SGRR_YERPE
ID SGRR_YERPE Reviewed; 553 AA.
AC Q74Q56; Q8CZP9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN OrderedLocusNames=YPO0524, y3650, YP_3655;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
CC -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC stress conditions as well as yfdZ. Represses its own transcription
CC under both stress and non-stress conditions. Might act as a sensor of
CC the intracellular accumulation of phosphoglucose by binding these
CC molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC Rule:MF_01449}.
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DR EMBL; AE017042; AAS63803.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM87198.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL19205.1; -; Genomic_DNA.
DR PIR; AC0065; AC0065.
DR RefSeq; WP_002210461.1; NZ_VWRZ01000012.1.
DR RefSeq; YP_002345598.1; NC_003143.1.
DR AlphaFoldDB; Q74Q56; -.
DR SMR; Q74Q56; -.
DR IntAct; Q74Q56; 2.
DR STRING; 214092.YPO0524; -.
DR PaxDb; Q74Q56; -.
DR DNASU; 1148597; -.
DR EnsemblBacteria; AAM87198; AAM87198; y3650.
DR EnsemblBacteria; AAS63803; AAS63803; YP_3655.
DR GeneID; 57974087; -.
DR KEGG; ype:YPO0524; -.
DR KEGG; ypk:y3650; -.
DR KEGG; ypm:YP_3655; -.
DR PATRIC; fig|214092.21.peg.776; -.
DR eggNOG; COG4533; Bacteria.
DR HOGENOM; CLU_017028_12_3_6; -.
DR OMA; WLTWQAE; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01449; HTH_type_SgrR; 1.
DR InterPro; IPR039424; SBP_5.
DR InterPro; IPR000914; SBP_5_dom.
DR InterPro; IPR025370; SgrR_HTH_N.
DR InterPro; IPR023767; Tscrpt_reg_SgrR.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30290; PTHR30290; 1.
DR Pfam; PF00496; SBP_bac_5; 1.
DR Pfam; PF12793; SgrR_N; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..553
FT /note="HTH-type transcriptional regulator SgrR"
FT /id="PRO_0000309257"
FT DOMAIN 1..113
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT DNA_BIND 26..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT REGION 163..494
FT /note="Solute-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT CONFLICT 415
FT /note="S -> T (in Ref. 2; AAM87198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 553 AA; 64849 MW; 9D1FED097126C444 CRC64;
MSTSRLQQQF IRLWQRYNGQ STETTLQALA EVLNCSRRHV RSLLGKMQHA GWLDWQAEAG
RGKRSQLIFL RSGLALQQQR AEELLEQDHI DQLVQLVGDK KAVRQMLLSQ LGRSFRQGKH
ILRVLYYRPL ENLLPGTALR RSETHMVRQI FNGLTRINEE NGELEPDLSH HWQAITPLHW
RFYLRPAIHF HHGRELEMSD VISSLTRLIP QPLFSHIAEV RSPTPYVIDV YLHSPDHWLP
WLLGSVHAMI LPQEWETQPD FHRQPIGTGP YSVIRNHHSQ LKIQAFDNYF GFRALIDEVN
IWVLPELSEE LVYSGVQLQA DDTGKNELES RLEEGCYFLL FDQRSPQACT PEIRRWLCEL
ITPIALLSHA APFYQRYWSP AYGMLPRWHH NRLTTQEPKP EGLNELTLTF YSEHSEFDAI
SQTLTQLLAA QGVTLKIQVL DYTRWYQGDA QSDIWLGSAN FYLPLEFSLF ATLYEMPLLQ
HCLSEELHQD IESWRNNTLL MADWSQRLVS QHQFHPLFHH WLELYGQHSM RGVRMNTLGW
FDFKSAWFTP PEA
