ID   SGRR_ECOL6              Reviewed;         551 AA.
AC   Q8FL80;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=c0085;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions. Might act as a sensor of
CC       the intracellular accumulation of phosphoglucose by binding these
CC       molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01449}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN78581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN78581.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001314420.1; NC_004431.1.
DR   AlphaFoldDB; Q8FL80; -.
DR   SMR; Q8FL80; -.
DR   STRING; 199310.c0085; -.
DR   EnsemblBacteria; AAN78581; AAN78581; c0085.
DR   KEGG; ecc:c0085; -.
DR   eggNOG; COG4533; Bacteria.
DR   HOGENOM; CLU_017028_12_3_6; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..551
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000309244"
FT   DOMAIN          1..116
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   REGION          163..492
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ   SEQUENCE   551 AA;  64003 MW;  AADE677BE7E3858A CRC64;
     MPSARLQQQF IRLWQCCEGK SQETTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
     ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
     RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIANI VSPTPWTLDI HLTQPDRWLP
     LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
     VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
     SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG
     IMQQILASHQ VTLEIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
     IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
     FKSAWFAPPD P