ID   SGT1_DICDI              Reviewed;         387 AA.
AC   Q55ED0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Protein SGT1 homolog {ECO:0000250|UniProtKB:Q08446};
DE   AltName: Full=Suppressor of G2 allele of SKP1 homolog {ECO:0000250|UniProtKB:Q08446};
GN   Name=sugt1 {ECO:0000312|dictyBase:DDB_G0269292}; ORFNames=DDB_G0269292;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play a role in ubiquitination and subsequent proteasomal
CC       degradation of target proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SGT1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL71996.1; -; Genomic_DNA.
DR   RefSeq; XP_645851.1; XM_640759.1.
DR   AlphaFoldDB; Q55ED0; -.
DR   SMR; Q55ED0; -.
DR   STRING; 44689.DDB0267067; -.
DR   PaxDb; Q55ED0; -.
DR   EnsemblProtists; EAL71996; EAL71996; DDB_G0269292.
DR   GeneID; 8616795; -.
DR   KEGG; ddi:DDB_G0269292; -.
DR   dictyBase; DDB_G0269292; sugt1.
DR   eggNOG; KOG0548; Eukaryota.
DR   eggNOG; KOG1309; Eukaryota.
DR   HOGENOM; CLU_039532_1_0_1; -.
DR   InParanoid; Q55ED0; -.
DR   OMA; WDKLVGD; -.
DR   PhylomeDB; Q55ED0; -.
DR   Reactome; R-DDI-844456; The NLRP3 inflammasome.
DR   PRO; PR:Q55ED0; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISS:dictyBase.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR007699; SGS_dom.
DR   InterPro; IPR044563; Sgt1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45862; PTHR45862; 1.
DR   Pfam; PF04969; CS; 1.
DR   Pfam; PF05002; SGS; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS51048; SGS; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway.
FT   CHAIN           1..387
FT                   /note="Protein SGT1 homolog"
FT                   /id="PRO_0000330903"
FT   REPEAT          1..34
FT                   /note="TPR 1"
FT   REPEAT          36..67
FT                   /note="TPR 2"
FT   REPEAT          68..101
FT                   /note="TPR 3"
FT   DOMAIN          193..282
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   DOMAIN          301..387
FT                   /note="SGS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00386"
FT   REGION          110..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          299..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..144
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  43405 MW;  FE7B2486631A88BC CRC64;
     MEQLKEGNSY FVDEQYDEAL KCYDKACLEL SNNAEAFFKR SQCHSKLSNL KEALSDINTS
     IKLDSNNSKY YLKKGQLCFE LEEFDTALKT FEKGQSIDSE NSSFKTWIRK SKAEIQSNPT
     TTTTTTPTPT PTPTPAPQPV TTTTNPTPIP TTSNTTTTTN NNNNNNNNNN NNNNNNNTTT
     DSTTTKLPIP SSGNKVRHEW YQTETHVVLT IFAKFVTASN SKINLTSKSV NISFPLANGS
     EFLFEMDLFD PIVDKDSTIH YYSTKVEIKM KKSRAIKWDT LEFTDKSGPV GLMDQISSSP
     AVPSPYASKK DWDKLPNEPE EKLEGDQALN KIFRDIFSKG SEDQQRAMMK SFTESGGTVL
     STNWDEVGSK KVVGEPPKGL EFKQYEK