SGQP_PINMA
ID SGQP_PINMA Reviewed; 329 AA.
AC P86957;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 15.
DE RecName: Full=Serine, glycine and glutamine-rich protein;
DE AltName: Full=Cement-like protein;
DE Flags: Precursor;
OS Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX NCBI_TaxID=104660;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RC TISSUE=Mantle {ECO:0000269|PubMed:19915030};
RX PubMed=19915030; DOI=10.1093/molbev/msp278;
RA Jackson D.J., McDougall C., Woodcroft B., Moase P., Rose R.A., Kube M.,
RA Reinhardt R., Rokhsar D.S., Montagnani C., Joubert C., Piquemal D.,
RA Degnan B.M.;
RT "Parallel evolution of nacre building gene sets in molluscs.";
RL Mol. Biol. Evol. 27:591-608(2010).
RN [2]
RP PROTEIN SEQUENCE OF 157-185, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Shell;
RX PubMed=23213212; DOI=10.1073/pnas.1210552109;
RA Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C.,
RA Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.;
RT "Different secretory repertoires control the biomineralization processes of
RT prism and nacre deposition of the pearl oyster shell.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23213212}.
CC -!- TISSUE SPECIFICITY: Prismatic layer of shell (at protein level).
CC Expressed primarily in the mantle with highest level in the mantle edge
CC and lower level in the mantle pallium. {ECO:0000269|PubMed:23213212}.
CC -!- SEQUENCE CAUTION:
CC Sequence=GT280522; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT282355; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT283025; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT283045; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT283910; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT284086; Type=Miscellaneous discrepancy; Note=Premature stop codon at position 267.; Evidence={ECO:0000305};
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DR EMBL; GT277953; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT278035; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT278036; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT278792; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279484; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279521; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279611; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279751; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279966; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279968; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280339; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT280522; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281542; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281803; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281882; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282355; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282683; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282847; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282988; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283025; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283045; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283282; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283657; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283748; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283791; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283910; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283947; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284086; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284367; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EZ420120; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P86957; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..329
FT /note="Serine, glycine and glutamine-rich protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413083"
FT REGION 38..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 9
FT /note="V -> P (in Ref. 1; GT283910)"
FT /evidence="ECO:0000305"
FT CONFLICT 107..108
FT /note="GG -> SP (in Ref. 1; GT283282)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="G -> D (in Ref. 1; GT278035)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="G -> R (in Ref. 1; GT278035)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="K -> Q (in Ref. 1; GT278035)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="G -> S (in Ref. 1; GT283947)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="G -> S (in Ref. 1; GT284367)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="R -> S (in Ref. 1; GT278792)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="V -> L (in Ref. 1; GT283025)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="S -> I (in Ref. 1; GT283025)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="I -> F (in Ref. 1; GT279611)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="G -> C (in Ref. 1; GT283025)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="G -> C (in Ref. 1; GT283025)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="R -> I (in Ref. 1; GT278792)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="G -> R (in Ref. 1; GT283910)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="H -> P (in Ref. 1; GT278036)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="H -> R (in Ref. 1; GT284086)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="N -> H (in Ref. 1; GT278792)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="G -> S (in Ref. 1; GT280339)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="H -> P (in Ref. 1; GT278036)"
FT /evidence="ECO:0000305"
FT CONFLICT 232
FT /note="Q -> P (in Ref. 1; GT278036)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="Q -> R (in Ref. 1; GT284086)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="V -> F (in Ref. 1; GT278036)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="Q -> H (in Ref. 1; GT278036)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="Q -> P (in Ref. 1; GT283045)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="R -> K (in Ref. 1; GT277953)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="G -> S (in Ref. 1; GT282988/GT279484)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="S -> T (in Ref. 1; GT277953)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 32486 MW; EDCF34FEE84E873B CRC64;
MKTVLLFVVL VGLAYCDDDG WDMGNFFQQY HQWQQQISSS SSSSSSSSSG GGGSSGGGAS
GGGGGSSSGG GGASGGGGGG SSGGGGLTKV VLKAGGGGGG GFKSVGGGRG GVTKLVASGG
ASGGGSVSGG GGGSLALLAG GSAAGGGRSG VVTVSKQPII INRQVTHVNT GGSGGGVGGG
FGGGRGGFGY GLYGGYHHYN PCGYGQVYSY YYGCQSIYKQ PARQVYHQPV YQPVQTVHQP
VQYYQQPYQY QHSYGQPSYA YQPQTTKYIS YSYPQYSSQG SYPTVAGGSA GGFVRGSSGG
MGFSSGGIGG HSSYPLSVFK HAKGEKYKL
