ID   SGSM3_XENLA             Reviewed;         753 AA.
AC   A6H8I2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Small G protein signaling modulator 3 homolog;
DE   AltName: Full=RUN and TBC1 domain-containing protein 3;
GN   Name=sgsm3; Synonyms=rutbc3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI46621.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI46621.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000305}.
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DR   EMBL; BC146620; AAI46621.1; -; mRNA.
DR   RefSeq; NP_001093372.1; NM_001099902.1.
DR   AlphaFoldDB; A6H8I2; -.
DR   SMR; A6H8I2; -.
DR   GeneID; 100101321; -.
DR   KEGG; xla:100101321; -.
DR   CTD; 100101321; -.
DR   Xenbase; XB-GENE-965525; sgsm3.S.
DR   OrthoDB; 1162786at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 100101321; Expressed in pancreas and 19 other tissues.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; SSF140741; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; SH3 domain.
FT   CHAIN           1..753
FT                   /note="Small G protein signaling modulator 3 homolog"
FT                   /id="PRO_0000307814"
FT   DOMAIN          115..306
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   DOMAIN          482..541
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          557..720
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
SQ   SEQUENCE   753 AA;  86212 MW;  3FA6D38B2B99DBCA CRC64;
     MSGSYTPSPG GPFSALTASM WPQDILAKYT QKEQTVEQPE FRYDEFGFRV DKEDGAEPNS
     SKLLGIPLTE DPQQRLRWQA HLEFTHNHDV GDLTWDKIDV TLPHSDKLRS LVLAGIPHSM
     RPQLWMRLSG ALQKKQNSEM TYKDIGRNSS NDDTLAAKQI EKDLLRTMPS NACFSNLQSV
     GVPRLRRVLR GLAWLFPDIG YCQGTGMVAA CLLLFLEEED AFWMMATIVE DLVPVSYFNT
     TLVGVQTDQR VLRHLIVQYL PRLDKLLQEH DIELSLITLH WFLTAFASVV HIKLLLRIWD
     FFFYQGSLVL FQTTLGMLKM KEEELIQSEN SASIFNTLSD IPSQIEEADV LLREAMLISG
     TLTEVMIEAQ RRKHLAYLIA DQGQLLNSTA AVANLSKIMR RQSQRRKSAI TTLLFGDDNF
     EALKSKNIKQ TALVADLREA ILQVARHFQY TDPKNCSIDL TPDYTMESHQ RDHENYVSCS
     QSRRRRAKAL LDFERHDDDE LGFRKNDIIT IISQKDEHCW VGELNGLRGW FPAKFVDILD
     ERSKEYSVAG DDSVTEGITD LIRGTLSPSI KSIFEHGLKK PSLLGGPCHP WLFIEEAASR
     EVERDFDSVY SRLVLCKTYR LDEDGKVLTP EELLYRGVQS VNVSHDAAHA QMDVKLRSLI
     SIGLNEQVLH LWLEVLCSSL PTVEKWYQPW SFLRSPGWVQ IKCELRVLSK FAFSLSPDWE
     LPVKREDKEK KPLKEGVQDM LVKHHLFSWD IDG