SGRR_ECO57
ID SGRR_ECO57 Reviewed; 552 AA.
AC Q8XA02; Q7AHR6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN OrderedLocusNames=Z0079, ECs0074;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC stress conditions as well as yfdZ. Represses its own transcription
CC under both stress and non-stress conditions. Might act as a sensor of
CC the intracellular accumulation of phosphoglucose by binding these
CC molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC Rule:MF_01449}.
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DR EMBL; AE005174; AAG54374.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB33497.1; -; Genomic_DNA.
DR PIR; B85489; B85489.
DR PIR; B90638; B90638.
DR RefSeq; NP_308101.1; NC_002695.1.
DR RefSeq; WP_001138626.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8XA02; -.
DR SMR; Q8XA02; -.
DR STRING; 155864.EDL933_0072; -.
DR EnsemblBacteria; AAG54374; AAG54374; Z0079.
DR EnsemblBacteria; BAB33497; BAB33497; ECs_0074.
DR GeneID; 913502; -.
DR KEGG; ece:Z0079; -.
DR KEGG; ecs:ECs_0074; -.
DR PATRIC; fig|386585.9.peg.174; -.
DR eggNOG; COG4533; Bacteria.
DR HOGENOM; CLU_017028_12_3_6; -.
DR OMA; WLTWQAE; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01449; HTH_type_SgrR; 1.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR000914; SBP_5_dom.
DR InterPro; IPR025370; SgrR_HTH_N.
DR InterPro; IPR023767; Tscrpt_reg_SgrR.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR Pfam; PF12793; SgrR_N; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..552
FT /note="HTH-type transcriptional regulator SgrR"
FT /id="PRO_0000309242"
FT DOMAIN 1..116
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT DNA_BIND 26..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT REGION 163..492
FT /note="Solute-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ SEQUENCE 552 AA; 64120 MW; E4199F7F23E8C23E CRC64;
MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTITSEKPAG LESLTLTFYQ DHSEHRVIAG
IMQQILASHQ VTLEIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
IPIDWQVDAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
FKSAWFAPPD PE
