ID   SGRT_ECOLI              Reviewed;          43 AA.
AC   C1P5Z7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Putative inhibitor of glucose uptake transporter SgrT;
GN   Name=sgrT; OrderedLocusNames=b4662, JW0068.1;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   IDENTIFICATION, FUNCTION IN CONTROL OF GLUCOSE PHOSPHOTRANSFERASE SYSTEM,
RP   AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=18042713; DOI=10.1073/pnas.0708102104;
RA   Wadler C.S., Vanderpool C.K.;
RT   "A dual function for a bacterial small RNA: SgrS performs base pairing-
RT   dependent regulation and encodes a functional polypeptide.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:20454-20459(2007).
RN   [4]
RP   IDENTIFICATION, AND INDUCTION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=19121005; DOI=10.1111/j.1365-2958.2008.06495.x;
RA   Hemm M.R., Paul B.J., Schneider T.D., Storz G., Rudd K.E.;
RT   "Small membrane proteins found by comparative genomics and ribosome binding
RT   site models.";
RL   Mol. Microbiol. 70:1487-1501(2008).
CC   -!- FUNCTION: Acts to promote recovery from glucose-phosphate stress due to
CC       intracellular accumulation of glucose-6-phosphate caused by disruption
CC       of glycolytic flux or in the presence of (toxic) non-metabolizable
CC       glucose phosphate analogs. It may do so by inhibiting the transporter
CC       activity for glucose uptake (PtsG) as cells that overexpress this
CC       protein do not seem to import glucose although they have nearly wild-
CC       type levels of PtsG. {ECO:0000269|PubMed:18042713}.
CC   -!- INDUCTION: By (toxic) non-metabolizable glucose phosphate analogs under
CC       the control of SgrR (at protein level). {ECO:0000269|PubMed:18042713,
CC       ECO:0000269|PubMed:19121005}.
CC   -!- MISCELLANEOUS: Entirely encoded within the transcript for the small RNA
CC       sgrS.
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DR   EMBL; U00096; ACO59989.1; -; Genomic_DNA.
DR   EMBL; AP009048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_001248770.1; NZ_STEB01000010.1.
DR   RefSeq; YP_002791237.1; NC_000913.3.
DR   AlphaFoldDB; C1P5Z7; -.
DR   SMR; C1P5Z7; -.
DR   STRING; 511145.b4662; -.
DR   TCDB; 4.A.1.1.1; the pts glucose-glucoside (glc) family.
DR   PaxDb; C1P5Z7; -.
DR   PRIDE; C1P5Z7; -.
DR   EnsemblBacteria; ACO59989; ACO59989; b4662.
DR   GeneID; 66671641; -.
DR   GeneID; 7751624; -.
DR   KEGG; eco:b4662; -.
DR   PATRIC; fig|1411691.4.peg.2212; -.
DR   eggNOG; ENOG5031KWV; Bacteria.
DR   BioCyc; EcoCyc:MON0-2842; -.
DR   PRO; PR:C1P5Z7; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0004857; F:enzyme inhibitor activity; IMP:EcoCyc.
DR   GO; GO:0046325; P:negative regulation of glucose import; IMP:EcoCyc.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Phosphotransferase system; Reference proteome; Sugar transport; Transport.
FT   CHAIN           1..43
FT                   /note="Putative inhibitor of glucose uptake transporter
FT                   SgrT"
FT                   /id="PRO_0000381978"
SQ   SEQUENCE   43 AA;  5338 MW;  61DE61D3634A4496 CRC64;
     MRQFYQHYFT ATAKLCWLRW LSVPQRLTML EGLMQWDDRN SES