ID   SGO1_ASHGO              Reviewed;         648 AA.
AC   Q759Q5;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Shugoshin;
GN   Name=SGO1; OrderedLocusNames=ADR218W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 264.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Plays a central role in chromosome cohesion during cell
CC       division by preventing premature dissociation of cohesin complex from
CC       centromeres after prophase, when most of cohesin complex dissociates
CC       from chromosomes arms. May act by protecting RAD21 and or REC8 from
CC       cleavage by ESP1/separase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shugoshin family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS52138.2; -; Genomic_DNA.
DR   RefSeq; NP_984314.2; NM_209667.2.
DR   AlphaFoldDB; Q759Q5; -.
DR   SMR; Q759Q5; -.
DR   STRING; 33169.AAS52138; -.
DR   EnsemblFungi; AAS52138; AAS52138; AGOS_ADR218W.
DR   GeneID; 4620476; -.
DR   KEGG; ago:AGOS_ADR218W; -.
DR   eggNOG; ENOG502QSMK; Eukaryota.
DR   HOGENOM; CLU_019322_0_0_1; -.
DR   InParanoid; Q759Q5; -.
DR   OMA; SKIKHSM; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IEA:InterPro.
DR   InterPro; IPR011515; Shugoshin_C.
DR   InterPro; IPR011516; Shugoshin_N.
DR   Pfam; PF07557; Shugoshin_C; 1.
DR   Pfam; PF07558; Shugoshin_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..648
FT                   /note="Shugoshin"
FT                   /id="PRO_0000055445"
FT   REGION          188..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          95..122
FT                   /evidence="ECO:0000255"
FT   COILED          208..273
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        198..232
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..302
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  72330 MW;  243258FD60F212D4 CRC64;
     MYKKVVGGWF VYLVSTQISS GRAGSARFGG HLGYPSPSVA YIMARASRKA NGSKAKSNSV
     QEYLDLISLQ KQQFDQMRAN YSHQNTQLAK SNSMLMIKIT DLETKISELV QENVQLRSRL
     SVTELRFKER LNQSFNLLEH GAFQRFDEIV NLFAVVRAQQ GLRPESAAAT EQAQRRFKGL
     EQRGVSPKVV GFDVPSSDSV RGERETLDDR AQQHQEADSM ELNVEETQPL RKKRRRSSRR
     ESLFIPSDFD FSNDSLENAL KEADKSRSAK DEAPSVAEDT ITEEKHRESA SRTTEQGESE
     SRTKEASGTL TQSNEDGMGN DKSLQKEGTQ QEDAANFTHS IIEYFIPEEY DVGSSDVANT
     SKSKLEVYRD DNEIESSQST SSGECKELTG ELSSAQPPFV QIPASSQSKI KHSLKPPRTS
     QRKIVVDEVM PHNDYSDATR PRRTRGKAVD YKWPSLRAKM RRPTDKLVDA TTVTDIHELQ
     VPTNRKLRKQ REGVADSADV HGETDHEQDP EQSPAAEDVS VGLQSINSNI QKDEVSDQPL
     QATEVTQALP EDLPLRQPMA LKDITNKIHI VQKPKKSLAK KPIIGDVSDE NSYYGDDTSA
     SGLRLNEGDL SVFDLIGGVK CSNIPKTHRA RAKAERQVGK KPAFKVST