ID   SGRR_SHIF8              Reviewed;         551 AA.
AC   Q0T8C8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=SFV_0061;
OS   Shigella flexneri serotype 5b (strain 8401).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=373384;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8401;
RX   PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA   Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J.,
RA   Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.;
RT   "Complete genome sequence of Shigella flexneri 5b and comparison with
RT   Shigella flexneri 2a.";
RL   BMC Genomics 7:173-173(2006).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions. Might act as a sensor of
CC       the intracellular accumulation of phosphoglucose by binding these
CC       molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01449}.
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DR   EMBL; CP000266; ABF02348.1; -; Genomic_DNA.
DR   RefSeq; WP_005053586.1; NC_008258.1.
DR   AlphaFoldDB; Q0T8C8; -.
DR   SMR; Q0T8C8; -.
DR   EnsemblBacteria; ABF02348; ABF02348; SFV_0061.
DR   KEGG; sfv:SFV_0061; -.
DR   HOGENOM; CLU_017028_12_3_6; -.
DR   OMA; WLTWQAE; -.
DR   BioCyc; SFLE373384:SFV_RS00350-MON; -.
DR   Proteomes; UP000000659; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..551
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000309254"
FT   DOMAIN          1..116
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   REGION          163..492
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ   SEQUENCE   551 AA;  63966 MW;  51AEDFDBB0A6B058 CRC64;
     MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR GWLTWEAEVG
     RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK ATVRQMLVSH LGRSFRQGRH
     ILRVLYYRPL RNLLPGSALR RSETHIARQI FSSLTRINEE NGELEADIAH HWQQISPLHW
     RFFLRPGVHF HHGRELEMDD VIASLKRINT LPLYSHITDI VSPTPWTLDI HLTQPDRWLP
     LLLGQVPAMI LPCEWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
     VWVLPEIADE PAGGLMLKGP QGEKKEIESR LEEGCYYLLF DSRTHRGANQ QVRDWVSYVL
     SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG LESLTLTFYQ DHSEHRVIAG
     IMQQILASHQ VTLEIKEISY DQWHEGEIES DIWLNSANFT LPLDFSLFAH LCEVPLLQHC
     IPIDWQADAA RWRNGEMNLA NWCQQLVASK AMVPLIHHWL IIQGQRSMRG LRMNTLGWFD
     FKSAWFAPPD P