ID   SGRR_YERE8              Reviewed;         553 AA.
AC   A1JJG7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=YE0644;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions. Might act as a sensor of
CC       the intracellular accumulation of phosphoglucose by binding these
CC       molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01449}.
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DR   EMBL; AM286415; CAL10755.1; -; Genomic_DNA.
DR   RefSeq; WP_011815554.1; NC_008800.1.
DR   RefSeq; YP_001004995.1; NC_008800.1.
DR   AlphaFoldDB; A1JJG7; -.
DR   SMR; A1JJG7; -.
DR   STRING; 393305.YE0644; -.
DR   EnsemblBacteria; CAL10755; CAL10755; YE0644.
DR   KEGG; yen:YE0644; -.
DR   PATRIC; fig|393305.7.peg.737; -.
DR   eggNOG; COG4533; Bacteria.
DR   HOGENOM; CLU_017028_12_3_6; -.
DR   OMA; WLTWQAE; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..553
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000309256"
FT   DOMAIN          1..117
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   REGION          163..494
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ   SEQUENCE   553 AA;  64932 MW;  21FBAD8EACA40B0B CRC64;
     MSTARLQQQF IRLWQRFSGL PTETTLQELA EVLCCSRRHV RSLLGSMQQE GWLSWQAEAG
     RGKRSQLTFL YSGLALQQQR AEELLEQEGI DQLVQLVGDK KAVRQMLLSQ LGRSFRQGKH
     ILRVLYYRPL QNLLPGTALR RSETHMVRQI FNGLTRINEE NGELEPDLSH HWQAISPLHW
     RFYLRPAIHF HHGRELEMND VITSLTRLIP QPLFSHITAV RSPTPYVIDV HLSAPDNWLP
     WLLGSVHAMI LPQEWENQPD FRRHPIGTGP YSVIRNHQSQ LKIQAFDNYF GFRALIDEVN
     IWVLPELSEE LVYSGVQLQA DDTSKNELES RLEEGCYFLL FDQRSPLTRN PDIRRWLCEL
     ITPVALLSHA DPFYQRYWSP AYGMLPRWHH NRLRVLETKP EGLTELTLTF YSHHSEFDAI
     SQTLTKLLAD QGVNLKIHVV DYTQWYQGDA QSDMWLGSAN FYLPLEFSLF ATLYELPLLQ
     YCLDEELHQD VELWRNNTLQ MADWSQRLVS QNQFHPLFHH WLELYGQHSM RGVRMNTLGW
     FDFKSAWFTP PET