ID   SGSM3_BOVIN             Reviewed;         747 AA.
AC   Q2KI13;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Small G protein signaling modulator 3;
DE   AltName: Full=RUN and TBC1 domain-containing protein 3;
GN   Name=SGSM3 {ECO:0000250|UniProtKB:Q96HU1};
GN   Synonyms=RUTBC3 {ECO:0000312|EMBL:AAI12809.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI12809.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI12809.1};
RC   TISSUE=Hypothalamus {ECO:0000312|EMBL:AAI12809.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a cooperative role in NF2-mediated growth
CC       suppression of cells. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GJA1. Interaction with GJA1 induces its
CC       degradation. Interacts via its RUN domain with the C-terminal region of
CC       NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B,
CC       RAP2A, RAP2B and PDCD6I. No interaction with RAB27A (By similarity).
CC       {ECO:0000250|UniProtKB:Q8VCZ6, ECO:0000250|UniProtKB:Q96HU1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96HU1}.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000305}.
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DR   EMBL; BC112808; AAI12809.1; -; mRNA.
DR   RefSeq; NP_001070013.1; NM_001076545.1.
DR   AlphaFoldDB; Q2KI13; -.
DR   BMRB; Q2KI13; -.
DR   SMR; Q2KI13; -.
DR   STRING; 9913.ENSBTAP00000012674; -.
DR   PaxDb; Q2KI13; -.
DR   PRIDE; Q2KI13; -.
DR   Ensembl; ENSBTAT00000012674; ENSBTAP00000012674; ENSBTAG00000009624.
DR   GeneID; 767820; -.
DR   KEGG; bta:767820; -.
DR   CTD; 27352; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009624; -.
DR   VGNC; VGNC:34552; SGSM3.
DR   eggNOG; KOG2222; Eukaryota.
DR   GeneTree; ENSGT00940000157282; -.
DR   HOGENOM; CLU_020721_0_0_1; -.
DR   InParanoid; Q2KI13; -.
DR   OMA; NSPGWVQ; -.
DR   OrthoDB; 1162786at2759; -.
DR   TreeFam; TF317336; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000009624; Expressed in choroid plexus and 105 other tissues.
DR   ExpressionAtlas; Q2KI13; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005921; C:gap junction; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR   GO; GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0032483; P:regulation of Rab protein signal transduction; ISS:UniProtKB.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; SSF140741; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; Cytoplasm; Growth arrest; Phosphoprotein;
KW   Reference proteome; SH3 domain.
FT   CHAIN           1..747
FT                   /note="Small G protein signaling modulator 3"
FT                   /id="PRO_0000307809"
FT   DOMAIN          111..302
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   DOMAIN          477..536
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          552..715
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT   COILED          412..435
FT                   /evidence="ECO:0000255"
FT   MOD_RES         403
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VCZ6"
SQ   SEQUENCE   747 AA;  85010 MW;  8469702DD0198892 CRC64;
     MSGSHVPSAN GPFSALTPSM WPQEILAKYA QEEATVEQPE FRYDEFGFRV DKEDADGIPY
     SGQLLEDPPQ RLRWQAHLEF THNHDVGDLT WDKIAVSLPR SEKLRSLVLA GVPHSMRPQL
     WMRLSGALQK KRNSELSYRE IVKNSSNDET IAAKQIEKDL LRTMPSNACF AHVSGVGVPR
     LRRVLRALAW LYPEIGYCQG TGMVAACLLL FLEEDDAFWM MCAIIEDLLP ASYFSTTLLG
     VQTDQRVLRH LIVQYLPRLD RLLQEHDIEL SLITLHWFLT AFASVVHIRL LLRLWDLFFY
     EGSLVLFQAT LGMLRLKEDE LIQSENSASI FNTLSDIPSQ LEDADLLLAE AMRLAGSLTA
     VAVETQRRKH LAYLLADQGQ LLGAPATTGL SQVVRRRTQR RKSGITSLLF GEDDLEAMKA
     KNIKQTELVA DLREAILRVA RHFQCTDPKN CNVELTPDYS MESHQRDHES YVACSRGHPR
     RAKALLDFER HDDDELGFRK NDIITIVSQK DEHCWVGELN GLRGWFPAKF VEVLDERSKE
     YSIAGDDAVT EGVTDLVRGT LCPALKALLE HGLKKPSLLG GACHPWLFIE EAAGREVERD
     FDSVYSRLVL CKTYRLDEDG KVLTPEELLY RAVQSVNVTH DAAHAQMDVK LRSLICVGLN
     EQVLHLWLEV LCSSLPTVEK WYQPWSFLRS PGWVQIKCEL RVLCCFAFSL SQDWELPAKR
     EEEKKPLKEG VQDMLVKHHL FSWDIDG