ID   SGS3_SOLLC              Reviewed;         633 AA.
AC   A5YVF1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Protein SUPPRESSOR OF GENE SILENCING 3;
DE   AltName: Full=SlSGS3;
GN   Name=SGS3;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH
RP   TOMATO YELLOW LEAF CURL VIRUS V2.
RX   PubMed=18165314; DOI=10.1073/pnas.0709036105;
RA   Glick E., Zrachya A., Levy Y., Mett A., Gidoni D., Belausov E.,
RA   Citovsky V., Gafni Y.;
RT   "Interaction with host SGS3 is required for suppression of RNA silencing by
RT   tomato yellow leaf curl virus V2 protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:157-161(2008).
CC   -!- FUNCTION: Required for post-transcriptional gene silencing and natural
CC       virus resistance.
CC   -!- SUBUNIT: Interacts with begomoviruses protein V2.
CC       {ECO:0000269|PubMed:18165314}.
CC   -!- INTERACTION:
CC       A5YVF1; Q764F6: V2; Xeno; NbExp=3; IntAct=EBI-15678015, EBI-15678004;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:18165314}. Note=Accumulates in inclusion bodies in
CC       the cell periphery. May interact with the ER network from the
CC       perinuclear region out to the cell periphery (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Does not move between plant cells.
CC   -!- SIMILARITY: Belongs to the SGS3 family. {ECO:0000305}.
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DR   EMBL; EF590136; ABQ96272.1; -; mRNA.
DR   RefSeq; NP_001234711.1; NM_001247782.1.
DR   AlphaFoldDB; A5YVF1; -.
DR   SMR; A5YVF1; -.
DR   DIP; DIP-29657N; -.
DR   IntAct; A5YVF1; 1.
DR   STRING; 4081.Solyc04g025300.2.1; -.
DR   PaxDb; A5YVF1; -.
DR   PRIDE; A5YVF1; -.
DR   GeneID; 100134882; -.
DR   KEGG; sly:100134882; -.
DR   eggNOG; ENOG502QPU5; Eukaryota.
DR   InParanoid; A5YVF1; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; A5YVF1; baseline.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051607; P:defense response to virus; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd12266; RRM_like_XS; 1.
DR   Gene3D; 3.30.70.2890; -; 1.
DR   InterPro; IPR044287; SGS3.
DR   InterPro; IPR005380; XS_domain.
DR   InterPro; IPR038588; XS_domain_sf.
DR   InterPro; IPR005381; Znf-XS_domain.
DR   PANTHER; PTHR46602; PTHR46602; 1.
DR   Pfam; PF03468; XS; 1.
DR   Pfam; PF03470; zf-XS; 1.
PE   1: Evidence at protein level;
KW   Antiviral protein; Coiled coil; Cytoplasm; Reference proteome;
KW   RNA-mediated gene silencing.
FT   CHAIN           1..633
FT                   /note="Protein SUPPRESSOR OF GENE SILENCING 3"
FT                   /id="PRO_0000333290"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          565..606
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..191
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  72529 MW;  B2D066B9CBEA80F4 CRC64;
     MSFSKWGGKP SNSSEKQKAS STPTVEEINR GVGDIGLNSE QNEGWEVYAR KPKNKGGSSA
     GKQWAPQNPS PKAWGNQNTK AWGHPDVGKK SGTRNNAGSG RGSGNNWSTP SDPQKLARPH
     LYDGGFPSSA PVPPALKNGW DWSSRVASAH PKDNSQVAAA ADDDKASEHD AEDNELDFLD
     ESDDDLHSDD FDSDVGEMSY ETRKKNPWFN QLFHSLDSLT VTEINEPERQ WHCPACKGGP
     GAIEWFTGLQ SLMTHAKTKG LRVKIHRELA ELLEEDLRQR GTSVVPPGEV YGRWGGMEFK
     DKEIVWPPMV IIMNTRLDKD ENDKWIGMGN QELLEYFSSY AAVKARHSYG PQGHRGMSLL
     IFEASAVGYI EADRLSEHFS ENGRNRDAWE RRSARFYPGG KRLLYGYMAD KKDIDNFNQH
     SAGKSKLKFE MRSYKEAVWN PAKQMREDNQ QLIWFKNKAA KHQMQAKALE ESLSLVSEKH
     RQTLEENKIV RLKTKMHHEQ IKEEMEFQEQ FFKDQIKIIH DARTAREDNF EKTQQEQREM
     VKQSNANTAS VEDHRVRAEK VAKFIKLQDK EMEEFVEERE NLMRTHDDRI AALRRKYWEE
     EVELERKFDL ELSKLMEKYS PKQSDEVNSS GTM