SGRR_SHIDS
ID SGRR_SHIDS Reviewed; 552 AA.
AC Q32K24;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=SDY_0097;
OS Shigella dysenteriae serotype 1 (strain Sd197).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=300267;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sd197;
RX PubMed=16275786; DOI=10.1093/nar/gki954;
RA Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA Jin Q.;
RT "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT bacillary dysentery.";
RL Nucleic Acids Res. 33:6445-6458(2005).
CC -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC stress conditions as well as yfdZ. Represses its own transcription
CC under both stress and non-stress conditions. Might act as a sensor of
CC the intracellular accumulation of phosphoglucose by binding these
CC molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC Rule:MF_01449}.
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DR EMBL; CP000034; ABB60333.1; -; Genomic_DNA.
DR RefSeq; WP_001138610.1; NC_007606.1.
DR RefSeq; YP_401822.1; NC_007606.1.
DR AlphaFoldDB; Q32K24; -.
DR SMR; Q32K24; -.
DR STRING; 300267.SDY_0097; -.
DR PRIDE; Q32K24; -.
DR EnsemblBacteria; ABB60333; ABB60333; SDY_0097.
DR KEGG; sdy:SDY_0097; -.
DR PATRIC; fig|300267.13.peg.115; -.
DR HOGENOM; CLU_017028_12_3_6; -.
DR OMA; WLTWQAE; -.
DR Proteomes; UP000002716; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01449; HTH_type_SgrR; 1.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR000914; SBP_5_dom.
DR InterPro; IPR025370; SgrR_HTH_N.
DR InterPro; IPR023767; Tscrpt_reg_SgrR.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR Pfam; PF12793; SgrR_N; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..552
FT /note="HTH-type transcriptional regulator SgrR"
FT /id="PRO_0000309252"
FT DOMAIN 1..116
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT DNA_BIND 26..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT REGION 163..492
FT /note="Solute-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ SEQUENCE 552 AA; 64107 MW; AF382C41654227AF CRC64;
MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
RGKRSRLIFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEA NGELEADIAH HWQQISPLHW
RFFLRPGVHF HHGRELEMDD VIASFKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP
LLLGQVPAMI LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG
IMQQILASHQ VTLEIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
FKSAWFAPPD PE
