SGRR_ECOLI
ID SGRR_ECOLI Reviewed; 551 AA.
AC P33595; P75638;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=HTH-type transcriptional regulator SgrR;
GN Name=sgrR; Synonyms=yabN; OrderedLocusNames=b0069, JW0068;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1630901; DOI=10.1093/nar/20.13.3305;
RA Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K.,
RA Mizobuchi K., Nakata A.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 0-
RT 2.4 min region.";
RL Nucleic Acids Res. 20:3305-3308(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION TO
RP 356; 384 AND 409.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RX PubMed=15522088; DOI=10.1111/j.1365-2958.2004.04348.x;
RA Vanderpool C.K., Gottesman S.;
RT "Involvement of a novel transcriptional activator and small RNA in post-
RT transcriptional regulation of the glucose phosphoenolpyruvate
RT phosphotransferase system.";
RL Mol. Microbiol. 54:1076-1089(2004).
RN [5]
RP FUNCTION AS A TRANSCRIPTIONAL REGULATOR.
RX PubMed=17209026; DOI=10.1128/jb.01689-06;
RA Vanderpool C.K., Gottesman S.;
RT "The novel transcription factor SgrR coordinates the response to glucose-
RT phosphate stress.";
RL J. Bacteriol. 189:2238-2248(2007).
CC -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC stress conditions as well as yfdZ. Represses its own transcription
CC under both stress and non-stress conditions; this repression likely
CC provides one measure of control over sgrR at the level of synthesis.
CC Might act as a sensor of the intracellular accumulation of
CC phosphoglucose by binding these molecules in its C-terminal solute-
CC binding domain. {ECO:0000269|PubMed:15522088,
CC ECO:0000269|PubMed:17209026}.
CC -!- MISCELLANEOUS: Binds specifically to sgrS promoter in vitro.
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DR EMBL; U00096; AAC73180.1; -; Genomic_DNA.
DR EMBL; AP009048; BAB96638.2; -; Genomic_DNA.
DR PIR; E64728; E64728.
DR RefSeq; NP_414611.1; NC_000913.3.
DR RefSeq; WP_001138624.1; NZ_STEB01000010.1.
DR AlphaFoldDB; P33595; -.
DR SMR; P33595; -.
DR BioGRID; 4263126; 4.
DR IntAct; P33595; 2.
DR STRING; 511145.b0069; -.
DR jPOST; P33595; -.
DR PaxDb; P33595; -.
DR PRIDE; P33595; -.
DR EnsemblBacteria; AAC73180; AAC73180; b0069.
DR EnsemblBacteria; BAB96638; BAB96638; BAB96638.
DR GeneID; 944788; -.
DR KEGG; ecj:JW0068; -.
DR KEGG; eco:b0069; -.
DR PATRIC; fig|1411691.4.peg.2213; -.
DR EchoBASE; EB2018; -.
DR eggNOG; COG4533; Bacteria.
DR HOGENOM; CLU_017028_12_3_6; -.
DR InParanoid; P33595; -.
DR OMA; WLTWQAE; -.
DR PhylomeDB; P33595; -.
DR BioCyc; EcoCyc:EG12094-MON; -.
DR PRO; PR:P33595; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:EcoCyc.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR HAMAP; MF_01449; HTH_type_SgrR; 1.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR000914; SBP_5_dom.
DR InterPro; IPR025370; SgrR_HTH_N.
DR InterPro; IPR023767; Tscrpt_reg_SgrR.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR Pfam; PF12793; SgrR_N; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..551
FT /note="HTH-type transcriptional regulator SgrR"
FT /id="PRO_0000168522"
FT DOMAIN 1..116
FT /note="HTH marR-type"
FT DNA_BIND 26..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT REGION 163..492
FT /note="Solute-binding"
FT /evidence="ECO:0000255"
SQ SEQUENCE 551 AA; 63975 MW; 0F4FAA1AAFC4E731 CRC64;
MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG
IMQQILASHQ VTLKIKEIDY DQWHTGEIES DIWLNSANFT LPLDFSVFAH LCEVPLLQHC
IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLLHHWL IIQGQRSMRG LRMNTLGWFD
FKSAWFAPPD P
