SGMR2_BOVIN
ID SGMR2_BOVIN Reviewed; 176 AA.
AC Q3MHW7; A1L510;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Sigma intracellular receptor 2 {ECO:0000303|PubMed:28559337};
DE Short=Sigma-2 receptor {ECO:0000303|PubMed:28559337};
DE Short=Sigma2 receptor {ECO:0000303|PubMed:28559337};
DE AltName: Full=Transmembrane protein 97;
GN Name=TMEM97; Synonyms=S2R {ECO:0000303|PubMed:28559337};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=28559337; DOI=10.1073/pnas.1705154114;
RA Alon A., Schmidt H.R., Wood M.D., Sahn J.J., Martin S.F., Kruse A.C.;
RT "Identification of the gene that codes for the sigma2 receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:7160-7165(2017).
CC -!- FUNCTION: Intracellular orphan receptor that binds numerous drugs and
CC which is highly expressed in various proliferating cells. Corresponds
CC to the sigma-2 receptor, which is thought to play important role in
CC regulating cell survival, morphology and differentiation. May play a
CC role as a regulator of cellular cholesterol homeostasis. May function
CC as sterol isomerase. May alter the activity of some cytochrome P450
CC proteins. {ECO:0000269|PubMed:28559337}.
CC -!- SUBUNIT: Interacts with NPC1. {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q5BJF2};
CC Multi-pass membrane protein {ECO:0000255}. Rough endoplasmic reticulum
CC membrane {ECO:0000250|UniProtKB:Q5BJF2}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in
CC sterol-depleted cells when expression of endogenous TMEM97 is
CC stimulated. {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC 1 and Sigma-2) based on their different pharmacological profile. Sigma-
CC 2 receptors are identified by radioligand-binding studies as a binding
CC site with high affinity for di-o-tolylguanidine (DTG) and haloperidol.
CC {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SIMILARITY: Belongs to the TMEM97/sigma-2 receptor family.
CC {ECO:0000305}.
CC -!- CAUTION: The molecular identity of the sigma-2 receptor has been
CC unclear for a long time. It is now identified as TMEM97
CC (PubMed:28559337). Previously identified as PGRMC1 (AC O00264).
CC {ECO:0000250|UniProtKB:Q5BJF2, ECO:0000269|PubMed:28559337}.
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DR EMBL; BT029797; ABM06065.1; -; mRNA.
DR EMBL; BC104594; AAI04595.1; -; mRNA.
DR RefSeq; NP_001029575.1; NM_001034403.1.
DR PDB; 7M93; X-ray; 2.94 A; A/B/C/D=1-168.
DR PDB; 7M94; X-ray; 2.71 A; A/B/C/D=1-168.
DR PDB; 7M95; X-ray; 2.41 A; A/B=1-168.
DR PDB; 7M96; X-ray; 2.41 A; A/B/C/D=1-168.
DR PDB; 7MFI; X-ray; 2.81 A; A/B/C/D=1-168.
DR PDBsum; 7M93; -.
DR PDBsum; 7M94; -.
DR PDBsum; 7M95; -.
DR PDBsum; 7M96; -.
DR PDBsum; 7MFI; -.
DR AlphaFoldDB; Q3MHW7; -.
DR SMR; Q3MHW7; -.
DR STRING; 9913.ENSBTAP00000010666; -.
DR PaxDb; Q3MHW7; -.
DR Ensembl; ENSBTAT00000010666; ENSBTAP00000010666; ENSBTAG00000008109.
DR GeneID; 511378; -.
DR KEGG; bta:511378; -.
DR CTD; 27346; -.
DR VEuPathDB; HostDB:ENSBTAG00000008109; -.
DR VGNC; VGNC:36129; TMEM97.
DR eggNOG; ENOG502RZRX; Eukaryota.
DR GeneTree; ENSGT00390000007149; -.
DR HOGENOM; CLU_086812_1_0_1; -.
DR InParanoid; Q3MHW7; -.
DR OMA; FYFASHI; -.
DR OrthoDB; 1459246at2759; -.
DR TreeFam; TF300241; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000008109; Expressed in diaphragm and 105 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005791; C:rough endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
DR InterPro; IPR033118; EXPERA.
DR InterPro; IPR016964; Sigma2_recept.
DR PIRSF; PIRSF031032; TMP_97_prd; 1.
DR PROSITE; PS51751; EXPERA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..176
FT /note="Sigma intracellular receptor 2"
FT /id="PRO_0000254566"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 10..158
FT /note="EXPERA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
FT HELIX 6..27
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 29..31
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 36..38
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 41..54
FT /evidence="ECO:0007829|PDB:7M95"
FT STRAND 57..61
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 64..75
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 77..90
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 94..96
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 97..120
FT /evidence="ECO:0007829|PDB:7M95"
FT TURN 127..131
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 137..147
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 149..163
FT /evidence="ECO:0007829|PDB:7M95"
FT HELIX 165..167
FT /evidence="ECO:0007829|PDB:7M96"
SQ SEQUENCE 176 AA; 20784 MW; 320AEFE88377504A CRC64;
MGTLGARRGL EWFLGFYFLS HIPITLLMDL QGVLPRDLYP VELRNLQQWY IEEFKDPLLQ
TPPAWFKSFL FCELVFQLPF FPIAAYAFFK GGCKWIRTPA IIYSVHTMTT LIPILSTLLL
DDFSKASHFR GQGPKTFQER LFLISVYIPY FLIPLILLLF MVRNPYYKSE EKRKKK
