ID   SGRR_YERPS              Reviewed;         553 AA.
AC   Q66EM6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=HTH-type transcriptional regulator SgrR {ECO:0000255|HAMAP-Rule:MF_01449};
GN   Name=sgrR {ECO:0000255|HAMAP-Rule:MF_01449}; OrderedLocusNames=YPTB0667;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Activates the small RNA gene sgrS under glucose-phosphate
CC       stress conditions as well as yfdZ. Represses its own transcription
CC       under both stress and non-stress conditions. Might act as a sensor of
CC       the intracellular accumulation of phosphoglucose by binding these
CC       molecules in its C-terminal solute-binding domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01449}.
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DR   EMBL; BX936398; CAH19907.1; -; Genomic_DNA.
DR   RefSeq; WP_011191725.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q66EM6; -.
DR   SMR; Q66EM6; -.
DR   EnsemblBacteria; CAH19907; CAH19907; YPTB0667.
DR   GeneID; 66842913; -.
DR   KEGG; ypo:BZ17_1890; -.
DR   KEGG; yps:YPTB0667; -.
DR   PATRIC; fig|273123.14.peg.2008; -.
DR   OMA; WLTWQAE; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01449; HTH_type_SgrR; 1.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   InterPro; IPR025370; SgrR_HTH_N.
DR   InterPro; IPR023767; Tscrpt_reg_SgrR.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   Pfam; PF12793; SgrR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..553
FT                   /note="HTH-type transcriptional regulator SgrR"
FT                   /id="PRO_0000309261"
FT   DOMAIN          1..113
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   DNA_BIND        26..49
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
FT   REGION          163..494
FT                   /note="Solute-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01449"
SQ   SEQUENCE   553 AA;  64893 MW;  6F689F7C7123C799 CRC64;
     MSTSRLQQQF IRLWQRYNGQ STETTLQALA EVLNCSRRHV RSLLGKMQHA GWLDWQAEAG
     RGKRSQLIFL RSGLALQQQR AEELLEQDHI DQLVQLVGDK KAVRQMLLSQ LGRSFRQGKH
     ILRVLYYRPL ENLLPGTALR RSETHMVRQI FNGLTRINEE NGELEPDLSH HWQAITPLHW
     RFYLRPAIHF HHGRELEMSD VISSLTRLIP QPLFSHIAEV RSPTPYVIDV YLHSPDHWLP
     WLLGSVHAMI LPQEWETQPD FHRQPIGTGP YSVIRNHHSQ LKIQAFDNYF GFRALIDEVN
     IWVLPELSEE LVYSGVQLQA DDTGKNELES RLEEGCYFLL FDQRSPQACT PEIRRWLCEL
     ITPIALLSHA DPFYQRYWSP AYGMLPRWHH NRLTTQEPKP EGLNELTLTF YSEHSEFDAI
     SQTLTQLLAA QGVTLKIQVL DYTRWYQGDA QSDIWLGSAN FYLPLEFSLF ATLYEMPLLQ
     HCLSEELHQD IESWRNNTLL MADWSQRLVS QHQFHPLFHH WLELYGQHSM RGVRMNTLGW
     FDFKSAWFTP PEA