ID   SGO1_KLULA              Reviewed;         594 AA.
AC   Q6CXI9;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Shugoshin;
GN   Name=SGO1; OrderedLocusNames=KLLA0A07865g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a central role in chromosome cohesion during cell
CC       division by preventing premature dissociation of cohesin complex from
CC       centromeres after prophase, when most of cohesin complex dissociates
CC       from chromosomes arms. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shugoshin family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02938.1; -; Genomic_DNA.
DR   RefSeq; XP_451350.1; XM_451350.1.
DR   AlphaFoldDB; Q6CXI9; -.
DR   SMR; Q6CXI9; -.
DR   STRING; 28985.XP_451350.1; -.
DR   PRIDE; Q6CXI9; -.
DR   EnsemblFungi; CAH02938; CAH02938; KLLA0_A07865g.
DR   GeneID; 2896704; -.
DR   KEGG; kla:KLLA0_A07865g; -.
DR   eggNOG; ENOG502QSMK; Eukaryota.
DR   HOGENOM; CLU_019322_0_0_1; -.
DR   InParanoid; Q6CXI9; -.
DR   OMA; SKIKHSM; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IEA:InterPro.
DR   InterPro; IPR011515; Shugoshin_C.
DR   InterPro; IPR011516; Shugoshin_N.
DR   Pfam; PF07557; Shugoshin_C; 1.
DR   Pfam; PF07558; Shugoshin_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..594
FT                   /note="Shugoshin"
FT                   /id="PRO_0000055448"
FT   REGION          104..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          38..61
FT                   /evidence="ECO:0000255"
FT   COILED          220..240
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        145..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..380
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  67250 MW;  957AE5DA45041E26 CRC64;
     MSASSQYDEF QAMLEQQKGI YLQQNSQLAK YNSSLMMKIT DMETKVSELV QENVSLRSRL
     SMGELRYREK LNTVFQTLED GIVEKFLQMN QLLTTVRESQ GLESGIHDNP LKPILRGSNG
     ISPRSAKKVE FTGANTTTKP VGFEDPIAED NHENSGNSLE LNDDEVRPLR KRRRKSSRRE
     SLFIPADFEF NDEDPELELN QLPITEDEPP PSTAATSVPE EESQENKHTK EEREDEGKEN
     VSTIPLVPVL PSVTNTGTEC SNTNKNNTTE METALAEDDS YNFTTSVIEY SIPEETSTHE
     HSHILLETSK SKIDVYNDRE ETNNNEADDS MNIVQCTIPS QSKIKHSMKH PRTKLKGGQD
     DIMPHTDYDK DDEKRERRTR GKAVNYKLPS LRAKMRRPTE KLVDATTVTD IHDLQVKRRN
     NQQQGIPSDD DDQEELLVPA GVPDTNVVIA TVEEENRKEP PALPLHEIHL AQNVKPKIAL
     KELSANAINR KVKTSTAVKA ISHTKSRVLK DVKFNTLPTK QQAIENNSSD PNVSDENENS
     NVKPTRTKQA TSDLAAFEII DGISLKHVSR THRVRAKEDM NKKRKRIHND EISI