ID   SGO1_NEUCR              Reviewed;         774 AA.
AC   Q872U8; Q1K569;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Shugoshin;
GN   Name=sgo-1; ORFNames=B23G1.060, NCU01842;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Plays a central role in chromosome cohesion during cell
CC       division by preventing premature dissociation of cohesin complex from
CC       centromeres after prophase, when most of cohesin complex dissociates
CC       from chromosomes arms. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the shugoshin family. {ECO:0000305}.
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DR   EMBL; BX284754; CAD70468.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA27390.1; -; Genomic_DNA.
DR   RefSeq; XP_956626.1; XM_951533.2.
DR   AlphaFoldDB; Q872U8; -.
DR   SMR; Q872U8; -.
DR   STRING; 5141.EFNCRP00000001736; -.
DR   PRIDE; Q872U8; -.
DR   EnsemblFungi; EAA27390; EAA27390; NCU01842.
DR   GeneID; 3872773; -.
DR   KEGG; ncr:NCU01842; -.
DR   VEuPathDB; FungiDB:NCU01842; -.
DR   HOGENOM; CLU_013723_1_0_1; -.
DR   InParanoid; Q872U8; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0000793; C:condensed chromosome; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IEA:InterPro.
DR   InterPro; IPR038889; Shugoshin.
DR   InterPro; IPR011515; Shugoshin_C.
DR   InterPro; IPR011516; Shugoshin_N.
DR   PANTHER; PTHR21577; PTHR21577; 1.
DR   Pfam; PF07557; Shugoshin_C; 1.
DR   Pfam; PF07558; Shugoshin_N; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..774
FT                   /note="Shugoshin"
FT                   /id="PRO_0000055449"
FT   REGION          106..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          676..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          41..105
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        110..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..500
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..608
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..661
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  84750 MW;  B3B5C86E1DA3D2B2 CRC64;
     MARLNEQAMS SVALSTDNLE LLRRKFLRQN RDIARVNSTQ SLRIRGLENE CARLLSENLE
     LRGQVLRLEK ELQDNAARRV ADHALEVKAK METQLAELSS LLASLGEPPS KRRLSEERRY
     AQPRPSVHRS PPLRRARQEA DQELLAEQEG RLPPIYENKT YARATMNSEE ILALCMQADD
     SNDSPDIGPP PVSRFVEDDM VIPCSPSPNK NAEAEETETT EQVEESPRAL QVPPSLSPPK
     LDYDRRPNMI LFSPPKESRV AEPSKMFSPP PMEPPKQSTS AVPSETIRAG LKRKLNGDNQ
     NEPNKATKLQ QGKENGNETG IKKGLSARDP HKRKSIKETA TKPRAPLSAK STNEHIVSPK
     KPAKPHQVAD DFKPVKVHKA SKGKEKVDLP APDKKSAVEE TQGNSTSAFT KVEILPPALE
     PTPEVAEIPE TDILITPGTP ERASESTVVT HDTPPPAHIS SNGETSRPSR RARAAISYTE
     PNLRDKMRRP TKELFDAVSG EGKFLHRPTS QQQQQQRKGD ESAPTSVSKV KVEPSPAVDI
     SSLTSSALFE KEKEKEPQPD EGILSPNGIL PSSVDLGRRR RASSFSTAAP AMTIPSVQEQ
     STLNLPAADE TDENAAVEAQ IQKELSNSIT TRPRGGKGRQ SMSRSVPTIP TENYEHEDAQ
     LSTNSASVDL YDFASCASPD SAAPQLEATT GDVPVNKKAP KGSRRASSAA STETTATASA
     KPRSSRKRAS MLVPKKSLWA EELAQEEEDE EDVGNDSGGS LSKGRASRRR SMML