SGMR2_RAT
ID SGMR2_RAT Reviewed; 176 AA.
AC Q5U3Y7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Sigma intracellular receptor 2 {ECO:0000250|UniProtKB:Q5BJF2};
DE Short=Sigma-2 receptor {ECO:0000250|UniProtKB:Q5BJF2};
DE Short=Sigma2 receptor {ECO:0000250|UniProtKB:Q5BJF2};
DE AltName: Full=Transmembrane protein 97;
GN Name=Tmem97; Synonyms=S2r {ECO:0000250|UniProtKB:Q5BJF2};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Intracellular orphan receptor that binds numerous drugs and
CC which is highly expressed in various proliferating cells. Corresponds
CC to the sigma-2 receptor, which is thought to play important role in
CC regulating cell survival, morphology and differentiation. May play a
CC role as a regulator of cellular cholesterol homeostasis. May function
CC as sterol isomerase. May alter the activity of some cytochrome P450
CC proteins. {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SUBUNIT: Interacts with NPC1. {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q5BJF2};
CC Multi-pass membrane protein {ECO:0000255}. Rough endoplasmic reticulum
CC membrane {ECO:0000250|UniProtKB:Q5BJF2}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in
CC sterol-depleted cells when expression of endogenous TMEM97 is
CC stimulated. {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- MISCELLANEOUS: Sigma receptors are classified into two subtypes (Sigma-
CC 1 and Sigma-2) based on their different pharmacological profile. Sigma-
CC 2 receptors are identified by radioligand-binding studies as a binding
CC site with high affinity for di-o-tolylguanidine (DTG) and haloperidol.
CC {ECO:0000250|UniProtKB:Q5BJF2}.
CC -!- SIMILARITY: Belongs to the TMEM97/sigma-2 receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC085344; AAH85344.1; -; mRNA.
DR RefSeq; NP_001008335.1; NM_001008334.1.
DR AlphaFoldDB; Q5U3Y7; -.
DR SMR; Q5U3Y7; -.
DR STRING; 10116.ENSRNOP00000011834; -.
DR BindingDB; Q5U3Y7; -.
DR ChEMBL; CHEMBL4105864; -.
DR GuidetoPHARMACOLOGY; 2553; -.
DR PaxDb; Q5U3Y7; -.
DR PRIDE; Q5U3Y7; -.
DR Ensembl; ENSRNOT00000011808; ENSRNOP00000011834; ENSRNOG00000008704.
DR GeneID; 303330; -.
DR KEGG; rno:303330; -.
DR CTD; 27346; -.
DR RGD; 1307423; Tmem97.
DR eggNOG; ENOG502RZRX; Eukaryota.
DR GeneTree; ENSGT00940000158363; -.
DR HOGENOM; CLU_086812_1_0_1; -.
DR InParanoid; Q5U3Y7; -.
DR OMA; FYFASHI; -.
DR OrthoDB; 1459246at2759; -.
DR PhylomeDB; Q5U3Y7; -.
DR TreeFam; TF300241; -.
DR PRO; PR:Q5U3Y7; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000022657; Expressed in pancreas and 20 other tissues.
DR Genevisible; Q5U3Y7; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005791; C:rough endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
DR InterPro; IPR033118; EXPERA.
DR InterPro; IPR016964; Sigma2_recept.
DR PIRSF; PIRSF031032; TMP_97_prd; 1.
DR PROSITE; PS51751; EXPERA; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..176
FT /note="Sigma intracellular receptor 2"
FT /id="PRO_0000254570"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..140
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 10..158
FT /note="EXPERA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01087"
SQ SEQUENCE 176 AA; 20946 MW; 949F3A588243B486 CRC64;
MGAVTARRCV EWLLGLYFVS HIPITMFIDL QALLPPELYP QEFSNLLRWY SKEFKDPLMQ
EPPVWFKSFL FCELVFQLPF FPIAAYAFFK GSCRWIRIPA IIYAVHTITT LIPILYTILF
EDFSKAIAFK GQRPENFRER LTLVGVYAPY LIIPLILLLF MLRNPYYKFE EKRKKK
