ID   SGRR_SALTY              Reviewed;         552 AA.
AC   Q8ZRV0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=STM0109;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions. Might act as a sensor of
CC       the intracellular accumulation of phosphoglucose by binding these
CC       molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01449}.
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DR   EMBL; AE006468; AAL19073.1; -; Genomic_DNA.
DR   RefSeq; NP_459114.1; NC_003197.2.
DR   RefSeq; WP_001139042.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZRV0; -.
DR   SMR; Q8ZRV0; -.
DR   STRING; 99287.STM0109; -.
DR   PaxDb; Q8ZRV0; -.
DR   EnsemblBacteria; AAL19073; AAL19073; STM0109.
DR   GeneID; 1251627; -.
DR   KEGG; stm:STM0109; -.
DR   PATRIC; fig|99287.12.peg.113; -.
DR   HOGENOM; CLU_017028_12_3_6; -.
DR   PhylomeDB; Q8ZRV0; -.
DR   BioCyc; SENT99287:STM0109-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..552
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000309250"
FT   DOMAIN          1..116
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   REGION          163..493
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ   SEQUENCE   552 AA;  63995 MW;  B7D497D2CD1D4864 CRC64;
     MPSGRLQQQF IRLWQCCDGK TQDTTLNELA DLLNCSRRHM RTLLNTMQAR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK SAVRQMLISH LGRSFRQGRH
     ILRVLYYRPM HNLLPGTALR RSETHIARQI FSSLTRVNEE NGELEADIAH HWQQISPLLW
     RFYLRPGIHF HHGRELEMED VISSLTRINT LPLYSHITKI DSPTAWTLDI HLSQPDRWLP
     WLLGQVPAMI LPRKWETLAN FASHPIGTGP YAVRRNTPNQ LKILAFDDYF GYRALIDEVN
     VWVLPDISEE PACGLMLEGP IQGGEKAIES RLEEGCYYLL FDARTPRGAH PQVREWVSHV
     LSPTNLLYHA DEPLQQLWFP AYGLLPRWHH ARPGPGEKPA GLETLTLTFY REHIEHRVIA
     RIMSALLAEH QVHLHIQEID YDQWHAGEIE SDIWLNSANF TLPLDFSLFA HLCEVPLLQN
     CIPRDWQGDA AQWRAGEMNL ANWCQQLLAN KAIVPLIHHW LIIQGQRSMR GLRMNTLGWF
     DFKSAWFAPP DP