO:0000250|UniProtKB:Q99720}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q99720}. Note=During interphase, detected at the
CC inner and outer nuclear membrane and the endoplasmic reticulum.
CC Detected on cytoplasmic vesicles during mitosis (By similarity).
CC Targeted to lipid droplets, cholesterol and galactosylceramide-enriched
CC domains of the endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:O55242, ECO:0000250|UniProtKB:Q99720}.
CC -!- DOMAIN: The C-terminal helices form a flat, hydrophobic surface that is
CC probably tightly associated with the cytosolic surface of the
CC endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q99720}.
CC -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC 1 and Sigma-2) based on their different pharmacological profile.
CC {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SIMILARITY: Belongs to the ERG2 family. {ECO:0000305}.
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DR EMBL; BC077894; AAH77894.1; -; mRNA.
DR RefSeq; NP_001087013.1; NM_001093544.1.
DR PDB; 7W2B; X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2C; X-ray; 3.33 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2D; X-ray; 3.47 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2E; X-ray; 3.56 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2F; X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2G; X-ray; 2.85 A; A/B/C/D/E/F/G/H/I/J/K/L=1-221.
DR PDB; 7W2H; X-ray; 3.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-221.
DR PDBsum; 7W2B; -.
DR PDBsum; 7W2C; -.
DR PDBsum; 7W2D; -.
DR PDBsum; 7W2E; -.
DR PDBsum; 7W2F; -.
DR PDBsum; 7W2G; -.
DR PDBsum; 7W2H; -.
DR AlphaFoldDB; Q6DCU6; -.
DR SMR; Q6DCU6; -.
DR DNASU; 446848; -.
DR GeneID; 446848; -.
DR KEGG; xla:446848; -.
DR CTD; 446848; -.
DR Xenbase; XB-GENE-6255099; sigmar1.L.
DR OMA; LWATTRI; -.
DR OrthoDB; 1285317at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 446848; Expressed in internal ear and 19 other tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR006716; ERG2_sigma1_rcpt-like.
DR PANTHER; PTHR10868; PTHR10868; 1.
DR Pfam; PF04622; ERG2_Sigma1R; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasmic vesicle; Endoplasmic reticulum; Lipid transport;
KW Membrane; Nucleus; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..221
FT /note="Sigma non-opioid intracellular receptor 1"
FT /id="PRO_0000268660"
FT TOPO_DOM 1..4
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT TOPO_DOM 28..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT REGION 96..103
FT /note="Important for ligand-binding"
FT /evidence="ECO:0000250|UniProtKB:Q60492"
FT REGION 174..221
FT /note="C-terminal hydrophobic region"
FT /evidence="ECO:0000305"
FT SITE 123
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
FT SITE 169
FT /note="Important for ligand binding"
FT /evidence="ECO:0000250|UniProtKB:Q99720"
SQ SEQUENCE 221 AA; 24695 MW; D0D9626B03D07EA6 CRC64;
MALWLGLRAV LVVAGLAVLL QLIRGWLSSK SYVFNREEIA RLAKEHSGLD YEVAFSKIIV
ELRKKHPGHI LQDEDLQWVF VNAGGWMGSM CLLHASLTEY VLLFGTAVDT GGHSGRYWAE
ISDTILSGTF RQWKEGTTKS EIFYPGDTIV HEVGEATSVQ WSSGTWMVEY GRGFIPSTLA
FALADTIFST QDFLTLFYTV KVYSKALLLE ASTHLSQLGF F
