SGO1_ARATH
ID SGO1_ARATH Reviewed; 572 AA.
AC F4J3S1; Q9SQX5;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=SHUGOSHIN 1 {ECO:0000303|PubMed:23884434};
DE Short=AtSGO1 {ECO:0000303|PubMed:23884434};
GN Name=SGO1 {ECO:0000303|PubMed:23884434};
GN OrderedLocusNames=At3g10440 {ECO:0000312|Araport:AT3G10440};
GN ORFNames=F13M14.28 {ECO:0000312|EMBL:AAG51375.1},
GN F18K10.2 {ECO:0000312|EMBL:AAF76346.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION.
RX PubMed=24206843; DOI=10.1016/j.cub.2013.08.036;
RA Cromer L., Jolivet S., Horlow C., Chelysheva L., Heyman J., De Jaeger G.,
RA Koncz C., De Veylder L., Mercier R.;
RT "Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at
RT anaphase I and by PATRONUS at interkinesis.";
RL Curr. Biol. 23:2090-2099(2013).
RN [4]
RP FUNCTION.
RX PubMed=23884434; DOI=10.1007/s00497-013-0231-x;
RA Zamariola L., De Storme N., Tiang C.L., Armstrong S.J., Franklin F.C.,
RA Geelen D.;
RT "SGO1 but not SGO2 is required for maintenance of centromere cohesion in
RT Arabidopsis thaliana meiosis.";
RL Plant Reprod. 26:197-208(2013).
RN [5]
RP FUNCTION.
RX PubMed=24506176; DOI=10.1111/tpj.12432;
RA Zamariola L., De Storme N., Vannerum K., Vandepoele K., Armstrong S.J.,
RA Franklin F.C., Geelen D.;
RT "SHUGOSHINs and PATRONUS protect meiotic centromere cohesion in Arabidopsis
RT thaliana.";
RL Plant J. 77:782-794(2014).
CC -!- FUNCTION: Protects sister chromatid centromere cohesion in meiosis I
CC but not through the protection of the cohesin SYN1 (PubMed:23884434).
CC Required with SGO2 for full protection of centromeric cohesion during
CC anaphase I (PubMed:24206843). Required to prevent precocious release of
CC pericentromeric cohesins during meiosis (PubMed:24206843). Not
CC necessary for the maintenance of the synaptonemal complex (SC)
CC (PubMed:23884434). Not required for monopolar spindle orientation in
CC meiosis I (PubMed:24506176). {ECO:0000269|PubMed:23884434,
CC ECO:0000269|PubMed:24206843, ECO:0000269|PubMed:24506176}.
CC -!- MISCELLANEOUS: Knock-down mutants show meiotic defects, reduction in
CC seed set and fertility, and premature separation of sister chromatids
CC before meiosis II, but no defects in vegetative development or growth
CC (PubMed:24206843, PubMed:23884434). The localization of SYN1 and ZYP1
CC are not affected (PubMed:23884434). Sgo1 and sgo2 double mutants are
CC almost completely sterile and show a premature separation of sister
CC chromatids at anaphase I (PubMed:24506176).
CC {ECO:0000269|PubMed:23884434, ECO:0000269|PubMed:24206843,
CC ECO:0000269|PubMed:24506176}.
CC -!- MISCELLANEOUS: Shugoshin is Japanese for guardian spirit.
CC {ECO:0000305|PubMed:24206843}.
CC -!- SIMILARITY: Belongs to the shugoshin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF76346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51375.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011560; AAG51375.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC013428; AAF76346.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74907.1; -; Genomic_DNA.
DR RefSeq; NP_187655.2; NM_111879.3.
DR AlphaFoldDB; F4J3S1; -.
DR SMR; F4J3S1; -.
DR STRING; 3702.AT3G10440.1; -.
DR PaxDb; F4J3S1; -.
DR PRIDE; F4J3S1; -.
DR EnsemblPlants; AT3G10440.1; AT3G10440.1; AT3G10440.
DR GeneID; 820208; -.
DR Gramene; AT3G10440.1; AT3G10440.1; AT3G10440.
DR KEGG; ath:AT3G10440; -.
DR Araport; AT3G10440; -.
DR TAIR; locus:2075770; AT3G10440.
DR eggNOG; ENOG502RYDC; Eukaryota.
DR HOGENOM; CLU_029160_0_0_1; -.
DR InParanoid; F4J3S1; -.
DR OrthoDB; 947253at2759; -.
DR PRO; PR:F4J3S1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J3S1; baseline and differential.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0034090; P:maintenance of meiotic sister chromatid cohesion; IGI:TAIR.
DR InterPro; IPR044693; SGO_plant.
DR InterPro; IPR011515; Shugoshin_C.
DR PANTHER; PTHR34373; PTHR34373; 2.
DR Pfam; PF07557; Shugoshin_C; 1.
PE 3: Inferred from homology;
KW Chromosome partition; Coiled coil; Reference proteome.
FT CHAIN 1..572
FT /note="SHUGOSHIN 1"
FT /id="PRO_0000438546"
FT REGION 185..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..110
FT /evidence="ECO:0000255"
FT COMPBIAS 187..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63946 MW; C8B73B76693A70BD CRC64;
MVRATVLNVG DHASEGVRTN KAKGEKMVLE PPMNSAQRRK LGDITNLQNQ KNLMNQGAKH
QQQAILISSK ENAENLQKEN TKLMKVVMER DGIKSDLKKL RIEFQKVQEQ NLLLAQANTR
ILAEFNTSKD QLKVLQHELG CKNGLVMARK MLLKEQTLPC TRHASKVKAQ ANACGGACKT
FQPNDADHEH ASGSSNANSL QRNEKANSKR RVSGRKNPAN SEVLDIIGRS GETCQMEDNI
DNKKLVSDSD NDAENHINDN VQSKRYCAGR QSSSSKTREA SQTETLQKVV DAKEIKGDAR
FSLTKHSDWL KSQEPEPSES LYESRFPLRR RSARLKSQEP EPSESFHDSI ETTKRRRSAI
RSAMFNIQEL GVIQNLNGLP DDQEIAAKAR CSAREQSTGS KPEAVEPHDT KEIIGKSRIS
LRRQSARFNF QELGVTENLN GPHDDQTIAA NARCCASEQS IGSKPEAVEP HDIEERIGKI
RVSSRRQSAN IETPRAIKEP ANPPLHDDNV EESSQISCSV SMELKRESKK KPTGDESEEM
RKTTVGRPSR QAAEKIKSYK EPSLKEKMRG GF
