SGRR_PHOLL
ID SGRR_PHOLL Reviewed; 553 AA.
AC Q7N125;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=plu3677;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC stress conditions as well as yfdZ. Represses its own transcription
CC under both stress and non-stress conditions. Might act as a sensor of
CC the intracellular accumulation of phosphoglucose by binding these
CC molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC Rule:MF_01449}.
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DR EMBL; BX571871; CAE16050.1; -; Genomic_DNA.
DR RefSeq; WP_011147840.1; NC_005126.1.
DR AlphaFoldDB; Q7N125; -.
DR SMR; Q7N125; -.
DR STRING; 243265.plu3677; -.
DR EnsemblBacteria; CAE16050; CAE16050; plu3677.
DR GeneID; 24168650; -.
DR KEGG; plu:plu3677; -.
DR eggNOG; COG4533; Bacteria.
DR HOGENOM; CLU_017028_12_3_6; -.
DR OMA; WLTWQAE; -.
DR OrthoDB; 162819at2; -.
DR BioCyc; PLUM243265:PLU_RS18215-MON; -.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01449; HTH_type_SgrR; 1.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR000914; SBP_5_dom.
DR InterPro; IPR025370; SgrR_HTH_N.
DR InterPro; IPR023767; Tscrpt_reg_SgrR.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR Pfam; PF12793; SgrR_N; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..553
FT /note="HTH-type transcriptional regulator SgrR"
FT /id="PRO_0000309246"
FT DOMAIN 1..117
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT DNA_BIND 26..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT REGION 163..494
FT /note="Solute-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ SEQUENCE 553 AA; 65489 MW; C980D414A9228806 CRC64;
MPSSRLQQQF IRLWQHHQGK EAETTLQELA NVLHCSKRHI RSLLNNMQKA GWLQWQAESG
RGKRSQLNFL RDGWELQQQR AEELLEQHNV EKLVQLVGDK DTVRHMVLSQ IERRFRQGKN
LLRILYYRPF PNLLPGSPLR RSEIHLVRQI FNSLTRINEE NGEPEADLAH HWQQLSSNHW
RFYLRPAIHF HHGRELQMAD VIASLQRLRN LPLFSHIEKV TTPTPYVIDI FLSEPDLWLS
LLIGSPHAMI LPQEWQKLPN FSRMPVGTGP YQVIKNSAQK LQIRAFDNYF GFRALIDQVN
IWFLPELAEK LVCTTLHLES DSTDNNSLDS RIEEGCYFLL HDHRSTKCKR EDVRQWLCSL
LTPINLLAHC DPFYQRHWSP AYGLLLRWHH SKLISELNKP EDITHLTVTL CHQHHEYHTI
SQILQAILTK CGVELKINIV DYDTWFNGNT ESDFWLATAN FYNPLEFSLF ATLYEMPLLK
KCLGNDLSKE VSQWRRQELS LEEWCEKIVD EHWLHPLFHH WLELQGQRSM RGVKMNTFGW
FDFKSAWFNP YEG
