ID   SGSM3_DANRE             Reviewed;         755 AA.
AC   Q7T2D0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Small G protein signaling modulator 3;
DE   AltName: Full=RUN and TBC1 domain-containing protein 3;
GN   Name=sgsm3 {ECO:0000250|UniProtKB:Q96HU1};
GN   Synonyms=rutbc3 {ECO:0000312|ZFIN:ZDB-GENE-040426-2635};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH54597.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH54597.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000305}.
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DR   EMBL; BC054597; AAH54597.1; -; mRNA.
DR   RefSeq; NP_998495.1; NM_213330.1.
DR   AlphaFoldDB; Q7T2D0; -.
DR   BMRB; Q7T2D0; -.
DR   SMR; Q7T2D0; -.
DR   STRING; 7955.ENSDARP00000017428; -.
DR   PaxDb; Q7T2D0; -.
DR   Ensembl; ENSDART00000020342; ENSDARP00000017428; ENSDARG00000019038.
DR   GeneID; 406635; -.
DR   KEGG; dre:406635; -.
DR   CTD; 27352; -.
DR   ZFIN; ZDB-GENE-040426-2635; sgsm3.
DR   eggNOG; KOG2222; Eukaryota.
DR   GeneTree; ENSGT00940000157282; -.
DR   HOGENOM; CLU_020721_0_0_1; -.
DR   InParanoid; Q7T2D0; -.
DR   OMA; NSPGWVQ; -.
DR   OrthoDB; 1162786at2759; -.
DR   PhylomeDB; Q7T2D0; -.
DR   TreeFam; TF317336; -.
DR   PRO; PR:Q7T2D0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000019038; Expressed in brain and 42 other tissues.
DR   ExpressionAtlas; Q7T2D0; baseline.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; SSF140741; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; SH3 domain.
FT   CHAIN           1..755
FT                   /note="Small G protein signaling modulator 3"
FT                   /id="PRO_0000307813"
FT   DOMAIN          115..306
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   DOMAIN          484..543
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          559..722
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT   COILED          419..445
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   755 AA;  86319 MW;  2977ECADD350C988 CRC64;
     MSGSYTPAPG GPFSALTPSM WPQDILAKYC QKDPGTEVEL QYDEFGFRID SEDGVETRKW
     LCGDGAPQRE DPQQRLRWQA HLEFTHNHTV GDLTWDKITP TLARSDRLRS LVLGGIPHSM
     RPQLWMRLSG ALQKKRTSDI SYREIVKNSS NDDTTAAKQI EKDLLRTMPT NACFNTLTSV
     GVPKLRRVLR GLAWLYPDIG YCQGTGMVVS CLLLFLEEED ALWMMCALIE DLLPPSYFSS
     TLLGVQTDQR VLRQLIVQYL PRLDKLLQEH DIELSLITLH WFLTAFASVV DIRILLRIWD
     LLFYEGSMVL FQVTLGMLKI KEDELVSSEN SASIFNTLSD LPSQLEDGAA VLGEAVRLAG
     SLSQENLDTH RHKHLAYILA EQAQLNSNNS HSLNTNLNKV VRRQNMRRKS TLSSLLWGED
     EVEALKAKNI KQTELVAALR EAINRTAEHF HCLDPRNCST DLTPDYSMES HQRDHENFLV
     VSRNRRRRAK ALLDFERHDD DELGFRKNDI ITIISQKDEH CWVGELNGLR GWFPAKFVEI
     LDERSKEYSL AGDDTVTEAV NDLVRGSLCP ALKAIFQHGL KKPSILGGPC HPWLFIEEAA
     SKEVERDFNS VYSRLVLCKT YRLDEDGKVL TPEELLYRAV QSVNMSHDTA HVQMDVKFRS
     LICVGLNEQV LHLWLEVLCS SMSAVEKWYH PWSFLRSPGW VQIKCELRVL SKFAFSLSQD
     CELPTKKEEK EQRPLKEGVQ DMLVKHHLFS WDIDG